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Journal of Cellular Immunology
ISSN: 2689-2812
Structural Consequences of Variation in SARS-CoV-2 B.1.1.7
New globally circulating SARS-CoV-2 strains are causing concern about evolution of virus transmissibility, fitness and immune evasion mechanisms. A variant emerging from the United Kingdom called SARS-CoV-2 VUI 202012/01, or B.1.1.7, is thought to exhibit increased transmissibility that results from replication 4-10 times faster than the original Wuhan virus (Wuhan-Hu-1).
J Cell Immunol, 2021, Volume 3, Issue 2, p103-108 | DOI: 10.33696/immunology.3.085M1 Macrophages are More Susceptible to Necroptosis
Macrophages are important cells of the innate immune system and play a crucial role in host immune defense against infection and injury [1-3]. Macrophages form the first line of defense against airborne particles and microbes through multiple functions including phagocytosis, production of cytokines and chemokines, and antigen presentation.
J Cell Immunol, 2021, Volume 3, Issue 2, p97-102 | DOI: 10.33696/immunology.3.084Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development
Calcium (Ca2+) is an intracellular universal second messenger that regulates a variety of cellular processes. Many biological processes, including gene transcription, cell cycle, migration, and apoptosis, are affected by changes in intracellular Ca2+ signaling. Disruption of normal Ca2+ signaling can cause tumorigenic phenotypes.
J Cell Immunol, 2021, Volume 3, Issue 3, p144-150 | DOI: 10.33696/immunology.3.091Review of the COVID-19 Risk in Multiple Sclerosis
Severe respiratory syndrome coronavirus-2 (SARSCoV- 2) is the virus responsible for the novel coronavirus disease of 2019 (COVID-19) and has resulted in the death of over one million people around the world. COVID- 19’s presentation is highly heterogeneous as cases range from asymptomatic to rapidly progressive resulting in low survival rates.
J Cell Immunol, 2021, Volume 3, Issue 2 | DOI: 10.33696/immunology.3.080Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense
Caspases are critical for regulating cell death, immune responses, and homeostasis. These cysteine-dependent endoproteases cleave their substrates after certain aspartic acid residues.
J Cell Immunol, 2020, Volume 2, Issue 6, p341-347 | DOI: https://doi.org/10.33696/immunology.2.064Current Advances in CAR T Cell Therapy for Malignant Mesothelioma
Malignant mesothelioma (MM) is an incurable primary tumor of the body’s serosal surfaces: the pleura, peritoneum, pericardium and the tunica vaginalis (in men).
J Cell Immunol, 2020, Volume 2, Issue 4, p192-200 | DOI: 10.33696/immunology.2.042Targeting the PI3K/AKT/mTOR/NFkB Axis in Ovarian Cancer
Phosphoinositol 3 kinase (PI3K) defines a class of lipid kinases that have the ability to phosphorylate the inositol ring 3?-OH group in inositol phospholipids and therefore produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3) [1]. PI3K encompasses a family of enzymes divided into: Class IA PI3K which includes three isomers (?, ?, ?) and Class IB which include the group (?).
J Cell Immunol, 2020, Volume 2, Issue 2, p68-73 | DOI: 10.33696/immunology.1.022CAR-T cell Goes on a Mathematical Model
Hundreds of new clinical trials were recently launched using chimeric antigen receptor-bearing T cells (CAR-T cell). Concentrated on hematological malignancies, with a 90% overall survival rate for 2 months on acute lymphoid leukemia (ALL-B) in young patients after two or more lines of therapy [1]. The most surprising results were the long-lasting effect of this therapy, resulting in more than 50% overall survival after a year follow-up.
J Cell Immunol, 2020, Volume 2, Issue 1, p31-37 | DOI: 10.33696/immunology.2.016TNFAIP8: Inflammation, Immunity and Human Diseases
Inflammation can be caused by various environmental factors, including microbial infection and toxic chemical exposure. In response to inflammation, immune cells like macrophages, B and T lymphocytes, fibroblasts, endothelial cells, and various stromal cells secrete soluble polypeptide cytokine Tumor Necrosis Factor Alpha (TNF?)
J Cell Immunol, 2019, Volume 1, Issue 2, p29-34 | DOI: 10.33696/immunology.1.007Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.