The aim of this study is to use the Python language to design an application program for grain properties, then use a database for computer applications to predict the physical, mechanical, and aerodynamic characteristics of some grains.

Syphilis is a bacterial disease potentially affecting all organs of the body. The symptoms may appear acutely or chronically over periods of many years, and - if left untreated – the disease may lead to premature death. The transmission of the spirochete (Treponema pallidum) occurs via skin and mucous contacts as well as via blood from mother to fetus. Congenital syphilis is associated with neonatal death or chronic morbidities of the skin, skeleton, brain and many other organs. 

In children, the global burden of vaccines-preventable diseases (VPDs) and deaths can be averted by adopting timely immunization practices. Administering immunization to a child within 28 or 30 days of the designated immunization date is referred to as timely immunization. Besides timely immunization, immunization non-compliance (invalid or delayed or missed immunization) increases the risk of various forms of VPDs and death in children, particularly living in urban slums. 

Introduction: Majocchi granuloma (MG) is a rare infection, generally caused by the dermatophyte Trichophyton rubrum. This disease results from the proliferation of the fungus along the hair follicle into the dermal or subcutaneous tissue, causing suppurative folliculitis. Most affected patients are immunocompromised, but it is not restricted to them. Its evolution is due to prolonged use of topical steroids.

The aim of this study is to use the Python language to design an application program for grain properties, then use a database for computer applications to predict the physical, mechanical, and aerodynamic characteristics of some grains.

In children, the global burden of vaccines-preventable diseases (VPDs) and deaths can be averted by adopting timely immunization practices. Administering immunization to a child within 28 or 30 days of the designated immunization date is referred to as timely immunization. Besides timely immunization, immunization non-compliance (invalid or delayed or missed immunization) increases the risk of various forms of VPDs and death in children, particularly living in urban slums. 

Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide. Effective prevention and management strategies are essential to reduce the burden of CVDs. This review summarizes recent advances in the prevention and management of CVDs. In terms of prevention, lifestyle modifications, such as diet, exercise, and smoking cessation, remain important strategies.

Liver fibrosis resulting from chronic liver injury can progress to cirrhosis and liver failure. Current treatments are limited, creating an urgent need for novel antifibrotic therapies. Multiple emerging approaches have shown preclinical promise in inhibiting liver fibrogenesis or stimulating regeneration, including artificial liver support, stem cell therapy, cell/gene therapy, nanomedicines, immunotherapy, and herbal medicines.

The aim of this study is to use the Python language to design an application program for grain properties, then use a database for computer applications to predict the physical, mechanical, and aerodynamic characteristics of some grains.

Introduction: End-stage chronic kidney disease (CKD) poses a significant challenge to patients' mental health, frequently leading to anxiety, depression, and sleep disturbances. This study aimed to identify factors associated with psychiatric vulnerability among patients with end-stage renal disease at the Zou/Collines Departmental Hospital in Benin. Methods: We conducted a cross-sectional study from January to June 2024, including patients with end-stage renal disease managed in the internal medicine department.

Background: Cutaneous T cell lymphoma (CTCL) is an incurable cancer characterized by elevated p38β and p38γ and downregulated tumor-suppressive p38α. Objectives: We aimed to identify selective p38β inhibitors and investigate their mechanisms and therapeutic implications in hematologic malignancies. Methods: A high-throughput screen of Food and Drug Administration (FDA)-approved compounds was conducted to identify p38β inhibitors. In vitro kinase assays, Western blots, scRNA-seq, synergy tests, and mass spectrometry were used. Clinical trial and public datasets were analyzed.

Lymphangioleiomyomatosis (LAM) is a rare, female-dominated pulmonary cystic disease. Cysts that develop in LAM are characterized by the presence of smooth muscle-like (LAMCore) cells in the periphery. These cells harbor mutations in Tuberous Sclerosis Complex 1 or 2 (TSC1/2), driving uncontrolled proliferation through the mTORC1 pathway. LAMCore cells originate from an extrapulmonary source. Published data supports the uterine origin of LAMCore cells that metastasize from the uterus to precipitate pulmonary function destruction. Immune evasion is hypothesized to occur to allow seeding of the lungs from the uterus. This evasion specifically involves dysfunctional NK cells to allow aberrant proliferation and migration from the tissue.