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2022

Volume 4, Issue 6, p194-224

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

The Importance of C5aR2 in Neutrophil Function and Its Impact on Neutrophil-mediated Diseases

C5aR2 serves as the second receptor for the anaphylatoxin C5a. It was identified about 10 years after identification of the first cognate receptor, C5aR1. Initially, C5aR2 was considered a mere decoy receptor for C5a. According to this view, its function was to scavenge excess C5a from C5aR1 and thereby exert anti-inflammatory effects. However, this initial view of C5aR2 had been oversimplified. 

J Cell Immunol, 2022, Volume 4, Issue 6, p194-201 | DOI: 10.33696/immunology.4.150

Ubiquitin-Dependent Regulation of Treg Function and Plasticity

Delicately, our immune system eliminates exogenous and endogenous threats and prevents harmful immune responses against the host. Regulatory T cells (Tregs) are indispensable in controlling immune responses and inducing immune tolerance; thus, immune homeostasis is maintained [1]. As a subset of CD4+ T cells, Tregs have been extensively studied for decades. They are best known for their ability to suppress immune responses, induce self-tolerance and help tumor cells escape immune surveillance [2-5]. Tregs mediate immune suppression via several mechanisms: They constitutively express cytotoxic T lymphocyte antigen-4 (CTLA-4), which competes with the costimulatory molecule CD28 for binding CD80/86 to downregulate T cell activation [6].

J Cell Immunol, 2022, Volume 4, Issue 6, p202-210 | DOI: 10.33696/immunology.4.151

Preliminary Evidence of Differentially Induced Immune Responses by Microparticle-adsorbed LPS in Patients with Crohn’s Disease

Inorganic microparticles are ubiquitous in the modern Western diet present as food additives and are actively scavenged by microfold (M) cells overlying human intestinal lymphoid aggregates. In Crohn’s disease (CD), inflammation is caused by the inability of the intestinal mucosa to sustain tolerance to gut luminal factors including bacteria and their by-products.

J Cell Immunol, 2022, Volume 4, Issue 6, p211-218 | DOI: 10.33696/immunology.4.152

Vγ2+ γδ T Cells and Their Regulatory Potential in Skin Allograft Survival

Our recently published research article “Vγ2+ γδ T cells in the presence of anti-CD40L control surgical inflammation and promote skin allograft survival” revealed that the Vγ2+ subset of γδ T cells, which otherwise are known primarily for its proinflammatory function, regulate the survival of skin allografts in the presence of anti-CD40L.

J Cell Immunol, 2022, Volume 4, Issue 6, p219-222 | DOI: 10.33696/immunology.4.153

Is Omicron Variant of COVID-19 Threatening Health Like Other Variants?

World health organization (WHO) designated the variant B.1.1.529 a variant of concern, named Omicron, as a fastspreading SARS-CoV-2 variant, on 26 November 2021 which started from Southern Africa. In addition to the new mutations (more than 30 mutations in the spike protein), Omicron also carries mutations similar to the alpha, beta, gamma, and delta variants of coronavirus, and is collectively known as the fifth most disturbing variant.

J Cell Immunol, 2022, Volume 4, Issue 6, p223-224 | DOI: 10.33696/immunology.4.154

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