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Journal of Cellular Immunology

ISSN: 2689-2812

Review Article Open Access
Volume 3 | Issue 3 | DOI: https://doi.org/10.33696/immunology.3.091

Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development

Changhao Cui2, Chen Wang1, Min Cao1, Xunlei Kang1,*
  • 1Center for Precision Medicine, Department of Medicine, University of Missouri, 1 Hospital Drive, Columbia, Missouri 65212,USA
  • 2School of Life Science and Medicine, Dalian University of Technology, Liaoning 124221, China
+ Affiliations - Affiliations

Corresponding Author

Xunlei Kang, kangxu@health.missouri.edu

Received Date: March 18, 2021

Accepted Date: April 20, 2021

Citation:

Cui C, Wang C, Cao M, Kang X. Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development. J Cell Immunol. 2021; 3(3): 144-150.


Copyright: © 2021 Cui C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ca2+/ calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca2+/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study.

Keywords

CaMKII, CaMKI, CaMKIV, Leukemia, ITIM containing receptor, Signaling pathway, Therapeutic target

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