Review Article Open Access
Volume 3 | Issue 3 | DOI: https://doi.org/10.33696/immunology.3.091

Ca2+/calmodulin-dependent Protein Kinases in Leukemia Development

  • 1Center for Precision Medicine, Department of Medicine, University of Missouri, 1 Hospital Drive, Columbia, Missouri 65212,USA
  • 2School of Life Science and Medicine, Dalian University of Technology, Liaoning 124221, China
+ Affiliations - Affiliations

Corresponding Author

Xunlei Kang, kangxu@health.missouri.edu

Received Date: March 18, 2021

Accepted Date: April 20, 2021


Ca2+/ calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca2+/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study.


CaMKII, CaMKI, CaMKIV, Leukemia, ITIM containing receptor, Signaling pathway, Therapeutic target

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