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Journal of Experimental Neurology
ISSN: 2692-2819
Hooshang Lahooti
University of Sydney, Australia
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Journal of Experimental Neurology is an international publication primarily dedicated to publish original research and novel findings in the neuroscience field. This journal offers a great opportunity to the neuroscientists to discuss and exchange their ideas and major advances in clinical and experimental neurology. The journal publishes original articles, reviews, editorials, letters, and short communications in all major concepts of experimental neurology.
Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review
Brain-computer interfaces (BCIs) are a rapidly advancing field which utilizes brain activity to control external devices for a myriad of functions, including the restoration of motor function. Clinically, BCIs have been especially impactful in patients who suffer from stroke-mediated damage. However, due to the rapid advancement in the field, there is a lack of accepted standards of practice.
Responsive Neurostimulation for Management of Refractory Precuneus Onset Epilepsy: A Case Report
Posterior quadrant epilepsy is relatively uncommon and refractory seizures from these regions are difficult to diagnose and manage. A 28-year-old woman presented for evaluation of her seizures. Scalp Electroencephalogram (EEG) showed seizures with independent onset over the right posterior and left anterior regions.
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Comparing Contrast Agent Enhancement: The Value of Artificial Intelligence/Machine Learning
Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.
Stroke, Oxygen and Prehospital Care: A Commentary on Current Treatments and Opportunities for Improvement
Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.
Caring for the Vulnerable and Disadvantaged
Ischemic stroke carries a high readmission rate [1]. Among Medicare beneficiaries hospitalized for acute ischemic stroke, 14.1% were readmitted within 30 days, 29.2% within 90 days, and 55.3% within 1 year [1].
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.
The Spread of Spectrin in Ataxia and Neurodegenerative Disease
Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies
Stroke, Oxygen and Prehospital Care: A Commentary on Current Treatments and Opportunities for Improvement
Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.
Commentary on Vulnerability and Resilience to Activity- Based Anorexia and the Role of Dopamine
Anorexia nervosa (AN) is an eating disorder characterized by a fear of gaining weight and self-starvation, leading to life-threatening weight loss [1]. It occurs predominately in women and frequently begins during adolescence.
Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease
Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tau
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke
Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.
Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics
Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].
A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans
Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.
In the Mind of the US Olympic Athletes; Longevity Advantage and Its Relation to Nervous System Disorders and Mental Illness
In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts.
Commentary: Use of BACTRAC Proteomic Database-Uromodulin Protein Expression During Ischemic Stroke
Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.
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