Journal of Experimental Neurology

We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.

Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations

Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Na_v1.1

Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.

Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.

Ischemic stroke carries a high readmission rate [1]. Among Medicare beneficiaries hospitalized for acute ischemic stroke, 14.1% were readmitted within 30 days, 29.2% within 90 days, and 55.3% within 1 year [1]. 

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.

We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.

Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies

Stroke is a common and very serious illness where timely evaluation and intervention can have dramatic effects on patient outcomes.

Anorexia nervosa (AN) is an eating disorder characterized by a fear of gaining weight and self-starvation, leading to life-threatening weight loss [1]. It occurs predominately in women and frequently begins during adolescence.

Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tau

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.

Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.

Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].

Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.

In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts. 

Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.