Journal of Experimental Neurology

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.

We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.

Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations

Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Na_v1.1

Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.

Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.

Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies

Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations

Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Na_v1.1

Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.

Methylphenidate (MPD) is a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, and is being increasingly misused as a recreational drug and cognitive enhancer

Minocycline is being tested in clinical trials for the treatment of stroke and traumatic brain injury. As an antibiotic it reduces microglia activation. Can minocycline be used to treat mild repetitive head injury? To that end, minocycline was tested in a novel, closed-head, momentum exchange model of repetitive mild head injury in female rats impacted while fully awake. Magnetic resonance imaging (MRI) revealed there was no brain damage or contusion attesting to the mild nature of the head impacts in this model.

Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.

Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.

Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].

Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.

In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts.