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Journal of Cellular Immunology

ISSN: 2689-2812

Commentary Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/immunology.2.015

Tenofovir at the Crossroad of the Therapy and Prophylaxis of HIV and HBV Infections

Erik De Clercq1,*
  • 1KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium
+ Affiliations - Affiliations

Corresponding Author

Erik De Clercq, erik.declercq@kuleuven.be

Received Date: November 18, 2019

Accepted Date: January 15, 2020

Citation:

De Clercq E. Tenofovir at the Crossroad of the Therapy and Prophylaxis of HIV and HBV Infections. J Cell Immunol. 2020; 2(1): 23-30.


Copyright: © 2020 De Clercq E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

For the treatment and/or prevention of HIV (human immunodeficiency virus) and HBV (hepatitis B virus) infections, 15 tenofovircontaining drug preparations have been commercialized: TDF (tenofovir disoproxil fumarate) and TAF (tenofovir alafenamide) for the therapy of HIV and HBV infections; TDF (or TAF) plus emtricitabine for the prophylaxis of HIV infections; TDF (or TAF) plus emtricitabine plus rilpivirine for the therapy of HIV infections; and several other tenofovir-containing drug combinations have been approved for the therapy of HIV infections: TDF (or TAF) plus emtricitabine plus elvitegravir plus cobicistat; TDF plus emtricitabine plus efavirenz; TAF plus emtricitabine plus bictegravir; TAF plus emtricitabine plus darunavir plus cobicistat; and TDF plus lamivudine with or without efavirenz or doravirine.

Keywords

HIV therapy; HIV prophylaxis; HBV therapy; Tenofovir disoproxil fumarate (TDF); Tenofovir alafenamide (TAF)

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