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Tertiary Prevention and Treatment for Reducing Leukemia Relapse
We have found little available information in the medical literature on the prevention and treatment of tertiary leukemia or patients' prognosis. We thus conducted a comprehensive literature review using the most recently updated American Society of Hematology guidelines, searching the MEDLINE and PubMed electronic databases by using the key term "progression-free survival (PFS) leukemia" and restricting results to the English language within the last decade.
Commentary on the Volume-Outcome Relationship in CRS/HIPEC for Peritoneal Carcinomatosis
Peritoneal carcinomatosis historically has a poor prognosis; however, Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) have shown improved outcomes. While a volume-outcome relationship is established in oncologic surgeries, its applicability to CRS/HIPEC remains unexplored. This study examines the impact of hospital volume on CRS/HIPEC outcomes.
Combining EGFR and KRAS G12C Inhibitors for KRAS G12C Mutated Advanced Colorectal Cancer
KRAS is a commonly mutated gene in advanced colorectal cancer (CRC). Recently, inhibitors of KRAS G12C were developed and have shown promising efficacy for KRAS G12C mutated non-small cell lung cancer. However, KRAS G12C inhibitor monotherapy has not demonstrated excellent efficacy for KRAS G12C mutated advanced CRC due to multiple resistance mechanisms, especially receptor tyrosine kinase (RTK) signaling activation.
The Role and Mechanism of Autoantibodies in Dysimmunity Related Neurological Diseases
Autoantibodies are antibodies produced by B cells capable of attacking their own tissues or organs after loss of immune tolerance. A large body of literature shows that autoantibodies play an important role in neurological diseases associated with immune abnormalities. Nowadays, neurological disorders are an important cause of disability and death in populations around the world, so it is important to study the role and mechanisms of autoantibodies in neurological disorders associated with immune abnormalities.
Atezolizumab Induced Neurotoxicity : A Systematic Review
Traditionally, cytotoxic chemotherapy dominated cancer treatment, but in recent years, immunotherapies, mainly immune checkpoint inhibitors (ICIs), have revolutionized cancer therapy by enhancing T-cell responses. Despite their efficacy, ICIs can induce toxicities affecting various organs, including the nervous system. Although rare, neurological complications of ICIs can be severe, contributing significantly to treatment-related mortality.
Gender Differences in the Association between Sedentary Time, Screen Time, and Depression
Previous research has indicated a relationship between sedentary time and depression, but it is unclear how this relationship differs by gender or subtype of sedentary behavior. This commentary expands our previous study on screen time, gender, and depression by examining relationships between sedentary time, gender, and depression. This additional analysis utilized the 2017- March 2020 National Health and Nutrition Examination Survey (NHANES).
Acute Urinary Retention Due to Non-Peuperal Uterine Inversion - A Case Report
Non-puerperal uterine inversion (NPUI) is an extremely rare cause of acute urinary retention in women of reproductive age. The delay in diagnosing this rare clinical entity presenting with acute urinary retention further complicates the management. The condition's rarity makes it difficult to carry out a study on its prevalence. Hence, most of the evidence comes from case reports or case series.
Australian School Based Interventions Addressing Child and Adolescent Mental Disorders: A Systematic Review
Aim: Prevalence of mental disorders in children and adolescents is between 3% to 30% worldwide. Since countries differ in geopolitical contexts, the World Health Organization (WHO) called for a coordinated effort to report on local contexts. We aim to address this gap by providing a review of effectiveness of Australian school-based mental health interventions and identifying success factors for school-based implementation.
A Work on the Treatment of Traditional Chinese Medicine Combined with Proton Pump Inhibitor (PPI) Step-down on Non-erosive Reflux Disease
We have published an article in Trials journal to carry out a multicentered, randomized controlled clinical trial on the treatment role of Traditional Chinese Medicine (TCM) combined Proton Pump Inhibitors (PPIs) step-down in non-erosive reflux disease (NRED). NRED is the most popular type of gastroesophageal reflux disease (GERD), which is defined as “the presence of abnormal acid exposure time (AET) with or without reflux–symptom association on ambulatory reflux monitoring performed off anti-secretory therapy” by Rome IV consensus.
Evolution of the Classification and Management of Smoldering Multiple Myeloma
The evolving molecular landscape of Smoldering Multiple Myeloma (SMM) has underscored its complex nature and the urgent need for more refined diagnostic and treatment strategies. With an increased risk of progression to Multiple Myeloma (MM), it has become important to identify patients at the highest risk of progression for interception strategies. Risk evaluation has been a constantly moving target with rapidly changing approaches to classification being based predominantly based on imaging and biochemical data thus far.
Association of Smoking and Crohn's Disease: An Update
The relationship between smoking and inflammatory bowel disease (IBD), which has been widely studied for years, is complex and different in Crohn's disease (CD) and ulcerative colitis (UC). The negative effect on CD, not only on disease progression and post-surgical recurrence, but also on post-surgical complications after intestinal resection, on its influence on the reservoir and on the modification of the natural evolution of CD towards fistulizing and stenosing forms, makes a proper approach to the problem imperative.
Majocchi Granuloma in the Face of an Immunocompetent Child: A Case Report
Introduction: Majocchi granuloma (MG) is a rare infection, generally caused by the dermatophyte Trichophyton rubrum. This disease results from the proliferation of the fungus along the hair follicle into the dermal or subcutaneous tissue, causing suppurative folliculitis. Most affected patients are immunocompromised, but it is not restricted to them. Its evolution is due to prolonged use of topical steroids.
Homology-Independent Targeted Insertion (HITI) for Therapeutic T-Cell Engineering
In this commentary we discuss our recent work on delivering an anti-GD2 CAR (chimeric antigen receptor) via homology independent targeted insertion (HITI) using the CRISPR/Cas9 technology. HITI relies on Non-Homologous End Joining (NHEJ) that is predominantly exploited by both dividing and non-dividing cells to repair double stranded DNA breaks (DSBs). We explore considerations when using HITI based strategies. Furthermore, we discuss a method for post-HITI CRISPR EnrichMENT (CEMENT) within the context of large-scale clinical manufacturing of non-viral CAR-T cells.
The Aryl Hydrocarbon Receptor as a Possible Novel Immunotherapy Target in Myeloma
Epidemiologic studies have demonstrated a possible association between exposure to environmental aromatic hydrocarbons and the development of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). These aromatic hydrocarbons bind the aryl hydrocarbon receptor (AHR) expressed by plasma cells that seem to promote development and survival of malignant cells.
Targeting Monocyte Abnormalities in Systemic Lupus Erythematosus through Omics-Based Drug Repurposing
Systemic Lupus Erythematosus (SLE) is a complex disease marked by extensive immune system dysfunction, culminating in a diverse spectrum of clinical phenotypes of varying severity. Despite the significant advancements in elucidating the pathogenesis of the disease, the management of SLE remains largely empirical with attainment of low disease activity and remission targets being an infrequent outcome among patients.
Gut Microbiota Metabolite Trimethylamine N-oxide Reduced Pancreatic β Cell Calcium Transients and Function
Pancreatic β cell dysfunction is an important cause of type 2 diabetes (T2D). Previous studies show trimethylamine N-oxide (TMAO), a gut microbiota-related metabolite, promotes cardiovascular disease and insulin resistance. However, the effect and mechanism of TMAO at pathological concentrations on β cell function remain unknown. The recently published work demonstrates TMAO reduces pancreatic β cell function and glucose homeostasis.
Epigenomics of Adaptive Plasticity of Rice Under Changing Climatic Conditions Grown by Direct-sowing as well as Transplanting
The common practice of cultivating rice through transplanting requires considerably higher amount of water, which poses several challenges, particularly in the present era of global climate change and decreasing availability of water. The direct-sown rice (DSR) presents a promising/resource-saving alternative for cultivation of rice in the current scenario of changing climatic conditions. While some local cultivars are well-adapted for DSR, there has been limited success in breeding for DSR varieties.
Biosynthesis of Manganese Dioxide Nanoparticles and Optimization of Reaction Variables
Biosynthesis is an efficient and environmentally friendly process used to synthesize nanoparticles. This study presents a simple, environmentally friendly, and cost-effective method for synthesizing manganese dioxide nanoparticles from aqueous manganese (II) acetate using lemon extract as a reducing agent. Turmeric extract (curcumin) was employed to stabilize the biosynthesized nanoparticles. UV-visible spectroscopy was used to evaluate the concentration of nanoparticles at 350 nm wavelength.
A Review Study on the Sources of Biosynthesis of Nanoparticles from Different Organisms and Their Applications in Nanomedicine
Nowadays nanoparticles is gaining much attention across the world among the researchers. From last few decades, green nanotechnology also emerging as a significant approach in order to synthesize and fabricate the nanoparticles from different organisms. This green route stabilizing the agents from biological agent for the formation of nanoparticles. The present review article aims is to elaborate the ongoing emergence of nanoparticle formulation from different microbiota.
Non-Invasive Pelvic Floor Rehabilitation in Cancer Population
The pelvic floor (PF) is a complex network of muscles and ligaments that serves as a crucial structural support for various pelvic organs, including the bladder, urethra, prostate, vagina, uterus, anus, and rectum, while also indirectly supporting intra-abdominal contents. It forms a hammock-like supportive layer embedded from the pubic bone to the sacrum/coccyx and ischial tuberosities.
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