Articles

Music listening and schizophrenia substantially involve emotion, subjective experience, motivation, and cognition in a complex manner. Despite these similarities, existing research appears to offer limited synthesis of their shared neuroscientific foundations. Accordingly, this narrative review integrates findings on the neural mechanisms underlying music listening and schizophrenia, based on analyses of peer-reviewed journal articles retrieved from PubMed, PsycINFO, and Nature Research databases, to specifically address their neurobiological parallels.

The aim of this study was to evaluate the long-term effects of continuous subcutaneous insulin infusion (CSII) therapy on the improvement of metabolic control and beta-cell function in patients with type 2 diabetes mellitus. A single-center retrospective observational study was carried out in patients with T2DM who required CSII therapy due to suboptimal glycemic control. T2DM patients treated with the DANA-R Diabe care insulin pump (SOOIL Development Co., Ltd.) was followed for 6 years.

Recent reports and ongoing clinical trials demonstrate potential roles for cancer vaccine therapy in a number of malignancies [1]. Adaptive cellular immune responses are required for protective immunity when vaccines are used against infectious diseases [2]. For therapeutic cancer vaccines used to treat established tumors, elaboration of durable T cell mediated responses are also understood to be necessary for efficacy [3–5]. Immune responses measured in peripheral blood lymphocytes correlate with clinical outcomes [6,7]. 

The rapid pivot to online learning during the COVID-19 pandemic has permanently transformed education, elevating e-learning to a global mainstream modality while exposing new opportunities and challenges. This paper summarizes the study from Kaufmann et al. (2022), and examines professional education in the context of the Erasmus+ Ka226 Project, focusing on the interplay between instructional, technological, and mental health paradigms that underpin inclusive online collaborative learning.

Pleomorphic rhabdomyosarcoma (PRMS) is a rare and aggressive soft tissue sarcoma that typically occurs in the extremities of older adults. Involvement of the splenic hilum is extremely rare and has not been previously reported in the literature. We present the case of an 81-year-old female with a remote history of high-grade serous carcinoma of the ovary who presented with new-onset vaginal bleeding. Imaging revealed a mass in the left upper quadrant at the interface of the spleen and pancreatic tail.

Elaboration and extensions are provided of an earlier article on the application of time-series-based single-case intervention designs (SCIDs) and analyses for researchers in the health sciences. The research potential, as well as the strengths and weaknesses of such designs, are detailed.

Bile duct injury (BDI) is one of the most serious complications of cholecystectomy associated with substantial risk of morbidity and mortality. Although surgical techniques have evolved, bile duct injuries continue to occur with notable frequency. To evaluate the demographic profile, presentation, classification, management, and outcomes of patients with BDI following laparoscopic cholecystectomy.

Chimeric antigen receptor (CAR) T cell therapy has achieved unprecedented success in hematologic malignancies, yet its application in solid tumors remains fraught with challenges. Key barriers include antigen heterogeneity, limited tumor infiltration, and most critically, the profoundly immunosuppressive tumor microenvironment (TME). This editorial synthesizes current research to detail the multifaceted suppressive effects of the TME on CAR-T cells, reviews innovative strategies being developed to overcome these barriers, and discusses the future trajectory of CAR-T therapy for solid tumors.

We present a case of apical hypertrophic cardiomyopathy (AHCM), also known as Yamaguchi syndrome, in a young female with no family history. She presented after recurrent syncopal events with cyanosis, palpitations and was found to have diffuse T-wave inversions and a pattern of left ventricular hypertrophy on ECG. 

Triple-negative breast cancer (TNBC) is responsible for 10–20% of breast cancer cases and is associated with poor prognosis and limited treatment options due to the lack of expression of hormone and HER2 receptors. Kojic acid dipalmitate (KDP) is best known for its skin depigmenting activity; however kojic acid derivatives have shown promising antitumor activity. Such potential remains unexplored for KDP in breast cancer. 

Access to safe anesthesia care remains one of the most profound inequities in global health. Bridging the gap between evidence and policy, this article argues that integrating nurse anesthesia within advanced practice nursing frameworks offers a viable and ethical pathway toward global health equity.

Higher left ventricular filling pressure (LVFP) is often associated with non-fluid responsiveness in heart failure patients, particularly those with reduced ejection fraction. This hemodynamic state has been linked to adverse outcomes, including higher rates of rehospitalization and mortality. However, the prognostic implications of fluid responsiveness assessed after decongestion remain uncertain.

Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma (CTCL). Tumor-derived exosomes are endosome-derived extra-cellular-vesicles secreted by cancer cells to create tumor favorable niche. We previously demonstrated that MF-exosomes deliver a significant load of miR-155 and miR-1246 into recipient cells and increase their motility. 

Conventional chemotherapy is limited by systemic toxicity, poor tumor penetration, and drug resistance. While mechano-chemo therapy combining mechanical stimulation with chemicals shows promise, existing techniques are in the early stages. A bubble-free acoustofluidic platform using high-frequency surface acoustic waves to apply localized mechanical forces, named ChemoTAP, was developed.

The concurrent use of tramadol and khat has been increasing in Ethiopia, raising concerns about their potential neurocognitive consequences. Despite growing trend, the effects of combined tramadol and khat exposure on learning and memory (LM) have not been previously investigated. Accordingly, the present study was designed to evaluate the impact of co-administration of khat and tramadol on spatial learning and memory in a mouse model.

The diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is challenging due to its variable clinical presentation and long latency period. We report a case of a woman in her 60s who developed Vancomycin-induced DRESS after treatment for cellulitis and septic arthritis.

Myocardial infarction (MI) leads to progressive left ventricular (LV) remodeling, significantly affecting patient outcomes and prognosis. This paper provides a critical overview of the current standard of care and emerging pharmacological and regenerative therapies for prevention of cardiac remodeling post-MI.

This study investigates the role of Calcium Homeostasis Modulator 6 (CALHM6) in immune regulation during SARS-CoV-2 infection, with the aim of exploring its potential as a prognostic marker. Peripheral blood mononuclear cells (PBMCs) from 42 SARS-CoV-2 positive patients and 19 healthy controls were analyzed for CALHM6 expression. Clinical data were collected from patients admitted with low oxygen saturation (≤90%) and severe symptoms, and RNA was extracted at admission.

Autoimmune diseases primarily mediated by cellular immunity, classified as type IV hypersensitivity disorders, are driven by dysregulated T cell responses resulting in targeted tissue destruction. Unlike antibody-dominant autoimmune conditions, these disorders involve autoreactive CD4⁺ and CD8⁺ T cells that infiltrate tissues, amplify inflammatory cascades, and promote chronic organ damage through cytokine release and direct cytotoxicity. 

Currently, newer strategies are being implemented regarding WATCHMAN placement in the community hospital, such as same-day discharge (SDD). The safety of this protocol needs to be further assessed. The study aimed to evaluate the outcomes of SDD versus non-SDD in patients with nonvalvular atrial fibrillation who underwent WATCHMAN placement by comparing baseline demographics and post-procedure outcomes.