Loading
Assessment of Stability of Early Loaded Nano Coated Hydroxyapatite Implants in Posterior Maxilla
Aim: The aim of the study was to assess the stability after early loading of nano coated hydroxyapatite implants in posterior maxilla. Methodology: This study was conducted on nine patients with at least a missing one maxillary posterior tooth. Ten Nano-coated hydroxyapatite implants (ETIII NH implant by Hiossen) were inserted in nine patients, and then subjected to early loading according to the secondary stability readings taken by Osstell®.
Therapeutic Pathology- The Pathology of Tomorrow
As pure science, pathology has always been the backbone of every aspect of diagnosis in medical practice. Although the main focus has been on the classification of the disease entities and their association with the prognosis of the condition, the focus has been shifting towards more practical applications- the ‘therapeutic uses’.
Retesting of Neonatal Hearing Screening Before and During the COVID-19 Pandemic: A Longitudinal Study
Introduction: Universal Newborn Hearing Screening (UNHS) plays an essential role in the early identification of hearing loss in neonates. Risk factors for hearing impairment may include family history, prematurity, and exposure to ototoxic substances. Coronavirus Disease 2019 (COVID-19) might be a significant contributing factor affecting the structures of the inner ear.
Optical Insights into Fibrotic Livers: Applications of Near-Infrared Spectroscopy and Machine Learning
Liver fibrosis staging is critical for patient selection and management prior to transplantation, but biopsy is invasive and serum biomarkers lack accuracy. Near-infrared spectroscopy (NIRS) is an emerging non-invasive technology that can detect liver fibrosis via changes in tissue composition. Machine learning (ML) enables analysis of NIRS data for diagnostic modeling.
Colonic Granular Cell Tumor
A 42-year-old asymptomatic woman presented for routine health checkup. Abdominal examination was unremarkable. The laboratory tests were normal. The chest radiograph, upper gastrointestinal endoscopy and abdominal computed tomography showed no abnormal findings. A colonoscopy was performed. A hepatic flexure polypoid mass (8 × 8 mm in diameter), covered with normal-appearing mucosa, was identified (Figure 1A).
The Role of Tumor and Host Microbiome on Immunotherapy Response in Urologic Cancers
The role of the microbiome in the development and treatment of genitourinary malignancies is just starting to be appreciated. Accumulating evidence suggests that the microbiome can modulate immunotherapy through signaling in the highly dynamic tumor microenvironment. Nevertheless, much is still unknown about the immuno-oncology-microbiome axis, especially in urologic oncology. The objective of this review is to synthesize our current understanding of the microbiome’s role in modulating and predicting immunotherapy response to genitourinary malignancies.
Role of a Training Simulator for Kidney Biopsy and Tumor Removal Procedures in Complex Positioning Scenarios: The Key Challenges
Preventable medical errors and iatrogenic injuries remain significant contributors to mortality and morbidity, emphasizing the need for effective clinical training methodologies. Traditional teaching methods often inadequately prepare physicians for mastering procedural skills. Surgical procedures like nephrectomy for kidney tumor removal require intricate understanding of renal anatomy and meticulous technique. Close coordination among the specialists remains crucial to ensure optimal patient outcomes.
Luminescent MOFs Based on Thiazolo[5,4-d]thiazole as a Chemosensor for the Detection of Environmental Contaminants
Luminescent metal-organic frameworks (LMOFs) are considered special candidates for the sensation and detection of particular analytes. Thiazolo[5,4-d]thiazoles (TTZs) are an ideal type of heterocycles for fluorophores with π-bridge moieties demonstrating structure-function characteristics. LMOFs with excellent sensing properties can be constructed by incorporating heterocyclic aromatic thiazolo[5,4-d]thiazole into the framework.
The Effect of Nano-Encapsulated Orlistat on Prostate Cancer: An In vitro Study
Background: The targeted inhibition of fatty acid synthase (FASN) by Orlistat, a potent FASN inhibitor, has been shown to block tumor proliferation and induce apoptosis in cultured tumor cells. Since Orlistat is insoluble, its solubility in blood circulation is limited. Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems.
Phorbol-12-Myristate-13-Acetate (PMA) Reactivates Replication from HIV-1 Latency and Induces Jurkat Cell Death
HIV-1 has the capability to establish latency during early infection in CD4+ cells, posing a significant challenge to the efforts aimed at curing HIV-1/AIDS. One extensively explored strategy to address this viral latency is the "shock-and-kill" approach. This involves reactivating viral replication using latency reversal agents (LRAs) to induce the death of infected cells. Regrettably, no LRAs with proven effectiveness have been identified thus far.
Role of Exosomal MicroRNAs in Modulating the Response of Cancer Cells to Paclitaxel Treatment
MicroRNAs (miRNAs) play important roles in gene regulation and have been implicated in various human diseases, including cancer. MiRNAs can be packaged in exosomes and transferred between cells. These exosomal miRNAs regulate intercellular communication and influence almost all aspects of cancer biology, including proliferation, apoptosis, invasion, metastasis, and angiogenesis.
Ephrin B1 Regulates Inflammatory Pathways in Retinal Müller Cells
The role of inflammation has been accepted as a factor in the complications of diabetic retinopathy. Discovery of the upstream regulation of these inflammatory factors has remained a challenge. In this study, we explored the actions of ephrin B1 in retinal Müller cells and their actions on inflammatory proteins. We used diabetic human and mouse samples, as well as Müller cells in culture to measure ephrin B1 in Müller cells.
MKP-2 Deficiency Leads to Lipolytic and Inflammatory Response to Fasting in Mice
The liver plays a crucial role in maintaining homeostasis for lipid and glucose. Hepatic lipid synthesis is regulated by nutritional signals in response to fasting and refeeding. It is known that overnutrition regulates MAPK-dependent pathways that control lipid metabolism in the liver by activating MAPK phosphatase-2 (MKP-2). Uncertainty still exists regarding the regulatory mechanisms and effects of MKP-2 on hepatic response to fasting.
Monitoring Transcription of miR-15a and miR-124 in Mesenchymal Stem Cells from Adipose Tissue Origin Differentiated into Pancreatic Beta-cells
MicroRNAs are small, noncoding pieces of nucleic acid with the potential to control mRNA translation. These sequences participate in the regulation of cell dynamic growth and differentiation. In this study, the expression of miR-15a and miR-124 was monitored in adipose-derived tissue stem cells committed to pancreatic β cells in vitro over 28 days. In the current experiment, adipose-derived mesenchymal stem cells were incubated in an induction medium to accelerate differentiation toward the endocrine pancreatic lineage for 28 days with a three-stage protocol.
Hair Follicle Stem Cells: the Signaling Hub of the Skin
Hair follicle stem cells (HFSCs) are recognized as multipotential stem cells with exceptional proliferative capacity. Their regulatory effect on skin homeostasis is orchestrated through intricate signaling pathways, including Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein (TGFβ/BMP), Notch, and Hedgehog.
Treatment of Sleep Disorders in Children with Atopic Dermatitis: What's New?
Atopic dermatitis (AD), also known as atopic eczema, is a chronic and inflammatory disease caused by an interaction of genetic, immunological, and environmental factors. It is characterized by skin lesions and itching and progresses with periods of improvement and worsening.
Predatory versus Non-Predatory Journals: An Important Distinction to be Made
The term, “predatory”, is defined in Webster’s dictionary as “inclined or intended to injure or exploit others for personal gain”. This term was first applied to some journals by Professor Beall in 2012, describing those journals as being without scholarly merit and being exploitative for a journal’s gain.
Sexual Abuse of Minors: 63 Cases at Mouila Regional Hospital in Gabon in 2022
Sexual abuse of a minor is defined as any sexual violation or act of a sexual nature committed against a human being under the age of eighteen, by violence, coercion, threat, surprise, or deception [1]. Similarly, rape of a minor is any act of sexual penetration of any kind committed against a human being under the age of eighteen using violence, coercion, threats, or deception [1].
Atypical Presentation of Tibia and Fibula Fracture in an Old Woman - Case Report
This case report presents the clinical details, diagnostic findings, and management of a 64-year-old female patient who suffered a tibia and fibula fracture, presented in an atypical manner, after twisting her ankle during daily activities. The medical background, physical examination, radiological results, and course of treatment of the patient are detailed.
Aldosterone Synthase Inhibitors for Treatment of Hypertension and Chronic Kidney Disease
Aldosterone excess is known to worsen hypertension and kidney function. Three selective aldosterone synthase inhibitors (ASIs) were evaluated in 3 phase 2 trials. In the first study, the ASI baxdrostat 2 mg orally once daily decreased systolic blood pressure (SBP) by 11.0 mmHg compared with placebo after 12 weeks in patients with treatment-resistant hypertension. In the second study including patients with uncontrolled hypertension, placebo-corrected reduction in SBP with lorundrostat 50 mg once daily was 9.6 mmHg after 8 weeks.
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.