Articles

Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma (CTCL). Tumor-derived exosomes are endosome-derived extra-cellular-vesicles secreted by cancer cells to create tumor favorable niche. We previously demonstrated that MF-exosomes deliver a significant load of miR-155 and miR-1246 into recipient cells and increase their motility. 

Conventional chemotherapy is limited by systemic toxicity, poor tumor penetration, and drug resistance. While mechano-chemo therapy combining mechanical stimulation with chemicals shows promise, existing techniques are in the early stages. A bubble-free acoustofluidic platform using high-frequency surface acoustic waves to apply localized mechanical forces, named ChemoTAP, was developed.

The concurrent use of tramadol and khat has been increasing in Ethiopia, raising concerns about their potential neurocognitive consequences. Despite growing trend, the effects of combined tramadol and khat exposure on learning and memory (LM) have not been previously investigated. Accordingly, the present study was designed to evaluate the impact of co-administration of khat and tramadol on spatial learning and memory in a mouse model.

The diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is challenging due to its variable clinical presentation and long latency period. We report a case of a woman in her 60s who developed Vancomycin-induced DRESS after treatment for cellulitis and septic arthritis.

Myocardial infarction (MI) leads to progressive left ventricular (LV) remodeling, significantly affecting patient outcomes and prognosis. This paper provides a critical overview of the current standard of care and emerging pharmacological and regenerative therapies for prevention of cardiac remodeling post-MI.

This study investigates the role of Calcium Homeostasis Modulator 6 (CALHM6) in immune regulation during SARS-CoV-2 infection, with the aim of exploring its potential as a prognostic marker. Peripheral blood mononuclear cells (PBMCs) from 42 SARS-CoV-2 positive patients and 19 healthy controls were analyzed for CALHM6 expression. Clinical data were collected from patients admitted with low oxygen saturation (≤90%) and severe symptoms, and RNA was extracted at admission.

Autoimmune diseases primarily mediated by cellular immunity, classified as type IV hypersensitivity disorders, are driven by dysregulated T cell responses resulting in targeted tissue destruction. Unlike antibody-dominant autoimmune conditions, these disorders involve autoreactive CD4⁺ and CD8⁺ T cells that infiltrate tissues, amplify inflammatory cascades, and promote chronic organ damage through cytokine release and direct cytotoxicity. 

Currently, newer strategies are being implemented regarding WATCHMAN placement in the community hospital, such as same-day discharge (SDD). The safety of this protocol needs to be further assessed. The study aimed to evaluate the outcomes of SDD versus non-SDD in patients with nonvalvular atrial fibrillation who underwent WATCHMAN placement by comparing baseline demographics and post-procedure outcomes.

Mycobacterial inorganic pyrophosphatase (Mt-PPa) plays an essential role in Mycobacterium tuberculosis survival both in vitro and in vivo. This enzyme family hydrolyzes inorganic pyrophosphate (PPi) to release inorganic phosphate (Pi), thereby preventing pyrophosphate toxicity. The M. tuberculosis gene Rv3628 encodes a type I inorganic pyrophosphatase that exhibits metal-ion-dependent catalytic activity.

Insects conform large numbers of parasites and pathogens in diverse habitats. Cuticular structures on their body surfaces and secreted membranes in their digestive tracts are the first defensive barriers to prevent entry of invading organisms. Across the extended range of genera and species, insects acquired common first front defensive mechanisms. 

Metabotropic glutamate (mGlu) receptors are a family of G protein-coupled receptors. These receptors are widely distributed in the brain and are critical for the modulation of synaptic transmission and plasticity. Emerging evidence shows that mGlu receptors themselves are subject to a dynamic posttranslational modification involving protein ubiquitination. 

Methamphetamine-induced psychosis (MIP) usually resolves within days to weeks after stopping drug use. However, some vulnerable individuals may experience prolonged symptoms. We present the case of a woman who developed long-lasting psychotic symptoms following minimal methamphetamine exposure, shedding light on risk factors and the importance of holistic care.

The purpose of this study is to perform an analysis of 51 community health needs assessments (CHNAs) qualitatively and quantitatively (mixed methods) for evidence of the presence or lack of the identification of syndemics, which is defined as two or more physiological conditions, exacerbated by a cultural factor that gives rise to a health problem. This research uses a book chapter titled, Suicide as Syndemic—physiological effects of high altitude and physiological and behavioral manifestations of mental illness, exacerbated by the Cowboy Culture as a referent.

Defining profound intellectual disability remains a major clinical and conceptual challenge. Traditional approaches have sought criteria such as an estimated IQ below 20 or developmental-age equivalence under 24 or 36 months. However, these criteria are of limited utility when cognitive impairment is combined with severe motor, sensory, and health-related disabilities.

This paper examines the consequence of the prevalence of disability on eligible rural households’ voluntary enrolment decisions in Ethiopia's community-based health insurance scheme in Ethiopia. It uses data from the Ethiopian Socio-Economic Survey and estimates the multivariate probit model.

For decades, psychopharmacology has focused on chemical modulation rather than biological repair. Emerging evidence across cellular, molecular, and systems neuroscience suggests that the adult brain retains dormant capacities for renewal that can be pharmacologically reactivated. Regenerative pharmacology reframes treatment as a process of biological reactivation, reawakening latent plasticity to rebuild damaged circuits rather than merely stabilizing neurotransmission.

Intellectual disability (ID) is a highly heterogeneous neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning. Comprehensive cognitive and adaptive behavior assessments are essential for investigating its underlying causes. While environmental factors contribute, particularly in mild cases, genetic etiologies predominate in moderate to severe forms, accounting for over 50% of these cases. This review explores the complex genomic architecture of ID, including chromosomal abnormalities, monogenic disorders, de novo mutations, polygenic inheritance, and epigenetic dysregulation.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the management of refractory hematologic malignancies such as leukemia, lymphoma and multiple myeloma, offering unprecedented remission rates. Yet, complications arising from infections remain a major challenge, particularly in the early post-infusion period and during prolonged immune suppression. This editorial synthesizes recent evidence (2021–2025) on infection epidemiology, risk factors, and stewardship strategies in CAR T-cell recipients.

Will SARS-CoV-2 continue to evolve in such a way that the risk of long COVID may one day become negligible? Theoretically, it's possible, but based on what we've seen so far, it's quite doubtful.
Long COVID is a debilitating and persistent illness that affects people in multiple and dynamic ways. It occurs after a SARS-CoV-2 infection and manifests as a continuous, relapsing-remitting, or progressive disease state affecting one or more organ systems. It can occur after an asymptomatic, mild, or severe SARS-CoV-2 infection.

Primary angiitis of the central nervous system (PACNS) is a rare form of single-organ vasculitis, as classified by the 2012 Chapel Hill Consensus Conference. It affects small- and medium-sized vessels within the brain and spinal cord, arises independently of systemic disease, manifests with heterogeneous clinical features, and remains without definitive diagnostic biomarkers.