Articles

Recently it became obvious that drug abuse, infectious disease, and hematologic dysregulation are not peripheral concerns—they are central determinants of therapeutic success or failure. Late-stage metastatic cancer remains one of the most pharmacologically unforgiving landscapes in modern medicine. Despite decades of therapeutic innovation, the microenvironments that support disseminated tumor cells have evolved into highly specialized, treatment-resistant ecosystems.

The doctor-patient relationship is fundamental for both diagnosis and treatment. All healthcare activity is influenced, directly or indirectly, by interpersonal relationships. Communication allows for the integration of clinical reasoning by connecting the biomedical and psychosocial aspects of clinical care. It is about integrating communication and clinical reasoning, and connecting the biomedical and psychosocial aspects of clinical care.

Background/Aim: Matrix metalloproteinase-9 (MMP-9) is considered to be implicated in progression of dental diseases such as dentin caries and erosion. In this study, the effects of some metal salts composed of any of Mg²⁺, Ca²⁺, Zn²⁺ and either lactate ion or acetate ion on MMP-9 activity were examined.

Glucagon-like peptide-1 (GLP1) and receptor (GLP1R) agonists are now in common use for treating type 2 diabetes mellitus and weight loss as major global health burdens affecting millions worldwide with prevalence of both diagnosed and undiagnosed diabetes approaching 15% for all U.S. adults increasing with age (www.cdc.gov/diabetes/php/data-research/index.html).

Stroke is a medical emergency where blood supply to the brain is cut off (ischemic) or a blood vessel ruptures (hemorrhagic), leading to potential long-term damage, disability, or death. Transcranial magnetic stimulation (TMS) is used in neurological conditions as a non-invasive form of brain stimulation and can promote motor function recovery after a stroke. There is literature demonstrating improvement with high and low-frequency rTMS in stroke patients; however, the literature on these frequencies is limited. 

The field of computational engineering is undergoing a profound transformation, driven by the rapid integration of artificial intelligence (AI) into traditional modelling and simulation paradigms [1].

Myopathies constitute a heterogeneous group of disorders defined by impaired skeletal muscle functions that originate from structural, metabolic, genetic, or inflammatory abnormalities. At the biochemical level, these conditions are characterized by significant disruptions in essential processes, including energy metabolism, calcium homeostasis, and redox balance.

Blood-based biomarkers have demonstrated strong performance for identifying cerebral amyloid pathology within individual cohorts. However, their clinical utility depends on portability across populations and assay platforms. The impact of cross-cohort deployment on clinically actionable metrics such as negative predictive value remains insufficiently characterized. We analyzed data from two independent cohorts: the Alzheimer’s Disease Neuroimaging Initiative (n = 885) and the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease study (n = 822). 

Previous studies have reported inconsistent findings regarding the association between H. pylori  infection and overweight/obesity. This study aims to evaluate the clinical and anthropometric characteristics of children and adolescents with chronic abdominal pain, grouped as follows:(1) non-ulcer dyspepsia with confirmed H. pylori gastritis, and (2) dyspepsia with confirmed chronic esophagitis and without H. pylori  infection. This single-center, observational, retrospective case-control study used a convenience sample of children and adolescents referred for chronic abdominal pain and non-ulcer dyspepsia.

A Monteggia fracture is a fracture of the proximal ulna with radial head dislocation. The Bado classification is frequently used, though it does not cover all patterns. Type 1 is the most common, while Types 3 and 4 are rare. A rare complication is radial nerve palsy, particularly posterior interosseous nerve palsy, which usually manifests as neuropraxia and resolves spontaneously.

Aims: The present study investigated Runt-related transcription factor 2 (RUNX2) and collagen type A1 (COL1A1) gene expressions in pseudarthrosis with the objective of creating a novel shaft femoral pseudarthrosis rabbit model.

Screening for type 1 diabetes (T1D) can be challenging, causing diagnostic delay and potentially serious health consequences. Continuing education (CE) in T1D is lagging but could help improve clinician knowledge of and engagement in T1D screening behaviors. his retrospective, case-control study assessed pre-/post-changes in clinician knowledge of T1D screening and management (N=4817) following exposure to an interactive, multicomponent CE program (DETECT T1D) from May 2024 to January 2025.

Parkinson's disease (PD) is a neurodegenerative disorder involving motor and non-motor symptoms that reduce quality of life. Non-motor symptoms, including depression, anxiety, fatigue, and sleep disturbances, are often underrecognized despite their significant impact on daily functioning. This study aimed to examine the effects of three group-based rehabilitation interventions on emotional well-being in patients with moderate PD.

Clinical testing is essential in establishing the etiology of non-traumatic Rotator Cuff Related Shoulder Pain. To assess the Sensitivity and Specificity of the Painful Arc test, the Neer test, the Hawkins-Kennedy test, the Jobe or Empty Can test and the Cross-Body-Adduction test in different pathologies of non-traumatic Rotator Cuff Related Shoulder Pain such as bursitis, cuff tendinopathy and cuff tear.

 Post-COVID syndrome (PCS) affects about 10% of COVID-19 patients, causing persistent symptoms such as chronic fatigue, cognitive impairments, and depression. These symptoms reduce quality of life and work capacity and are therefore targeted in specialized rehabilitation programs. A rehabilitation center in Germany developed a four-week group-based PCS rehabilitation program focusing on energy management.

Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening thrombotic microangiopathy (TMA) caused by complement dysregulation, often leading to end-stage renal disease and death. Recent real-world and post-marketing surveillance studies underscore the critical importance of initiating eculizumab, a terminal complement inhibitor, within seven days of disease onset, which is associated with sustained inhibition of TMA and marked improvement in renal outcomes and survival compared with delayed treatment. 

This commentary outlines the research background of the paper “Berufliche Identitätsarbeit als subjektzentrierter Paradigmenwechsel einer transformativen Berufsbildung für nachhaltige Entwicklung (BBNE)” [Vocational identity work as a subject-centered paradigm shift in transformative VET for ESD] and examines its implications for health promotion in vocational education and training (VET). It focuses on the health-promoting potential of identity-based VET didactics within dual systems such as in Germany and introduces relevant theoretical, methodological, and didactic approaches.

Vertebral augmentation (VA) encompasses percutaneous vertebroplasty and kyphoplasty, with or without the integration of expandable intravertebral implants (EII), is a primary intervention for the management of painful vertebral compression fractures, including those of a pathologic nature secondary to cancer. The procedure involves the targeted injection of polymethylmethacrylate (PMMA) or analogous bone cement into the fractured vertebral body to achieve mechanical stabilization and subsequent analgesia.

Three quarters of all medical errors stem from cognitive error, rather than the systemic errors that most efforts address. This narrative/conceptual review posits that many clinicians are not fully aware of or sufficiently focused on the innate cognitive processes our brains use for clinical reasoning.

Background: Spontaneous ovarian hyperstimulation syndrome (sOHSS) is a rare condition in naturally conceived pregnancies, characterized by ovarian enlargement and extravascular fluid accumulation.