Articles

This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.

Nowadays, as a standard of care treatment of several cancers, immune checkpoint inhibitors have changed the field of oncology. However, their empowerment of T cell-mediated anti-tumor immunity bears the risk for injury of various organs as a side effect.

Chemo-immunotherapy has shown great promise as a next-generation treatment strategy for established solid tumors. Cheng et al. first developed the PD-L1- and CD44-responsive multifunctional nanoparticles (MNPs) utilizing a polymer complex of polyethyleneimine and oleic acid (PEI-OA) and loaded with two chemotherapeutic drugs (paclitaxel and chloroquine), an antigen (ovalbumin), an immunopotentiator (CpG), and an immune checkpoint inhibitor (anti-PD-L1 antibody).

Spinal cord injury (SCI) is a devastating disease that has a global impact on individuals and society. The number of SCI cases in 2016 was 27 million worldwide, which was predominantly due to falls and road traffic collisions. Alarmingly, the number of new SCI cases in most countries has risen over the last few decades.

A 69-year-old woman with hypertension, hyperlipidemia, sleep apnea, gastroesophageal reflux disease, and recent knee replacement was brought to the emergency room (ER) for syncope. She had her physiotherapy session earlier in the day and became symptomatic with dizziness, shortness of breath and had loss of consciousness.

Bannayan-Zonana syndrome (BRRS) is a rare genetic disorder characterized by macrocephaly, numerous soft tissue and visceral hamartomas, and lipomas. Because of the risk of fatal bleeding and visceral neoplasia in adulthood, recognizing this disease is critical.

Ogilvie syndrome, also known as “paralytic ileus of the colon,” is characterized by pseudo- obstruction of the colon without any component of mechanical obstruction; and presents as a massively distended abdomen. If left untreated, it carries a high risk of colonic perforation and ischemia leading to death.

Percutaneous coronary angiography and interventions have become essential diagnostic and therapeutic tools in coronary artery disease management. Vascular closure devices were introduced in the early 1990s. They provided a safe, reliable, and efficient method to achieve puncture site hemostasis. Collagen-based vascular closure devices are frequently used modalities.

A normally developed tooth that cannot erupt in the maxillary or mandibular dentition after its normal eruption age is likely to be an impacted tooth. Radiographic confirmation suggests that it will not erupt in its dental arch [1]. The most commonly impacted teeth are the mandibular third molars followed by permanent maxillary canines. Langberg quoted “no tooth is more interesting from a developmental point of view than the maxillary canine” [2].

HCC is one of the most common malignant tumors. The life and health of humans are gravely threatened by HCC because of its hidden onset, high recurrence rate, poor therapeutic effect, and high mortality. It is essential to explore the particular pathological mechanisms of HCC in order to increase the rate of early diagnosis and enhance patient therapy outcomes.

Use of platelet-rich plasma (PRP) is well established in treatment of orthopedic patients. This pilot study aims to determine the efficacy of using instillation of PRP paired with hydrodistention of the bladder to treat patients with interstitial cystitis (IC).

The increase in infertility around the world has a negative impact on sexual desire and function. The objective of this study was to evaluate the presence of sexual dysfunction in women diagnosed with infertility, comparing them with healthy controls.

The present study aimed to study the vaccination acceptance of COVID-19 vaccine in the Hellenic pregnant population and make a high relative analysis of the factors that contribute to decision-making concerning the acceptance of the vaccine during pregnancy. Findings could be leveraged for improving the vaccination communication strategy to pregnant women to increase the vaccination acceptance rate.

Globally, an estimated 4.2 million people above the age of 50 now have diagnosis of HIV (Human Immunodeficiency Virus) infection. Patients with HIV can now survive well into old age. Aging with HIV has been associated with medical illness however neuropsychiatric symptoms including cognitive decline and behavioral dysregulation has been directly associated with aging and having HIV.

The standard treatment options for Coronavirus disease 2019 (COVID-19) remain challenging despite community vaccinations and reduced mortality. As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to evolve and new strains emerge, diversity in the use of existing antiviral drugs has become a crucial therapeutic tool in combating the COVID-19 epidemic.

The SARS-CoV-2 virus, responsible for covid-19, had an animal origin and jumped to humans in 2019. In 2020 alone, COVID-19 infected almost 100 million people around the planet and ended with the lives of 2 million people. The development in a very short space of time, of vaccines against COVID-19, in response to the urgency of the pandemic, is a transcendental milestone in the history of medicine.

Understanding the mechanism of bidirectional interaction between different angles of the death triangle is a lifesaving novel idea that I invented in 2018. Platelet hyperactivity and dysfunction in diabetes and cancer patients were already known facts [1] but whether different COVID-19 variants could activate and/or accelerate death triangle machinery?

Granulocyte-colony stimulating factor (G-CSF) has been in clinical use for over two decades to enhance hematopoiesis and granulopoiesis to increase the numbers of hematopoietic stem/progenitor cells in patients with neutropenia and patients involved in bone marrow transplantation. G-CSF protein or G-CSF gene therapy has also been shown to have both neuroprotective and neurogenesis function and is quite effective in improving neurological functions in Parkinson’s disease [1], stroke [2-4] and Alzheimer’s disease [5].

Venetoclax, a small-molecule B-cell lymphoma 2 (BCL-2) inhibitor, selectively eradicates leukemic stem cells (LSCs). While venetoclax has revolutionized the treatment of acute myeloid leukemia (AML), treatment failure and disease relapse are common. Mechanisms underlying venetoclax resistance are surprisingly heterogeneous.

Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection is a serious threat to lung cancer patients. Hereby, we hypothesize that Coronavirus disease 2019 (COVID-19) may contribute to lung cancer progression by increasing extracellular adenosine triphosphate (ATP) levels and hyperactivating the purinergic P2X purinoceptor 7 receptor (P2X7R).