Articles

Transcatheter aortic valve replacement (TAVR) is currently the most commonly utilized management strategy for severe aortic stenosis. The short-term outcomes of TAVR in patients who experienced a recent acute myocardial infarction (AMI) remain unclear.

This commentary extends Chapter 14, Mental Health First Aid Certification to Build Capacity in Black, Caribbean, and African Communities, by repositioning Mental Health First Aid (MHFA) certification as one element of community mental health infrastructure rather than a stand-alone outcome. Although MHFA is widely used to improve mental health literacy, certification counts alone do not indicate whether community capacity, help-seeking pathways, or equitable access to care have meaningfully improved. 

Background: The purpose of this study is to test the effectiveness of physical therapy treatment for non-specific pelvic pain using Systemic Manual Therapy (SMT). This study evaluates outcomes across episode of care and after implementation of specific SMT protocols. Design: Computerized decision support software (CDSS) analysis of electronic medical records (EMR) using the Halili Physical Therapy Statistical Analysis Tool (HPTSAT) to query EMR.

Psychedelics a class of psychoactive compounds such as psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) are undergoing a scientific renaissance. Studies since 2020 have shown their therapeutic promise in mental health treatment. This Commentary synthesizes historical usage, current neuroscientific and clinical evidence, and explores ethical and regulatory frontiers for future medical integration.

Plasma donation is generally considered a safe procedure, and most reported adverse events are related to venipuncture or transient volume loss. Arterial thrombotic events, including acute myocardial infarction, are exceedingly rare but have been described after source plasma donation performed by plasmapheresis. 

Inflammatory processes are essential for tissue integrity in living systems as they ward off intruders such as parasites, microbes and viruses rendering them protective safeguards to control external threats. However, inflammation many times is accompanied by collateral tissue damage, and is thus followed by tightly orchestrated phases of recovery. Indeed, these mechanisms are not only operational in peripheral tissue, but also occur within the central nervous system (CNS).

Cervical disc herniation (CDH) can produce severe radiculopathy and functional impairment, and management becomes more complex when neurological comorbidities such as multiple sclerosis (MS) are present. This case study reports on a 35-year-old female with CDH at C5–C6 with a concurrent demyelinating MS lesion at the same level, who presented with debilitating cervical pain, marked left upper-extremity weakness (3/5 strength), sensory loss, absent reflexes, and significant activity limitations.

Down syndrome (DS), caused by trisomy 21, is the most frequent genetic cause of intellectual disability worldwide. Advances in medical care have markedly increased life expectancy, revealing a new clinical challenge: premature aging and a very high prevalence of Alzheimer’s disease (AD) in adulthood. Nearly all adults with DS develop cerebral amyloid pathology by midlife, largely due to overexpression of the amyloid precursor protein gene located on chromosome 21.

Earlier Am J Cardiol papers reported that a composite measure of marital quality predicted heart failure (HF) survival over follow-up intervals of 3 and 8 years after adjusting for baseline illness severity (NYHA class). 

Germ-cell tumors (GCT) are among the most curable solid malignancies, with approximately 70% of patients with advanced disease cured by frontline cisplatin-based standard-dose chemotherapy (SDC), with or without surgery [1]. However, outcomes are worse for patients whose tumors relapse or have refractory disease.

Glioblastoma (GBM) is characterized by profound immunosuppression and poor response to immunotherapy. Sex biased incidence and outcomes suggest that immune programs may be differentially regulated in males and females, but the molecular substrates of this divergence remain incompletely defined. TACSTD2 (TROP2), an epithelial lineage marker and therapeutic target in multiple solid tumors, is normally silent in the brain yet becomes aberrantly reactivated in a subset of GBM via promoter CpG hypomethylation with sex modulated prognostic effects. 

Towards an evolution of the therapeutic model in temporomandibular disorders (TMD) that can be expressed at the level of the temporomandibular joint or at a distance from it. Their management has long been based on a hierarchical model, commonly referred to as the "therapeutic gradient".

Subretinal drusenoid deposits (SDDs), a hallmark of age-related macular degeneration (AMD), have been linked to cardiovascular disease, but the underlying mechanism remains unclear. We investigated the association between SDDs and severe aortic stenosis (AS).

Current therapies for antibody-mediated autoimmune diseases largely rely on broad immunosuppression or lineage-wide B-cell depletion. These approaches are associated with increased risks of infection and other adverse effects. This commentary focuses on Chimeric Autoantibody Receptor (CAAR) T-cell technology as a precision immunotherapy that selectively eliminates pathogenic autoreactive B-cell clones while preserving protective immunity.

Nimesulide, a preferential Cyclooxygenase-2 (COX-2) inhibitor, is frequently prescribed for musculoskeletal conditions in middle-aged (45–64 years) and older adults (≥65 years). Given age-associated alterations in drug metabolism, polypharmacy, and comorbidities, its safety and efficacy in adults >45 years warrants critical re-evaluation.

The recently published review by Baeten et al. outlines the scientific and translational evidence supporting the role of cyclin dependent kinase (CDK) 4/6 in rheumatoid arthritis (RA) pathology, and it discusses how this stromal (synovial fibroblast) target provides the basis for a drug class with a novel non-immunosuppressive mechanism of action that could change the current immunosuppressive treatment paradigm in RA.

The nuclear envelope (NE) is the hallmark of eukaryotic cells, serving as a critical physical barrier that compartmentalizes the genome and separates nuclear and cytoplasmic processes to tightly regulate nucleocytoplasmic transport. Biomolecular phase separation, a physicochemical process frequently driven by proteins containing intrinsically disordered regions (IDRs), is a fundamental mechanism governing diverse cellular activities.

Cell signaling is a complex, interconnected system that controls vital cellular processes such as proliferation, post-translational modifications (PTMs), and, ultimately, cell fate, controlling protein degradation and apoptosis. Alterations in these pathways can lead dysregulation.

Aneurysmal bone cyst (ABC) is a benign but locally aggressive bone lesion. USP6 gene rearrangements have been proposed as a key diagnostic marker, detectable via fluorescence in situ hybridization (FISH). However, its clinical utility and correlation with recurrence remains unclear. This study evaluates USP6 FISH as a diagnostic tool and investigates whether USP6 positivity is associated with an increased recurrence risk. This retrospective study analyzed 87 patients with primary ABC at Klinikum rechts der Isar, Technical University of Munich (1991–2021).

This study investigated clinical inertia in the management of type 2 diabetes mellitus (T2DM), a major challenge in clinical practice. The primary aim was to assess the delay in therapeutic intensification among patients with persistently elevated hemoglobin A1c (HbA1c) levels (>8.0%) who were already receiving two oral antidiabetic drugs, considering the availability of newer effective therapies. We conducted a retrospective cohort study using data from the Clalit Health Service database in Israel.