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Commentary on Studies Citing This Author Concerning Doodling as a Measure of Burnout
The ability of doodling to act as an indicator of depression and anxiety regarding research burnout is a topic that has seen the publication of six articles by this author since 2021. This commentary aims to determine the extent to which any of these articles have been cited by subsequent researchers in furthering the literature on doodling. The keywords “C Nash Doodling Burnout” were searched through Google Scholar in February 2024 with 142 returns.
HIV/AIDS Care and Support Services Satisfaction for Orphan and Vulnerable Children in Northwest Ethiopia: Mixed Method Study
Background: The provision of comprehensive care and support services to orphans and disadvantaged children that are individualized and tailored through the use of child- and family-centered information is critical but little if any information is available on satisfaction with HIV/AIDS care among orphans and vulnerable children in Gondar. Therefore, this study aimed to assess the satisfaction of HIV/AIDS care and support service delivered to caregivers of Orphans and Vulnerable Children, Gondar City, 2023.
Magnitude of HIV Index Case Testing among HIV Positive Clients Attending ART Clinic in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2023
Background: Index case testing is the provision of HIV testing services to family members or sexual partners of individuals already diagnosed with HIV. Its promotion stems from its potential to detect new cases, improve testing coverage, enhance ART retention, and provide convenience to affected families. Although evidence on index case testing in Ethiopia, particularly in the study area, is lacking, even, it is regarded as a crucial strategy for reducing HIV transmission among those unaware of their HIV status.
Bending the Curve Through Innovations to Overcome Persistent Obstacles in HIV Prevention and Treatment
Background: HIV/AIDS remains a major global public health challenge despite significant progress in treatment. New infections and HIV-related deaths persist, fueled by disparities in prevention and care access. Purpose: This review synthesizes recent advances across key domains - from vaccine development to novel treatments to omics approaches – that collectively hold promise for ending the HIV/AIDS pandemic.
The Role of Transcranial-Color-Doppler in the Management of Basilar Artery Stenosis: Case Series and Systematic Review of Literature
Managing vertebrobasilar (VB) stroke, particularly basilar artery occlusion (BAO), presents challenges due to diverse clinical presentations and intricate diagnostics, risking delays in acute-phase reperfusion therapies. The diagnostic complexities of VB stroke prompt questions about whether presentation tempo influences outcomes. For non-urgent cases of basilar artery stenosis (BAS) lacking guidelines, clinical management becomes case-dependent.
Essentials of CAR-T Therapy and Associated Microbial Challenges in Long Run Immunotherapy
Chimeric antigen receptor (CAR)-T cell therapy has shown potential in improving outcomes for individuals with hematological malignancies. However, achieving long-term full remission for blood cancer remains challenging due to severe life-threatening toxicities such as limited anti-tumor efficacy, antigen escape, trafficking restrictions, and limited tumor invasion. Furthermore, the interactions between CAR-T cells and their host tumor microenvironments have a significant impact on CAR-T function.
Mechanism, Challenges, and Progresses of Chimeric Antigen Receptors T-cell Cancer Therapy
Cancer is a deadly disease and affects everyone at any level of age. Many people lose hope once they are diagnosed with cancer. This is because there is no effective treatment for it. Till the end of the 19th century, researchers across the world were eager to design effective remedies for this decapitating phenomenon and designed so many interventions even though nothing is compensatory for a malignant tumor; in some cases, the side effects overwhelm the benefits.
Comprehensive Network and Structural Analysis of Bovine Papillomavirus, Squamous Cell Carcinoma Markers, and Elucidation of Efficacy Mechanisms of Phytochemicals from Thuja Occidentalis
Papillomaviruses infect cutaneous tissue in various species including bovines and from benign warts to malignant squamous cell carcinoma causing severe economic losses to the farmers. The mechanisms by which bovine papillomaviruses interact with host tissue are unclear. Hence in this study using classical network analysis tools, we evaluated interactions of Bovine papilloma (BPV) variants, with markers and receptors implicated in squamous cell carcinoma.
The Domino Effect of Polypharmacy. A Dangerous Catalyst That Starts Numerous Bio-Psycho-Social Chain Reactions
Increasing medicalization causes some disconcerting trends in medical decision making. Polypharmacy is one of its most important consequences. The tendency to equate the concepts of risk factor and disease, the changes in the biomedical assessment of the severity of many health problems, and the increase in the number of pharmacological treatments create a growing set of multimorbidity and polypharmacy, and this produces a dramatic domino effect
POSTCOVID-19 WAR Era, Abnormally Some Patients being Affected by Exceptional Disease Progression, and Accelerated Excessive Mortality Rate
From 2019, POSTCOVID-19 pandemic attacks, human beings were under pandemic-attacked condition that caused by different industrial modern diseases, and being confronted with unusual disease progression, which increased abnormal excess mortality and morbidity rates. The exact mechanism of action is not completely elucidated yet. What is (un)known?
Enhancing the Efficacy of CAR-T Cell Therapy: A Comprehensive Exploration of Cellular Strategies and Molecular Dynamics
The emergence of chimeric antigen receptor T cell (CAR-T cell) therapy has revolutionized cancer treatment, particularly for hematologic malignancies. This commentary discusses developments in CAR-T cell therapy, focusing on the molecular mechanisms governing T cell fate and differentiation. Transcriptional and epigenetic factors play a pivotal role in determining the specificity, effectiveness, and durability of CAR-T cell therapy.
Understanding Anxiety
This study is the first of its kind to diachronically analyze how the use of language surrounding anxiety has changed in each version of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Using corpus linguistic technology, the collocations of the word “anxiety” were analyzed and ranked using log dice to determine the strength of associations both within and across each version of this clinical guide.
Teaching an Old Drug a New Trick: Targeting Treatment Resistance in Genitourinary Cancers
In the quest for improving the clinical outcome of patients with metastatic genitourinary cancers, including metastatic renal cell carcinoma (mRCC), the emphasis often is on finding new targeted therapies. However, two studies by Jordan et al. (Oncogenesis 2020) and Wang et al. (Cancer Cell Int 2022) demonstrate the feasibility of improving the efficacy of a modestly effective drug Sorafenib against mRCC by attacking a mechanism hijacked by RCC cells for inactivating Sorafenib.
Commentary on “Review on Nanocrystalline Silicon Thin Films for Heterojunction Solar Cells”
The article presents a commentary for the recent publication on nanocrytalline silicon thin films for heterojunction solar (SHJ) cells. The aim of the communication is to highlight some of the important mechanism discussed in the report for improved structure and interface properties which results in better device fill factor and hence enhanced efficiency. Furthermore, the discussion has been extended to present some of the recent literatures which have followed the similar guidelines for material synthesis with improved optical gain in applications of SHJ solar cells.
Thrombosis Attack in a Cancer Patient: A Case Report
Background: Cancer is the second leading cause of mortality after cardiovascular disease. The second common leading cause of mortality in cancer patients is thrombosis, vary from arterial or venous thromboembolism to disseminated intravascular coagulation.
Mitral Valve Culture Negative Endocarditis Complicated by Severe Mitral Regurgitation and Chordae Tendinea Rupture
Infective endocarditis has a high mortality rate. Criterion for diagnosis is a positive blood culture, however, some cases present with negative blood culture. We present a 65-year-old male complaining of palpitations. EKG showed atrial fibrillation with RVR. Transthoracic echocardiogram showed severe mitral regurgitation and possible vegetation. Transesophageal echocardiogram revealed endocarditis with ruptured chordae and vegetation on the posterior leaflet.
Treatment of Traumatic Brain Injury: Nanotherapeutics
Nanotechnology and regenerative nanotherapeutics enrich the renewing features and function of the diseased cells and tissue by replenishing the local environment, while inhibiting further degeneration. These featured therapeutics perform cell maintenance and promote cellular events to develop better communication between re-forming molecules of remedies and the brain.
Homeostatic Synaptic Plasticity may be Targeted for the Prevention of Post-Stroke Epilepsy
Stroke is the most common cause of acquired epilepsy, with up to 30 percent of stroke survivors developing epilepsy over time. However, the mechanisms leading to neuronal hyperexcitability and epilepsy in stroke survivors are not fully understood. In a recently published work, we demonstrate that ischemic stroke induces homeostatic plasticity regulation in the surviving neurons in the peri-stroke area.
Personalized Neoantigen DNA Cancer Vaccines: Current Status and Future Perspectives
Tumor mutation-derived neoantigens are considered promising targets for cancer immunotherapy. Personalized vaccines have emerged as an approach to deliver neoantigens and thereby trigger the induction of specific T-cell responses that can find and eliminate tumor cells based on the cell-surface presence of neoantigens. To this end, several neoantigen vaccine formats have provided encouraging results in clinical trials, resulting in neoantigen immunogenicity and clinical benefit.
Changes in Obesity Prevalence Following Spinal Cord Injury: A Retrospective Review of Body Mass Index
Background: The prevalence of obesity is high in individuals with spinal cord injury (SCI) due to the alterations in body composition that occur as a direct result of injury. Body mass index (BMI) is used to classify body habitus. In 2009, an adjusted BMI classification, with lower thresholds for obesity, was recommended for individuals with SCI. Objective: Determine obesity prevalence before and after SCI to examine the trajectory of obesity development.
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