Articles

Periodontitis and inflammatory bowel disease (IBD) are chronic inflammatory conditions driven by dysbiotic microbial communities that subvert host mucosal immunity. Central to the immunopathology of both diseases is the disruption of the balance between regulatory T cells (Tregs) and T helper 17 (Th17) cells, an equilibrium that governs tissue homeostasis versus inflammatory destruction. Polyamines, principally putrescine (PUT), spermidine (SPD), and spermine (SPN), are emerging as critical immunometabolic regulators that modulate the plasticity and functional identity of both cell populations.

POEMS syndrome is a rare paraneoplastic multisystemic disorder caused by an underlying monoclonal plasma-cell dyscrasia and characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes. Because early manifestations often overlap with other conditions such as chronic inflammatory demyelinating polyneuropathy (CIDP) and multiple myeloma, diagnosis is frequently delayed.

Antibody–drug conjugates (ADCs), which merge the specificity of monoclonal antibodies with potent cytotoxic payloads, are becoming more common as a therapeutic option for cancer patients with multiple approvals and many more in clinical development [1,2]. As of March 2026, 15 ADCs have been approved by the FDA for use in oncological indications (Table 1), and despite their targeted design, ocular adverse events (OAEs) have emerged as adverse events of special interest in patients across various tumor types [3,4].

The purpose of this study was to explore knowledge, practices, facilitators and barriers of healthy eating among White, Hispanic, and Black individuals with Type 2 Diabetes Mellitus (T2DM). A qualitative content analysis was conducted using data from four focus groups. Participants were recruited from a hospital registry who self-reported successful dietary behaviors. Adults with T2DM were recruited across different racial and ethnic groups, and focus groups were facilitated using a structured guide.

Background: Advances in urologic management have improved survival among individuals with Spina Bifida (SB), making successful transition from pediatric to adult care increasingly important. However, transition remains challenging due to complex medical needs, functional limitations, and healthcare system barriers. We sought to compare patient, caregiver, and provider perspectives on successful transition and identify priorities for improvement.

The scope of the Archives of Biomedical Research encompasses the burgeoning integration of multidisciplinary fields of medical and biological science and the translation from research into practice.
An area within the scope of neuroscience and behaviour science deserving significant attention is that of the role of the chemical and haptic senses in wellbeing and their impact on quality of life with declines occurring in ageing.

Up to 40% of adult individuals with Cystic Fibrosis (CF) develop a condition known as Cystic Fibrosis Diabetes (CFRD). This co morbid condition, is secondary to insulin deficiency as a result of pancreatic islet cell damage subsequent to the underlying genetic mutation in CF. CFRD is associated with the development of microvascular complications however, little is known about the prevalence of neuropathic dysfunction in the form of cardiac autonomic neuropathy (CAN).

Pancreaticobiliary maljunction, an abnormal junction between pancreatic and Common Bile Duct (CBD) which forms before the opening in duodenum to form a long common channel, with or without biliary dilatation is a rare cause of recurrent pancreatitis in children. The anomalous junction results in reflux of pancreatic juices into the biliary tract leading to injury.

Discovered in 1981, Quantum Dots (QDs) are semiconductor nanocrystals defined by quantum confinement, which allows for precise sizetuneable optoelectronic properties. Their brightness, photostability, and discrete energy levels have revolutionized fields from energy storage to optoelectronics.

Deciding on intrauterine device selection requires consideration of multiple factors beyond contraceptive efficacy. Device frame dimensions relative to uterine cavity size, differences in bleeding and pain profiles between copper and levonorgestrel-releasing devices, rates of mechanical complications, and patient-specific anatomic factors are not often adequately addressed during contraceptive counseling despite their influence on device tolerance and continuation. 

Lower limb injuries in athletes frequently arise from poor movement mechanics and neuromuscular control, underscoring the importance of early identification of biomechanical deficiencies to prevent injury. The Landing Error Scoring System (LESS) and the Modified Tuck Jump Assessment (MTJA) are established screening tools: LESS assesses landing mechanics, while MTJA evaluates neuromuscular control during repeated jumps.

The increasing exposure of children and adolescents to global crises and digitally mediated distressing news represents a growing challenge to mental health. Psychological research indicates rising levels of anxiety, emotional overload, helplessness, and withdrawal, while educational and preventive responses often remain predominantly cognitive. This article argues that emotional learning, conceptualized as a dimension of interdisciplinary framed Lebenskunstbildung (education for the art of living), constitutes a crucial resource for mental health promotion. 

Microplastics are everywhere. Studies detect concentrations up to 1000 particles/L in seawater and up to 10 particles/cm³ in the atmosphere. Humans can be exposed to more than 48,000 microplastic particles/day through inhalation alone. These tiny fragments-smaller than 5 mm–are now in human blood, lungs, placentas, and breast milk.Our recent review termed microplastics the "hidden poison"–a phrase reflecting a troubling reality we create daily yet fail to see. 

The ancient medicinal system of Ayurveda highlights the role of diet in remaining healthy and disease-free. Plants form the essential diet in Indian households, and much emphasis is laid on eating proper food at the right time interval. In recent research conducted it was found that many of the plant species widely used as vegetables in Indian cuisines are also used medicinally for the treatment of various diseases. The phytochemicals present in plants are mainly responsible for the beneficial and curative actions. Globally, among the blood-related disorders most commonly encountered is anemia, i.e., a reduction in blood cells due to various reasons. It can also be indicative of any other underlying disease in a person, which seems to be diagnosed with great difficulty. It usually occurs due to chronic blood loss, malignancy, infection, increased hemolysis, endocrine disorders, bone marrow disorders and some other diseases. 

Chronic interpersonal abuse in workplace settings may generate trauma-spectrum symptoms that present in acute or crisis contexts. However, such cases are often described using lay terminology and may remain under-recognized in emergency and trauma medicine. This report examines a case of chronic workplace interpersonal trauma conceptualized within trauma-informed frameworks of coercive control and prolonged relational stress.

Cardiac CT angiography (CCTA) has become a mainstream and integral part of many cardiology practices based on a vast base of literature supporting and validating its clinical utility. It is now recommended as a first-line test for the evaluation of chest pain according to the American Heart Association (AHA) and the American College of Cardiology (ACC). As the technology continues to advance, coronary imaging has improved in stride. 

Human Papilloma Virus (HPV)-related cervical cancer (CC) still drives cancer-related mortality in low-to-middle income countries (LMICs), exacerbated by disparities in HPV screening, HPV vaccination status, specialist availability, and treatment costs compared to higher-income countries. This study describes how botanical nutraceuticals may provide a viable, low-cost strategy to target molecular hallmarks of HPV-related CC that would specifically benefit regions with limited access to specialized oncologists or radiotherapy infrastructure.

HFpEF accounts for approximately half of all heart failure cases, and its prevalence is rising with the aging population. Unlike HFrEF, which is defined by reduced systolic function, HFpEF is diagnosed clinically: patients must have heart failure symptoms (exertional dyspnea, edema, orthopnea), preserved ejection fraction (EF) ≥ 50% and evidence of elevated LV filling pressures via echocardiography, natriuretic peptides, or invasive hemodynamics. 

This commentary applies a mental health and wellbeing lens to the recently published study report ‘Empowering Women to Cycle: Insights Beyond Numbers’ which explores the social, cultural and infrastructural barriers that currently discourage women in Ireland from choosing to cycle more. The benefits that cycling can have on women’s mental health and wellbeing are discussed, along with what is required to create a supportive framework that can empower more women in Ireland to cycle.

Artificial Intelligence (AI) as recently emerged as a pervasive element of academic research globally. Such an integration has revolutionized higher education worldwide. This transformation, however, has come with significant disparities in awareness, access, and ethical preparedness across developing contexts, particularly highlighting the challenges faced by institutions in Ghana where many stakeholders lack the necessary training and resources to effectively integrate AI into their academic practices.