Commentary Open Access
Volume 2 | Issue 1 | DOI: https://doi.org/10.33696/immunology.2.016

CAR-T cell Goes on a Mathematical Model

  • 1University of São Paulo, Hospital das Clínicas (FMUSP) São Paulo, Brazil
  • 2National Laboratory for Scientific Computation,Brazil
+ Affiliations - Affiliations

Corresponding Author

Luciana Rodrigues Carvalho Barros, lucianalpt@gmail.com

Received Date: December 30, 2019

Accepted Date: February 06, 2020


CAR-T cell immunotherapy is a great advance in hematological cancers treatment. New CARs and therapy schemes are being developed and a mathematical model could contribute to a rational design of treatment. Here we comment and show new results with previously published models of CAR-T cell therapy, emphasizing the contribution of initial tumor load, the proliferation of CAR-T cell and inhibition of CAR-T cell activity by the tumor resulting in different scenarios as tumor escape, equilibrium (stable disease) and tumor elimination.


CAR-T cell, Immunotherapy, Mathematical model

Author Information X