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Journal of Cellular Immunology

ISSN: 2689-2812

Commentary Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/immunology.2.033

Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis

Malik Bisserier1, Lahouaria Hadri1,*
  • 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
+ Affiliations - Affiliations

Corresponding Author

Lahouaria Hadri, Lahouaria.hadri@mssm.edu

Received Date: April 20, 2020

Accepted Date: May 06, 2020

Citation:

Bisserier M, Hadri L. Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin- Induced Pulmonary Fibrosis. J Cell Immunol. 2020; 2(4): 149-156.


Copyright: © 2020 Bisserier M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by an accumulation of scar tissue within the lungs and the common presence of usual interstitial pneumonia. Unfortunately, only a few FDA-approved therapeutic options are currently available for the treatment of IPF and IPF remains associated with poor prognosis. Therefore, the identification of new pharmacological targets and strategies are critical for the treatment of IPF. This commentary aims to further discuss the role of sarcoplasmic reticulum Ca2+-ATPase 2a and its downstream signaling in IPF. Finally, this commentary offers new insights and perspectives regarding the therapeutic potential of AAV-mediated SERCA2A gene therapy as an emerging therapy for respiratory diseases.

Keywords

SERCA2a; Lung Fibrosis; AAV1; Gene Therapy

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