Loading
Journal of Cellular Signaling
ISSN: 2692-0638
Redox Homeostasis in Well-differentiated Primary Human Nasal Epithelial Cells
Oxidative stress (OS) in the airway epithelium is associated with inflammation, cell damage, and mitochondrial dysfunction that may initiate or worsen respiratory disease. Redox regulation maintains the equilibrium of pro-oxidant/antioxidant reactions but can be disturbed by environmental exposures. The mechanism(s) underlying the induction and impact of OS on airway epithelium and how these influences on respiratory disease is poorly understood.
J Cell Signal, 2022, Volume 3, Issue 4, p193-206 | DOI: 10.33696/Signaling.3.083Resveratrol and Astaxanthin Protect Primary Human Nasal Epithelial Cells Cultured at an Air-liquid Interface from an Acute Oxidant Exposure
Oxidative stress (OS) in the airway epithelium is associated with cell damage, inflammation, and mitochondrial dysfunction that may initiate or worsen respiratory disease. However, it is unclear whether exogenous antioxidants can provide protection to the airway epithelium from OS. Resveratrol and astaxanthin are nutritional compounds that have shown diverse benefits including protection against OS and inflammation in various situations.
J Cell Signal, 2022, Volume 3, Issue 4, p207-217 | DOI: 10.33696/Signaling.3.084c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease
Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most common form, afflicting approximately 1 in 1,000 people and is caused by mutations in the transmembrane proteins polycystin-1 (Pkd1) and polycystin-2 (Pkd2).
J Cell Signal, 2022, Volume 3, Issue 1, p62-78 | DOI: 10.33696/Signaling.3.068The Outcome of Tumor Ablation Therapies is Determined by Stress Signaling Networks
Increasingly prominent roles in interventional oncology are held by various tumor ablation therapies performed by direct applications of local acute trauma-inducing insult to the targeted lesion aiming for its rapid in situ destruction. These therapies include treatments based on various forms of thermal energy delivery (photothermal, cryoablation, microwave ablation, radiofrequency ablation), non-thermal illumination (photodynamic therapy), electric field exposure, or high hydrostatic pressure
J Cell Signal, 2022, Volume 3, Issue 1, p1-4 | DOI: 10.33696/Signaling.3.062Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver Disease
Hepatocellular carcinoma (HCC) is a significant cause of cancer mortality worldwide. Chronic hepatic inflammation and fibrosis play a critical role in the development of HCC. Liver fibrosis develops as a result of response to injury such that a persistent and excessive wound healing response induces extracellular matrix (ECM) deposition leading to HCC.
J Cell Signal, 2021, Volume 2, Issue 3, p221-227 | DOI: 10.33696/Signaling.2.054Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators
Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules 33-11 and KH-4-43 that inhibit E3 CRL4’s core ligase complex and exhibit anticancer potential.
J Cell Signal, 2021, Volume 2, Issue 3, p195-205 | DOI: 10.33696/Signaling.2.051NH2-Terminal Cleavage of Cardiac Troponin I Signals Adaptive Response to Cardiac Stressors
Cardiac sarcomeres express a variant of troponin I (cTnI) that contains a unique N-terminal extension of ~30 amino acids with regulatory phosphorylation sites. The extension is important in the control of myofilament response to Ca2+, which contributes to the neuro-humoral regulation of the dynamics of cardiac contraction and relaxation.
J Cell Signal, 2021, Volume 2, Issue 3, p162-171 | DOI: 10.33696/Signaling.2.048APE1/Ref-1 – One Target with Multiple Indications: Emerging Aspects and New Directions
In the realm of DNA repair, base excision repair (BER) protein, APE1/Ref-1 (Apurinic/Apyrimidinic Endonuclease 1/Redox Effector - 1, also called APE1) has been studied for decades. However, over the past decade, APE1 has been established as a key player in reduction-oxidation (redox) signaling. In the review by Caston et al. (The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease), multiple roles of APE1 in cancer and other diseases are summarized.
J Cell Signal, 2021, Volume 2, Issue 3, p151-161 | DOI: 10.33696/Signaling.2.047Phosphorylation of RIAM Activates Its Adaptor Function in Mediating Integrin Signaling
Extracellular matrix (ECM) surrounding cells in solid tissue provides mechanical support and communicates with cells through cell adhesion molecules (CAMs) at the cell surface. Integrin is a major group of CAMs represented by a family of αβ heterodimeric single transmembrane receptors.
J Cell Signal, 2021, Volume 2, Issue 2, p103-110 | DOI: 10.33696/Signaling.2.041Effects of a CB2 Subtype Selective Agonist ABK5-1 on Cytokine Production in Microglia
Neuroinflammation is closely associated with various diseases including neuropathic pain. Microglia are immune cells in the central nervous system which are the main players of immunity and inflammation. Since microglia are activated by nerve injury, and they produce proinflammatory mediators to cause neuropathic pain, targeting activated microglia is considered to be a strategy for treating neuropathic pain.
J Cell Signal, 2021, Volume 2, Issue 2, p85-93 | DOI: 10.33696/Signaling.2.038Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease
The Wnt signaling is classified as two distinct pathways of canonical Wnt/β-catenin signaling, and the non-canonical pathways of planar cell polarity and Wnt/Ca2+ pathways. However, the scientific discoveries in recent years have shown that canonical and noncanonical Wnts pathways are intertwined and have complex interaction with other major signaling pathways such as hedgehog, Hippo and TOR signaling.
J Cell Signal, 2021, Volume 2, Issue 1, p52-62 | DOI: 10.33696/Signaling.2.035Possible Therapeutic Use of Natural Compounds Against COVID-19
The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to coronavirus disease-19 (COVID-19); a pandemic disease that has resulted in devastating social, economic, morbidity and mortality burdens. SARS-CoV-2 infects cells following receptor-mediated endocytosis and priming by cellular proteases.
J Cell Signal, 2021, Volume 2, Issue 1, p63-79 | DOI: 10.33696/Signaling.2.036S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages
Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P).
J Cell Signal, 2021, Volume 2, Issue 1, p47-51 | DOI: 10.33696/Signaling.2.034FOXP1 Interacts with MyoD to Repress its Transcription and Myoblast Conversion
Forkhead transcription factors (TFs) often dimerize outside their extensive family, whereas bHLH transcription factors typically dimerize with E12/E47. Based on structural similarities, we predicted that a member of the former, Forkhead Box P1 (FOXP1), might heterodimerize with a member of the latter, MYOD1 (MyoD).
J Cell Signal, 2021, Volume 2, Issue 1, p9-26 | DOI: 10.33696/Signaling.2.032Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1
Obesity has reached a global epidemic and it predisposes to the development of insulin resistance, type 2 diabetes and related metabolic diseases. Current interventions against obesity and/or type 2 diabetes such as calorie restriction, exercise, genetic manipulations or established pharmacological treatments have not been successful for many patients with obesity and/or type 2 diabetes.
J Cell Signal, 2020, Volume 1, Issue 4, p160-168 | DOI: 10.33696/Signaling.1.025Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics
Nausea and vomiting are protective defense mechanisms by which vomit competent species avoid ingestion of potentially toxic substances. More specifically, vomiting is the act of forceful expulsion of gastrointestinal contents through the mouth, whereas nausea is an unpleasant painless subjective feeling that one will imminently vomit.
J Cell Signal, 2020, Volume 1, Issue 4, p155-159 | DOI: 10.33696/Signaling.1.024Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS
Being a sophisticated and highly organized living system, mammals harbor a large number of biomolecular machineries which represent a dynamic and complex network of interconnections responsible for the effective operation, development and survivability of their body cells. Sphingolipids are a special class of lipids in eukaryotic cells, which have recently gained the attention of researchers because of their involvement in several fundamental processes of living cells, including proliferation
J Cell Signal, 2020, Volume 1, Issue 3, p56-69 | DOI: 10.33696/Signaling.1.013The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors
Glucocorticoids (GCs) are defined by their role in maintaining glucose homeostasis and natural GCs are a class of corticosteroids secreted by the adrenal cortex. Cortisol is the most important natural GC in humans. Cellular cortisol levels are regulated by the tissue-specific metabolic enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD 1 and 2); 11β-HSD 1 converts inactive cortisone to active cortisol, while 11β-HSD 2 has the opposite function.
J Cell Signal, 2020, Volume 1, Issue 3, p42-49 | DOI: 10.33696/Signaling.1.011Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies
Observational studies have demonstrated association of metformin with reduced cancer incidence and mortality in multiple cancer types, including gastrointestinal (GI) malignancies. Anti-neoplastic effects of metformin are believed through many mechanisms including activation of AMP-activated protein kinase, which controls mammalian target of rapamycin (mTOR) growth regulatory pathway.
J Cell Signal, 2020, Volume 1, Issue 2, p35-41 | DOI: 10.33696/Signaling.1.008Emerging Role of TRPML1 Mucolipin Endolysosomal Channel in Cancer
The transient receptor potential mucolipin 1 (TRPML1) is an endolysosomal channel belonging to the TRP family. Clinically, mutations of TRPML1 have been responsible for a severe lysosomal storage disorder called mucolipidosis type IV.
J Cell Signal, 2020, Volume 1, Issue 1, p4-7 | DOI: 10.33696/Signaling.1.002Manipulating Oxidative Stress Following Ionizing Radiation
It is now well accepted that the ionizing radiation-generated reactive oxygen species (ROS), that constitute ~2/3 of the effects of external beam radiation, do not only produce direct tumor cell death, but also affect the surrounding microenvironment. Moreover, this indirect effect of radiation may result in systemic effects, specifically the initiation of an inflammatory response.
J Cell Signal, 2020, Volume 1, Issue 1, p8-13 | DOI: 10.33696/Signaling.1.003Flow Cytometric Characterization of Accidental Cell Death Highlights Connections to Regulated Cell Death
Damage-Associated Molecular Patterns (DAMPs) are known by their nature to cause inflammatory responses in numerous disease states from cancer, trauma to age related diseases (e.g. atherosclerosis, Alzheimer’s and Parkinson’s diseases), these molecules are released by cells undergoing cell death.
J Cell Signal, 2020, Volume 1, Issue 1, p1-3 | DOI: 10.33696/Signaling.1.001Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.