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Oxidative Stress and Metabolic Disorders
Oxido-reductive imbalance causes cellular stress in terms of macromolecular damage leading to altered molecular signaling which ultimately becomes an essential factor in the development of a disease. Failure of the cellular antioxidative system and excessive ROS generation not only damages proteins and lipids but also modulates energy metabolism, cell cycle control, genetic mutations, inflammation, and cellular transport mechanisms. Several metabolic stress like high glucose, high fat diet, alcohol consumption, etc. may cause high oxidative stress. On the contrary, recent research has established a strong connection between oxidative stress and metabolic disorders like diabetes, obesity, and cancer. Studying the role of Oxidative stress in the etiology of metabolic disorders will not only help in understanding the pathophysiology of the disease but also enable the identification of novel therapeutic avenues for treatment.
Vivek Kumar Pandey, Himanshu Pawankumar Gupta