Integrins are cellular receptors that regulate cell adhesion and many other cellular functions. Integrins can be activated via an “insideout pathway” that is promoted by RAP1 GTPase. RAP1-GTP-Interacting Adaptor Molecular (RIAM) mediates integrin activation by linking RAP1 GTPase to talin, an integrin activator. RIAM’s function in integrin signaling is tightly regulated. In this commentary, we review recent studies of the molecular mechanisms underlying RIAM autoinhibition via both intramolecular interaction and oligomer assembly, and the phosphorylation-dependent activation of RIAM.
RIAM, Integrin, Phosphorylation, RAP1, FAK, SRC, Lamellipodin