Nowadays, people pay more and more attention to homeostatic regulation, which is the detrimental effect of stress on physiological and psychological well-being and cannot be ignored. The public perception of anxiety has been associated with the hypothalamic hormones, because of the pivotal role of the hypothalamic-pituitaryadrenal axis to promote the pituitary-adrenal functions and endocrine responses.

COVID-19, a global pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) has resulted in hospitalization in many cases.

The insulin-like peptides family is composed of insulin, insulin-like growth factor 1 (IGF1), and insulin-like growth factor (IGF2), together with IGF binding proteins (IGFBP1- IGFBP6) [1]. IGF2 is a single-chain secreted protein of 67 amino acids with important functions in fetal growth and development. IGF2 is the less characterized member of this family, and in mice and rats its expression in the brain occurs during embryonic development and adulthood but declines during aging [2].

Narrative development is fundamental to human mental health. Interventions providing individuals with the means to construct and recall robust and effective narratives are necessary in promoting positive mental health outcomes. The primary embodied location of personal narrative development is the hippocampus. Recent advances regarding the relationship among the hippocampus, narrative, and mental health are thus relevant concerning the hippocampal mechanisms that simultaneously function to map environmental position and to generate episodic memories.