Mini Review Open Access
Volume 1 | Issue 3 | DOI: https://doi.org/10.33696/Signaling.1.011

The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven CT 06520, USA
  • 2Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven CT 06520, USA
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Corresponding Author

Julie E. Goodwin, Julie.goodwin@yale.edu

Received Date: June 04, 2020

Accepted Date: June 15, 2020


Glucocorticoids are steroid hormones produced by the adrenal cortex in a circadian manner and they participate in many physiological and pathological processes. Synthetic glucocorticoids have been universally applied to treat inflammatory diseases and immune disorders. Due to their angiostatic property, glucocorticoids are often added to regimens for cancer treatment. In the current review, we summarize how glucocorticoids influence angiogenesis in common solid tumors based on literature from the last ten years. Usage of glucocorticoids can be a double-edged sword in the treatment of some malignancies. There are still unanswered questions about the role of glucocorticoids in the treatment regimens of some common cancers. Therefore, we suggest prudent and restricted administration of glucocorticoids to treat solid tumors.


Glucocorticoids, Angiogenesis, Malignancy

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