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2022

Volume 3, Issue 3, p63-81

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).

J Exp Neurol, 2022, Volume 3, Issue 3, p63-70 | DOI: 10.33696/Neurol.3.064

Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine

Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury.

J Exp Neurol, 2022, Volume 3, Issue 3, p71-74

The Jalisco Mutation: Familiar Alzheimer’s Disease in México

Before the age of 65, people with mutations in the genes for Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and the amyloid precursor protein (APP) experience familial Alzheimer’s disease (FAD). The sporadic type of Alzheimer’s disease (AD) is multifactorial and associated with the Apolipoprotein E ε4 allele (APOE ε4), which can up to 12 times increase the risk of getting the condition

J Exp Neurol, 2022, Volume 3, Issue 3, p75-77

An Updated Overview of Alzheimer’s Disease

Alzheimer’s Disease (AD) is the most common form of dementia. Patients diagnosed with AD experience disordered cognition and memory, as well as changes in behaviour and personality. The vast majority of AD is diagnosed in patients aged over 65 years and classified as late onset (LOAD), with the remaining ~1% of cases termed early onset AD (EOAD).

J Exp Neurol, 2022, Volume 3, Issue 3, p78-81

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Prevention of Suicide in Persons with Progressive Neurological Diseases

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Epilepsy in Neurodegenerative Disease: A Commentary

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To Stick or Not to Stick? Scalp and Intracranial EEG Evaluation Both Help Achieve Good Surgical and Neuropsychiatric Outcomes in Epilepsy Surgery up to 20 Years Post-Surgery

Epilepsy has a worldwide prevalence of about 50 million [1]. Seizure medications provide adequate control in two thirds of these patients but about a third are refractory to multiple medications and need surgery or other treatments [2].

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The annual incidence of aneurysmal subarachnoid hemorrhage (SAH) in the United States is 6-16 cases per 100,000 population, with approximately 30,000 cases occurring each year.

Treatment of Neurological Manifestations of Mucopolysaccharidoses: Translational Considerations in Drug Development

Since the development of Ceredase® and Cerezyme® for the treatment of Gaucher disease in the early 1990s, treatment of lysosomal storage disorders via enzyme replacement therapy (ERT) has provided life-changing benefit to patients and their families.

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Microptofluidic Technology for Biodiagnostics of Traumatic Brain Injury: A Commentary

Traumatic brain injury (TBI) is a leading cause of death and neurological disability worldwide with millions of people sustaining and living with its long-term effects []. TBI is often categorized as mild, moderate and severe with primary injuries separated as either focal or diffuse, with the latter including contusions, intracranial hematomas and brain herniation. 

Alzheimers Disease: A Brief Review

The worldwide prevalence of dementia is estimated to be over 45 million people. Alzheimer’s disease (AD) is the most common cause of dementia, responsible for 60-80% of cases. 

Effect of Exosomes on Alzheimer’s Disease

AD is a neurodegenerative disease characterized by progressive cognitive impairment, behavioral changes, memory loss and executive dysfunction, all of which present serious threats to the health of older people.

Neurocysticercosis: Autoantibodies, Another Cog in the Wheel of Its Variable Pathogenicity

Neurological diseases are a major cause of disability and the second cause of death today. This reality has stimulated the search for predictive biomarkers facilitating early diagnosis and the design of appropriate treatments.

Comment On: Modulatory Effects of Magnetic Vestibular Stimulation on Resting-State Networks Can be Explained by Subject-Specific Orientation of Inner Ear Anatomy in the MR Static Magnetic Field

It was recently demonstrated that modulations in resting-state networks (RSNs) can be introduced via the stimulation of the vestibular inner ear by a strong magnetic field (>1 tesla) as used in magnetic resonance imaging (MRI).

Alzheimer and It’s Possible Therapy: A Review

It is one of the most prevalent neurodegenerative disorder in the world, first described by a German Scientist, Alois Alzheimer, in 1906. 

Retroviral Elements in Human Evolution and Neural Development

Human embryogenesis and the development of its most unique product, the human brain, are believed to be precisely regulated by factors adopted during human
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Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation

Due to use as human vaccines and therapies, the clostridial neurotoxins (CNTs) have been subjected to decades of scientific investigation using biophysical, electrophysiological, and pharmacological approaches to establish mechanisms of toxin action.