Loading
Journal of Experimental Neurology
ISSN: 2692-2819
2023
Volume 4, Issue 1, p1-42
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease
Peter G. Noakes, William D. Phillips, Rosalind L. Jeffree, Frederik J. Steyn, Ernst J. Wolvetang, Rob D. Henderson, Pamela A. McCombe, Shyuan T. Ngo
Motor Neuron Disease (MND) of which Amyotrophic lateral sclerosis (ALS) is the most common form, is a devastating disorder where approximately 80% of patients die within 3-5 years of diagnosis. The highly variable clinical presentation, course, and prognosis between individuals suggests that a variety of factors underlie the pathogenesis of the disease.
J Exp Neurol, 2023, Volume 4, Issue 1, p1-5 | DOI: 10.33696/Neurol.4.067
Current Spinal Cord Injury Animal Models are Too Simplistic for Clinical Translation
Lara Gliksten, Ping K Yip
Spinal cord injury (SCI) is a devastating disease that has a global impact on individuals and society. The number of SCI cases in 2016 was 27 million worldwide, which was predominantly due to falls and road traffic collisions. Alarmingly, the number of new SCI cases in most countries has risen over the last few decades.
J Exp Neurol, 2023, Volume 4, Issue 1, p6-10 | DOI: 10.33696/Neurol.4.068
Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research
Serdar Alpdogan, Ke Li, Timo Sander, Jan Frederick Cornelius, Sajjad Muhammad
This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.
J Exp Neurol, 2023, Volume 4, Issue 1, p11-20 | DOI: 10.33696/Neurol.4.069
The Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic Methylphenidate
Nicholas King, Nachum Dafny
Methylphenidate (MPD) is psychostimulant, similar to cocaine and amphetamine, that is commonly used to treat attention deficit hyperactivity disorder and is increasingly being abused by healthy subjects for its psychoactive effects such as memory retention cognitive enhancement for young, adult and the elderly and recreation. MPD’s action on the brain reward/motive circuit is still under investigation
J Exp Neurol, 2023, Volume 4, Issue 1, p21-36 | DOI: 10.33696/Neurol.4.070
Benefits of Routine Inpatient EEG in Practice: Experience from a Level 4 University Hospital
Isha Snehal, Kanchan Kumari, Makayla Schissel, Arun Swaminathan
Routine inpatient EEGs have been part of epilepsy practices for years. We aim to improve current routine EEG practices by studying their role at a large university hospital. Methods: Inpatient routine EEGs from January-July 2021 were included and patients <5 yrs., EEGs repeated on the same patient were excluded. Indications, floor status, abnormality, day of study, neurology consultation, results, treatment changes, discharge status, and prior AED use were analyzed using SAS 9.4.
J Exp Neurol, 2023, Volume 4, Issue 1, p37-42 | DOI: 10.33696/Neurol.4.071
Recommended Articles
Study on Imaging Findings, Pathology and Treatment of Cerebellar Infarction
To explore the pathological mechanism and clinical treatment of cerebellar infarction through the clinical imaging changes of cerebellar infarction.
Prevention of Suicide in Persons with Progressive Neurological Diseases
People suffering with neurological diseases are at risk of committing suicide. A case-control study found increased risk of attempted suicide in patients with nine chronic neurological diseases [1]
Epilepsy in Neurodegenerative Disease: A Commentary
Case Summary - We published a case report of a 22-year-old woman who presented to our university hospital with encephalopathy and left hemiparesis of a few weeks duration.
What is the Time Necessary to be Able to Place Transpedicular Screws According to the Chosen Technique?
Transpedicular screw placement techniques are technically plaintiffs have relied on navigation intraoperative which is limited by its high cost, limited use of a fluoroscope with the radiological overexposure of the personnel of health and patient offers limited help when placing screws, and vertebral anatomical modifications especially in patients with degenerative pathology result an index of placement-related complications suboptimal of the screws [1,2].
Since its introduction by Roy-Camille [3] and Louis [4] in the seventies, the use of screws pedicle has increased markedly to the present day
Commentary on "Dysfunction of the Magnocellular Stream in Alzheimer Disease Evaluated by Pattern Electroretinograms and Visual Evoked Potentials"
Alzheimer’s disease (AD) represents the most common cause of dementia. Even if AD is commonly viewed as a disorder primarily of memory, there are several other additional domains, including visual function.
Should Food Cravings be Controlled or Understood?
Food Cravings (FC) is the term commonly used to describe sensations related to an intense desire for specific consumption [1], and there are features that we separate into internal and external aspects related to FC [2]
Skeletal Muscle Weakness Often Occurs in Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)
This commentary complements data reported in Clinical Biomechanics [1] reporting reduced maximal handgrip strength in numerous patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) in proportion to their lowered maximal physical performances.
Managing Acute Urinary Dysfunction for Neurologic Injury Patients
Damage to the nervous system can have direct and indirect impact on the lower urinary tract. Broadly speaking, damage can be grouped into three categories: problems with bladder storage, stress incontinence, and problems with bladder emptying [1].
To Stick or Not to Stick? Scalp and Intracranial EEG Evaluation Both Help Achieve Good Surgical and Neuropsychiatric Outcomes in Epilepsy Surgery up to 20 Years Post-Surgery
Epilepsy has a worldwide prevalence of about 50 million [1]. Seizure medications provide adequate control in two thirds of these patients but about a third are refractory to multiple medications and need surgery or other treatments [2].
Intracranial Pressure Monitoring in Aneurysmal Subarachnoid Hemorrhage -Current Practices and Challenges
The annual incidence of aneurysmal subarachnoid hemorrhage (SAH) in the United States is 6-16 cases per 100,000 population, with approximately 30,000 cases occurring each year.
Treatment of Neurological Manifestations of Mucopolysaccharidoses: Translational Considerations in Drug Development
Since the development of Ceredase® and Cerezyme® for the treatment of Gaucher disease in the early 1990s, treatment of lysosomal storage disorders via enzyme replacement therapy (ERT) has provided life-changing benefit to patients and their families.
Commentary to the Newly Rising Aquatic Exercise: Ai Chi
As aquatic therapy has become an important rehabilitative option, more exercise programs have emerged. Ai Chi, is one of the therapeutic aquatic exercise concepts with growing potential.
Microptofluidic Technology for Biodiagnostics of Traumatic Brain Injury: A Commentary
Traumatic brain injury (TBI) is a leading cause of death and neurological disability worldwide with millions of people sustaining and living with its long-term effects []. TBI is often categorized as mild, moderate and severe with primary injuries separated as either focal or diffuse, with the latter including contusions, intracranial hematomas and brain herniation.
Alzheimers Disease: A Brief Review
The worldwide prevalence of dementia is estimated to be over 45 million people. Alzheimer’s disease (AD) is the most common cause of dementia, responsible for 60-80% of cases.
Effect of Exosomes on Alzheimer’s Disease
AD is a neurodegenerative disease characterized by progressive cognitive impairment, behavioral changes, memory loss and executive dysfunction, all of which present serious threats to the health of older people.
Neurocysticercosis: Autoantibodies, Another Cog in the Wheel of Its Variable Pathogenicity
Neurological diseases are a major cause of disability and the second cause of death today. This reality has stimulated the search for predictive biomarkers facilitating early diagnosis and the design of appropriate treatments.
Comment On: Modulatory Effects of Magnetic Vestibular Stimulation on Resting-State Networks Can be Explained by Subject-Specific Orientation of Inner Ear Anatomy in the MR Static Magnetic Field
It was recently demonstrated that modulations in resting-state networks (RSNs) can be introduced via the stimulation of the vestibular inner ear by a strong magnetic field (>1 tesla) as used in magnetic resonance imaging (MRI).
Alzheimer and It’s Possible Therapy: A Review
It is one of the most prevalent neurodegenerative disorder in the world, first described by a German Scientist, Alois Alzheimer, in 1906.
Retroviral Elements in Human Evolution and Neural Development
Human embryogenesis and the development of its most unique product, the human brain, are believed to be precisely regulated by factors adopted during human
evolution that differentiate us from other species.
Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation
Due to use as human vaccines and therapies, the clostridial neurotoxins (CNTs) have been subjected to decades of scientific investigation using biophysical, electrophysiological, and pharmacological approaches to establish mechanisms of toxin action.