Journal of Cellular Signaling

2021

Volume 2, Issue 1, p1-84

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Review Article Open Access

Interrelation among TLR4, EGFR and Rab Proteins Induced by LPS

Jinling Zhuang, Xiaolei Liu, Guixi Mo, Jie Fan, Jing Tang

TLR4, as an on-membrane receptor of LPS, plays a crucial part in the process of sepsis, and EGFR phosphorylation promotes cell inflammation in response to LPS, which plays an indispensable role in modulating LPS/TLR4 signaling pathway. However, the mechanism of interaction between TLR4 and EGFR signaling is still unclear.

J Cell Signal, 2021, Volume 2, Issue 1, p1-8 | DOI: 10.33696/Signaling.2.031

Research Article Open Access

FOXP1 Interacts with MyoD to Repress its Transcription and Myoblast Conversion

Woodring E. Wright, Chuan Li, Chang-xue Zheng, Haley O. Tucker

Forkhead transcription factors (TFs) often dimerize outside their extensive family, whereas bHLH transcription factors typically dimerize with E12/E47. Based on structural similarities, we predicted that a member of the former, Forkhead Box P1 (FOXP1), might heterodimerize with a member of the latter, MYOD1 (MyoD).

J Cell Signal, 2021, Volume 2, Issue 1, p9-26 | DOI: 10.33696/Signaling.2.032

Research Article Open Access

The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling

Rui Yamaguchi, Reona Yamaguchi, Arisa Sakamoto, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguchi

Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. In this review, we focus on the regulatory mechanism of ectodomain shedding by ADAM10/17 metalloprotease via GPCR signaling. PAR2 and NK1R induce membrane blebbing, resulting in phosphatidylserine externalization in the cellular membrane, which is required for ADAM10/17 metalloprotease activation. Membrane-embedded dual oxidase 2 (DUOX2) has NADPH oxidase and peroxidas

J Cell Signal, 2021, Volume 2, Issue 1, p27-46 | DOI: 10.33696/Signaling.2.033

Commentary Open Access

S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages

Jagdish C Joshi, Bhagwati Joshi, Ian Rochford, Dolly Mehta

Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P).

J Cell Signal, 2021, Volume 2, Issue 1, p47-51 | DOI: 10.33696/Signaling.2.034

Review Article Open Access

Wnt Signaling Cascades and Their Role in Coronary Artery Health and Disease

Nadisha Weerackoon, Kushan L. Gunawardhana, Arya Mani

The Wnt signaling is classified as two distinct pathways of canonical Wnt/β-catenin signaling, and the non-canonical pathways of planar cell polarity and Wnt/Ca²⁺ pathways. However, the scientific discoveries in recent years have shown that canonical and noncanonical Wnts pathways are intertwined and have complex interaction with other major signaling pathways such as hedgehog, Hippo and TOR signaling.

J Cell Signal, 2021, Volume 2, Issue 1, p52-62 | DOI: 10.33696/Signaling.2.035

Review Article Open Access

Possible Therapeutic Use of Natural Compounds Against COVID-19

Nabab Khan, Xuesong Chen, Jonathan D. Geiger

The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to coronavirus disease-19 (COVID-19); a pandemic disease that has resulted in devastating social, economic, morbidity and mortality burdens. SARS-CoV-2 infects cells following receptor-mediated endocytosis and priming by cellular proteases.

J Cell Signal, 2021, Volume 2, Issue 1, p63-79 | DOI: 10.33696/Signaling.2.036

Short Communication Open Access

Neoadjuvant Therapy (NAT) in Localized Pancreatic Cancer: Should We Do It and What Should We Do?

Shreya Prasad Goyal, Morana Vojnic, Jung-in Yang, Jyothi Jose, Elliot Newman, Muhammad Wasif Saif

In 2019, approximately 56,770 new cases of pancreatic cancer were diagnosed in the United States, resulting in an estimated 45,750 deaths. Pancreatic cancer is one of the leading causes of cancer-related death, with a fiveyear survival rate of 9%. Based on the eighth edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic adenocarcinoma, multi-center analyses have validated that poorer prognosis is associated with node-positive disease (N1 and N2).

J Cell Signal, 2021, Volume 2, Issue 1, p80-84 | DOI: 10.33696/Signaling.2.037

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A Bioinformatics Protocol for Rational Design of Peptide Vaccines and the COVID-19 Rampage

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Comment on “Systematic Identification and Analysis of Light-responsive Circular RNA and Coexpression Networks in Lettuce (Lactuca sativa)”

Light is one of the most important environmental factors that affect plant growth and development, and it is also the main energy source for plants and other living things. Plants use light to assimilate inorganic matter into organic matter through photosynthesis and store them in the form of chemical energy. As an environmental signal, light mediates the

CO-Releasing Materials: Therapeutic Implications and Challenges towards Drug Discovery

Since last century, carbon monoxide (CO) generally regarded as “silent killer” and life-threatening for living organisms because of its colourless, odourless and poisonous nature. Haldane explored the poisonous nature of CO can be exerted as car-boxy hemoglobin (COHb) through hemoglobin dissociation parameters

Chest Pain in Repeated Emergency Department Visitors

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Journal of Cellular Signaling

2021

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