TLR4, as an on-membrane receptor of LPS, plays a crucial part in the process of sepsis, and EGFR phosphorylation promotes cell inflammation in response to LPS, which plays an indispensable role in modulating LPS/TLR4 signaling pathway. However, the mechanism of interaction between TLR4 and EGFR signaling is still unclear. In addition, there is an inextricable relationship between the activation of EGFR and the signaling pathway where Rab is located. This review mainly summarizes the research progress of the relationship among TLR4, EGFR and members of the Rab family, especially Rab5a under LPS stimulation, which also involves other signaling pathways of EGFR and Rab proteins.
LPS, Sepsis, TLR4, EGFR, Rab family