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Journal of Cellular Immunology

ISSN: 2689-2812

2021

Volume 3, Issue 2, p85-131

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Review Article Open Access

Review of the COVID-19 Risk in Multiple Sclerosis

Farhan Chaudhry, Cristina Jageka, Phillip D. Levy, Mirela Cerghet, Robert P Lisak

Severe respiratory syndrome coronavirus-2 (SARSCoV- 2) is the virus responsible for the novel coronavirus disease of 2019 (COVID-19) and has resulted in the death of over one million people around the world. COVID- 19’s presentation is highly heterogeneous as cases range from asymptomatic to rapidly progressive resulting in low survival rates. 

J Cell Immunol, 2021, Volume 3, Issue 2 | DOI: 10.33696/immunology.3.080
Commentary Open Access

Syncytiotrophoblast Extracellular Microvesicles in Preeclampsia

Chirag Ram, Robert W. Hu, Laxminarayana Korutla, Andreas Habertheuer, Prashanth Vallabhajosyula

Preeclampsia is a major cause of mortality and morbidity in expecting mothers and is one of the most common causes of pregnancy complications and premature birth [2]. Along with eclampsia, it is directly associated with 10-15% of maternal deaths [2]. 

J Cell Immunol, 2021, Volume 3, Issue 2 | DOI: 10.33696/immunology.3.081
Commentary Open Access

Immunomodulatory Effects of Cell Therapy after Myocardial Infarction

Joseph B Moore 4th, Marcin Wysoczynski

Myocardial infarction (MI) due to coronary artery stenosis compromises vascular endothelial integrity and increases vascular permeability. Concurrently, ensuing myocardial tissue death and necrosis results in the release of danger associated molecular patterns (DAMPs), cytokines, chemokines, bioactive lipids, as well as activation of the complement cascade. 

J Cell Immunol, 2021, Volume 3, Issue 2, p85-90 | DOI: 10.33696/immunology.3.082
Short Communication Open Access

IL-10 Responsiveness and Anti-TNF Therapy in Inflammatory Bowel Disease

Felicia M. Bloemendaal, Charlotte P. Peters, Anje A. te Velde, Cyriel Y. Ponsioen, Gijs R. van den Brink, Manon E. Wildenberg, Pim J. Koelink

Inflammatory bowel disease (IBD) is a multifactorial disease in which both genetic and environmental factors play an important role, although the precise cause remains obscure. It is clear that both the innate and adaptive immunity are involved in acquiring mucosal immune homeostasis in the intestine, which is dysregulated in IBD.

J Cell Immunol, 2021, Volume 3, Issue 2, p91-96 | DOI: 10.33696/immunology.3.083
Commentary Open Access

M1 Macrophages are More Susceptible to Necroptosis

Qin Hao, Steven Idell, Hua Tang

Macrophages are important cells of the innate immune system and play a crucial role in host immune defense against infection and injury [1-3]. Macrophages form the first line of defense against airborne particles and microbes through multiple functions including phagocytosis, production of cytokines and chemokines, and antigen presentation.

J Cell Immunol, 2021, Volume 3, Issue 2, p97-102 | DOI: 10.33696/immunology.3.084
Commentary Open Access

Structural Consequences of Variation in SARS-CoV-2 B.1.1.7

David A. Ostrov

New globally circulating SARS-CoV-2 strains are causing concern about evolution of virus transmissibility, fitness and immune evasion mechanisms. A variant emerging from the United Kingdom called SARS-CoV-2 VUI 202012/01, or B.1.1.7, is thought to exhibit increased transmissibility that results from replication 4-10 times faster than the original Wuhan virus (Wuhan-Hu-1). 

J Cell Immunol, 2021, Volume 3, Issue 2, p103-108 | DOI: 10.33696/immunology.3.085
Review Article Open Access

Pregnancy Specific Glycoproteins: A Possible Mediator of Immune Tolerance of Cancers

Junfei Zhao, Raul Rabadan, Arnold J. Levine

By the 1960’s there were a number of suggestions that the immune system played a role in detecting and rejecting cancerous cells. The next thirty to forty years saw a large number of attempts to identify the antigens found in a tumor that could lead to tumor rejection.

J Cell Immunol, 2021, Volume 3, Issue 2 | DOI: 10.33696/immunology.3.086
Commentary Open Access

IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer

Raoul André Droeser, Giandomenica Iezzi

Colorectal cancer (CRC) is the third most common cause of cancer related death worldwide. Its outcome depends on different factors. On one hand there are cancer related features, including mutations, microsatellite status, and methylation alterations.

J Cell Immunol, 2021, Volume 3, Issue 2, p118-121 | DOI: 10.33696/immunology.3.087
Short Communication Open Access

Understanding the Role of the Scabies Mite Microbiota in the Development of Novel Control Strategies

Sara Taylor, Katja Fischer

With a global prevalence of approximately 300 million people, scabies is one of the most common dermatological infectious diseases worldwide, and was recognised as a neglected tropical disease in 2017 by the World Health Organisation [1].

J Cell Immunol, 2021, Volume 3, Issue 2, p122-127 | DOI: 10.33696/immunology.3.088
Commentary Open Access

The First Viral Expression Model in Human Induced Pluripotent Stem Cells to Observe Enteroviral Infections In vitro

Stefan Peischard, Huyen Tran Ho, Nathalie Strutz-Seebohm, Guiscard Seebohm

Viruses recently caused global outbreaks of potentially severe diseases. The newly recognized corona virus, which is causing SARS-CoV-2 is the most recent example for this scenario. Potentially severe but not as prominent as the corona virus is the Coxsackievirus B3 (CVB3), which can cause fatal outcomes of myocarditis, meningitis, encephalitis and diabetes type 1 due to chronical infections of the heart, the brain, and the pancreas.

J Cell Immunol, 2021, Volume 3, Issue 2, p128-131 | DOI: 10.33696/immunology.3.089
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