Journal of Cellular Immunology

2021

Volume 3, Issue 2, p68-131

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Review Article Open Access

Review of the COVID-19 Risk in Multiple Sclerosis

Farhan Chaudhry, Cristina Jageka, Phillip D. Levy, Mirela Cerghet, Robert P Lisak

The ongoing pandemic of the novel coronavirus of 2019 (COVID-19) has resulted in over 1 million deaths, primarily affecting older patients with chronic ailments. Multiple sclerosis (MS) patients have been deemed particularly vulnerable given their high rates of disability and increased susceptibility to infections. There have also been concerns regarding disease-modifying therapy (DMT) during the pandemic as many DMTs may increase the risk of infection due to some of their immunosuppressive properties.

J Cell Immunol, 2021, Volume 3, Issue 2, p68-77 | DOI: 10.33696/immunology.3.080

Commentary Open Access

Syncytiotrophoblast Extracellular Microvesicles in Preeclampsia

Chirag Ram, Robert W. Hu, Laxminarayana Korutla, Andreas Habertheuer, Prashanth Vallabhajosyula

Preeclampsia, a placental disease, is typically characterized by hypertension and proteinuria in pregnant mothers. There is a need for improved noninvasive detection and diagnosis of this condition. Extracellular microvesicles (EVs), including exosomes, are tissue specific nanoparticles released by many tissue types including the placenta into peripheral circulation.

J Cell Immunol, 2021, Volume 3, Issue 2, p78-84 | DOI: 10.33696/immunology.3.081

Commentary Open Access

Immunomodulatory Effects of Cell Therapy after Myocardial Infarction

Joseph B Moore 4th, Marcin Wysoczynski

Myocardial infarction (MI) due to coronary artery stenosis compromises vascular endothelial integrity and increases vascular permeability. Concurrently, ensuing myocardial tissue death and necrosis results in the release of danger associated molecular patterns (DAMPs), cytokines, chemokines, bioactive lipids, as well as activation of the complement cascade.

J Cell Immunol, 2021, Volume 3, Issue 2, p85-90 | DOI: 10.33696/immunology.3.082

Short Communication Open Access

IL-10 Responsiveness and Anti-TNF Therapy in Inflammatory Bowel Disease

Felicia M. Bloemendaal, Charlotte P. Peters, Anje A. te Velde, Cyriel Y. Ponsioen, Gijs R. van den Brink, Manon E. Wildenberg, Pim J. Koelink

Inflammatory bowel disease (IBD) is a multifactorial disease in which both genetic and environmental factors play an important role, although the precise cause remains obscure. It is clear that both the innate and adaptive immunity are involved in acquiring mucosal immune homeostasis in the intestine, which is dysregulated in IBD.

J Cell Immunol, 2021, Volume 3, Issue 2, p91-96 | DOI: 10.33696/immunology.3.083

Commentary Open Access

M1 Macrophages are More Susceptible to Necroptosis

Qin Hao, Steven Idell, Hua Tang

Macrophages play a crucial role in host innate immune defense against infection and tissue injury. Although macrophage activation and polarization has been well studied, we know less regarding the role of macrophage activation/polarization in inflammationassociated necrotic cell death. By using bone marrow-derived macrophages, we have recently demonstrated that M1 macrophages are much more susceptible than M0 and M2 subtypes of macrophages to necrotic cell death.

J Cell Immunol, 2021, Volume 3, Issue 2, p97-102 | DOI: 10.33696/immunology.3.084

Commentary Open Access

Structural Consequences of Variation in SARS-CoV-2 B.1.1.7

David A. Ostrov

New globally circulating SARS-CoV-2 strains are causing concern about evolution of virus transmissibility, fitness and immune evasion mechanisms. A variant emerging from the United Kingdom called SARS-CoV-2 VUI 202012/01, or B.1.1.7, is thought to exhibit increased transmissibility that results from replication 4-10 times faster than the original Wuhan virus (Wuhan-Hu-1).

J Cell Immunol, 2021, Volume 3, Issue 2, p103-108 | DOI: 10.33696/immunology.3.085

Review Article Open Access

Pregnancy Specific Glycoproteins: A Possible Mediator of Immune Tolerance of Cancers

Junfei Zhao, Raul Rabadan, Arnold J. Levine

Cancer immunotherapy relies upon the immune system recognizing and killing cancer cells. Tumors can elude recognition by readapting existing mechanisms of immune control and suppression. Here we explore the hypothesis that cancers repurpose the immune suppression employed during pregnancy to protect the allogeneic fetus. Those mechanisms are reviewed and shown to be employed both in pregnancy and by tumors.

J Cell Immunol, 2021, Volume 3, Issue 2, p109-117 | DOI: 10.33696/immunology.3.086

Commentary Open Access

IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer

Raoul André Droeser, Giandomenica Iezzi

The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated.

J Cell Immunol, 2021, Volume 3, Issue 2, p118-121 | DOI: 10.33696/immunology.3.087

Short Communication Open Access

Understanding the Role of the Scabies Mite Microbiota in the Development of Novel Control Strategies

Sara Taylor, Katja Fischer

With a global prevalence of approximately 300 million people, scabies is one of the most common dermatological infectious diseases worldwide, and was recognised as a neglected tropical disease in 2017 by the World Health Organisation. Scabies is especially prevalent in economically disadvantaged communities and disproportionately affects children in poor and overcrowded living conditions.

J Cell Immunol, 2021, Volume 3, Issue 2, p122-127 | DOI: 10.33696/immunology.3.088

Commentary Open Access

The First Viral Expression Model in Human Induced Pluripotent Stem Cells to Observe Enteroviral Infections In vitro

Stefan Peischard, Huyen Tran Ho, Nathalie Strutz-Seebohm, Guiscard Seebohm

Viruses recently caused global outbreaks of potentially severe diseases. The newly recognized corona virus, which is causing SARS-CoV-2 is the most recent example for this scenario. Potentially severe but not as prominent as the corona virus is the Coxsackievirus B3 (CVB3), which can cause fatal outcomes of myocarditis, meningitis, encephalitis and diabetes type 1 due to chronical infections of the heart, the brain, and the pancreas.

J Cell Immunol, 2021, Volume 3, Issue 2, p128-131 | DOI: 10.33696/immunology.3.089

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Journal of Cellular Immunology

2021

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