Commentary Open Access
Volume 3 | Issue 2 | DOI: https://doi.org/10.33696/immunology.3.087

IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer

  • 1University Center for Gastrointestinal and Liver Diseases, Clarunis, University of Basel, Basel, Switzerland
  • 2Department of Surgery, Ente Ospedaliero Cantonale and Università Svizzera Italiana, Lugano, Switzerland
+ Affiliations - Affiliations

Corresponding Author

Raoul André Droeser, raoulandre.droeser@clarunis.ch

Received Date: January 30, 2021

Accepted Date: March 22, 2021


The positive prognostic role of the immune environment in colorectal cancer is widely accepted. However, there are few data about the prognostic significance of interleukin-22 in human colorectal cancer which is still debated. In our study we could demonstrate for the first time a positive prognostic role of interleukin-22 in human colorectal cancer relying on its capacity to induce in tumor cells the production of chemokines recruiting into the tumor microenvironment neutrophils associated with a favorable clinical outcome.



Human colorectal cancer, IL-22, Neutrophils, Tissue microarray, Prognosis, Chemokines

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