Journal of Cellular Immunology

2020

Volume 2, Issue 3, p74-142

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Short Communication Open Access

MicroRNA Signature Targeting Transient Receptor Potential Channels in the Prognosis and Therapy of Cancer

Giorgio Santoni, Consuelo Amantini, Massimo Nabissi, Federica Maggi, Maria Beatrice Morelli

MicroRNAs (miRNAs) are small non-coding RNAs that modulate protein-coding mRNAs. Numerous miRNAs are expressed in human and 50% of human miRNAs are associated with carcinogenesis. Specific miRNAs are expressed in different cancer tissues and modulation of their expression is associated to different tumor stages and clinical outcomes.

J Cell Immunol, 2020, Volume 2, Issue 3, p74-79 | DOI: 10.33696/immunology.2.023

Commentary Open Access

Trade-off and Cardiotonic Steroid Signaling: Natriuresis Maintains Sodium Balance at The Expense of Cardiac Fibrosis

Steven T. Haller, Joseph I. Shapiro

The pivotal work by Zijian Xie provided groundbreaking insights describing that the Na/K-ATPase (NKA), in addition to being an essential ion pump, also functions as a signal transducer with the capability to interact with multiple signaling partners. As an extension of this, our work along with a large body of work from the laboratories of Blaustein and Hamlyn as well as Bagrov and Fedorova, demonstrated that there were two major classes of endogenous NKA ligands or cardiotonic steroids (CTS), those from the cardenolide class such as ouabain and those which were bufadienolide such as marinobufagenin.

J Cell Immunol, 2020, Volume 2, Issue 3, p80-83 | DOI: 10.33696/immunology.2.024

Review Article Open Access

Breast Implant-associated Anaplastic Large Cell Lymphoma: A Review with Emphasis on the Role of Brentuximab Vedotin

Anthony Stack, Nadia Ali, Nadia Khan

Breast implant-associated anaplastic large cell lymphoma is a recently recognized complication of textured breast implants. It typically presents as unilateral peri-implant swelling approximately 7-10 years after implantation. While the course is usually indolent, breast implant-associated anaplastic large cell lymphoma may form a locally invasive mass and metastasize to regional lymph nodes or beyond to distant sites.

J Cell Immunol, 2020, Volume 2, Issue 3, p80-89 | DOI: 10.33696/immunology.2.025

Commentary Open Access

A novel therapeutic strategy for antifibrotic based on a new gene NS₅ATP₉

Jing Zhao, Jun Cheng

In this article, we introduced a screening of anti-fibrotic drugs focused on new genes. More precisely, we screened and cloned 127 new genes, reporting on a potential target gene and two promising drugs for fibrosis. Among 127 genes, hepatitis C virus nonstructural protein 5A transactivated protein 9 (NS5ATP9), which expression is significantly upregulated by tenofovir disoproxil fumarate (TDF)/tenofovir alafenamide fumarate (TAF), suppresses hepatic stellate cells (HSCs) and HFL1 cells (lung fibroblasts) activation.

J Cell Immunol, 2020, Volume 2, Issue 3, p94-101 | DOI: 10.33696/immunology.2.027

Commentary Open Access

Friend or Foe? Opposing Functions of O-GlcNAc in Regulating Inflammation

Miranda Machacek, Chad Slawson, Patricia J. McLaughlin

Effector CD4⁺ T cells (i.e. Th1, Th2, Th17) are essential in the adaptive immune system’s specific elimination of different classes of pathogens, such as viruses, bacteria, and parasites, while regulatory T cells shut these inflammatory responses off once a pathogen has been cleared. Interestingly, effector T cells preferentially utilize

J Cell Immunol, 2020, Volume 2, Issue 3, p102-107 | DOI: 10.33696/immunology.2.028

Short Communication Open Access

M₁ and M₂Macrophages Polarization via mTORC₁Influences Innate Immunity and Outcome of Ehrlichia Infection

Ibrahim Ahmed, Nahed Ismail

Human monocytic ehrlichiosis (HME) is an emerging life-threatening tick-borne disease caused by the obligate intracellular bacterium Ehrlichia chaffeensis. HME is often presented as a nonspecific flu-like illness characterized by presence of fever, headache, malaise, and myalgia. However, in some cases the disease can evolve to a severe form, which is commonly marked by acute liver injury followed by multi-organ failure and toxic shock-like syndrome.

J Cell Immunol, 2020, Volume 2, Issue 3, p108-115 | DOI: 10.33696/immunology.2.029

Review Article Open Access

CD₁₄₆-Positive Tumors are Associated with Venous Thromboembolism

A. Joshkon, J. Stalin, W. Traboulsi, L. Vivancos-Stalin, M. Nollet, R. Lacroix, R.Bachelier, F. Dignat-George, A. Bertaud, A.S. Leroyer, H. Fayyad-Kazan, N. Bardin, M.Blot-Chabaud

The role of CD146 and its soluble form have been intensely reviewed in the processes of cancer and inflammation. However, how CD146 is linked to coagulation and thrombotic events remains unclear. The aim of this paper is to shed light on this topic and clarify the contribution of CD146 as a procoagulant factor.

J Cell Immunol, 2020, Volume 2, Issue 3, p116-123 | DOI: 10.33696/immunology.2.030

Research Article Open Access

Basophil Activation Tests BAT: Degranulation, Cytometry and Chemotaxis in Drug Allergy

Maria de Lourdes Irigoyen Coria, María Isabel Rojo Gutierrez, David Solís Hernández, Ruben Humberto Meyer Gómez, Isabel Leyva Carmona, Jaime Mellado Abrego, Gloria Castillo Narváez, Isabel Guerrero Vargas

To Increase the knowledge on Drugs Hypersensitivity Reactions (DHRs); activation, development of reliable diagnostic tests for better: selection of studies, diagnosis, identification of risk groups, prevention, cross-reactions, severs skin drug reactions and alternative therapeutics.

J Cell Immunol, 2020, Volume 2, Issue 3, p124-142 | DOI: 10.33696/immunology.2.031

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Journal of Cellular Immunology

2020

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