Volume 2, Issue 3, p74-142
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
MicroRNA Signature Targeting Transient Receptor Potential Channels in the Prognosis and Therapy of Cancer
This short communication would to be the continuation of the Santoni’s paper entitled “Targeting Transient Receptor Potential Channels by MicroRNAs drives tumor development and progression” published in: Calcium Signaling, Advances in Experimental Medicine and BiologyJ Cell Immunol, 2020, Volume 2, Issue 3, p74-79 | DOI: 10.33696/immunology.2.023
Trade-off and Cardiotonic Steroid Signaling: Natriuresis Maintains Sodium Balance at The Expense of Cardiac Fibrosis
The pivotal work by Zijian Xie provided groundbreaking insights describing that the Na/K-ATPase (NKA), in addition to being an essential ion pump, also functions as a signal transducer with the capability to interact with multiple signaling partners. As an extension of this, our work along with a large body of work from the laboratories of Blaustein and Hamlyn as well as Bagrov and Fedorova, demonstrated that there were two major classes of endogenous NKA ligands or cardiotonic steroids (CTS), those from the cardenolide class such as ouabain and those which were bufadienolide such as marinobufagenin.J Cell Immunol, 2020, Volume 2, Issue 3, p80-83 | DOI: 10.33696/immunology.2.024
Breast Implant-associated Anaplastic Large Cell Lymphoma: A Review with Emphasis on the Role of Brentuximab Vedotin
Anaplastic large cell lymphoma (ALCL) represents a heterogeneous group of T-cell lymphomas, which characteristically express CD30 and are associated with translocations involving the anaplastic lymphoma kinase (ALK) gene on chromosome 2p23 . Systemic ALCL, which may be subclassified by the presence or absence ofJ Cell Immunol, 2020, Volume 2, Issue 3, p80-89 | DOI: 10.33696/immunology.2.025
By the suppression of subtractive hybridization (SSH) and yeast-two hybrid system, 127 new genes were screened, cloned, and registered at GenBank (Table 1) [1,2]. These new genes which were found in the liver have been demonstrated to be closely related to liver diseases such as viral hepatitis, liver fibrosis, fatty liver, andJ Cell Immunol, 2020, Volume 2, Issue 3, p94-101 | DOI: 10.33696/immunology.2.027
Effector CD4+ T cells (i.e. Th1, Th2, Th17) are essential in the adaptive immune system’s specific elimination of different classes of pathogens, such as viruses, bacteria, and parasites, while regulatory T cells shut these inflammatory responses off once a pathogen has been cleared . Interestingly, effector T cells preferentially utilizeJ Cell Immunol, 2020, Volume 2, Issue 3, p102-107 | DOI: 10.33696/immunology.2.028
M1 and M2 Macrophages Polarization via mTORC1 Influences Innate Immunity and Outcome of Ehrlichia Infection
Macrophages are innate immune cells that play a key role in regulation of innate and adaptive immune responses against infections with several pathogens as they respond to pathogens and tissue injury, serve as antigen presenting cells priming the adaptive immune response, drive inflammation and host defense as well as repairingJ Cell Immunol, 2020, Volume 2, Issue 3, p108-115 | DOI: 10.33696/immunology.2.029
CD146, also known as melanoma cell adhesion molecule (Mel-CAM), MUC18, S-Endo1, A32 antigen, metastasis cell adhesion molecule (MET-CAM), and hemopoietic cell adhesion molecule (HEMCAM), is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is constituted of two variable regions (V) and threeJ Cell Immunol, 2020, Volume 2, Issue 3, p116-123 | DOI: 10.33696/immunology.2.030
Objective: To Increase the knowledge on Drugs Hypersensitivity Reactions (DHRs); activation, development of reliable diagnostic tests for better: selection of studies, diagnosis, identification of risk groups, prevention, cross-reactions, severs skin drug reactions and alternative therapeutics.J Cell Immunol, 2020, Volume 2, Issue 3, p124-142 | DOI: 10.33696/immunology.2.031
Although NK cells are recognized as effector lymphocytes of the innate immune system, they also regulate the adaptive immune response by releasing inflammatory cytokines and developing immunological memory. Unlike other lymphocytes such as T or B cells, NK cells do not express rearrangeable, antigen-specific receptors.
The transient receptor potential mucolipin 1 (TRPML1) is an endolysosomal channel belonging to the TRP family. Clinically, mutations of TRPML1 have been responsible for a severe lysosomal storage disorder called mucolipidosis type IV.
In order to implement the knowledge of cancer to monitor its evolution and setting, in the last decade, new minimally invasive and repeatable samples collection have been developed such as liquid biopsy.
Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case
Breast cancer is the second most common cancer worldwide, affecting nearly one in eight women. Accurate cancer staging is essential for determining the patient’s prognosis and for choosing the appropriate treatment.
However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.
Tyrosine kinase-type cell surface receptor HER2- targeted therapies have dramatically improved breast cancer patients’ outcome compared to conventional chemotherapies. In the clinic, HER2 monoclonal antibody trastuzumab with chemotherapy represent the gold standard treatment of HER2-positive breast cancer.
Breast Cancer is the most regularly diagnosed type of cancer in women in the world, making up on its own 25% of all cases, or nearly 2 million new cases in 2018, and 15% of all cancer related deaths, or around 626,700 deaths for that same year.
In 2020 we published a series of 18 patients who underwent neoadjuvant chemotherapy (NACT) and vaginal radical trachelectomy (VRT) as a fertility sparing alternative in stage 1B2 cervical cancer.
At present, breast cancer is more frequently diagnosed in women than in men. According to global cancer statistics, each year more than 1,675,000 women are diagnosed and more than 500,000 of them die. Some subtypes of breast cancer have been described.
Aging is a complicated process not yet fully understood. Driven by a variety of stressors such as infectious agents, radiation, intracellular stress, and stressing metabolic conditions, molecular damage occurs over time. Among many consequences, age-related unchecked molecular damage leads to immunosenescence, a hallmark of aging.
Since the declaration of COVID-19 as a pandemic in March 2020 , there have been more than 100 million reported cases of COVID-19 worldwide and more than 2.1 million deaths .
Inhibition of Autophagy and Immune Response: Alpha-fetoprotein Stimulates Initiation of Liver Cancer
Alpha-fetoprotein (AFP) is a tumorous marker for the diagnosis of hepatocellular carcinoma (HCC), it is synthesized mainly by the embryo yolk sac, fetal liver and the gastrointestinal tract. AFP belongs to the family of protein products of albuminoid genes, which are located in tandem arrangement in chromosome 4 (region 4q11-q13).
DNA microsatellites are tandemly repeating short (1-6 base pairs) DNA motifs, such as mononucleotide (A)n, dinucleotide (CA)n, trinucleotide (CAG)n, and tetranucleotide (AAAG)n, with each motif potentially repeating up to 50 times.
How medications whose major biologic effect is to reduce bile acid synthesis favorably affect the course of a variety of cholestatic and metabolic liver diseases is not immediately apparent. Also, the most frequently used plasma biomarkers for evaluating benefit, alkaline phosphatase and conjugated bilirubin , provide different information. The former may be misleading with respect to the course of the disease and therefore it is important to focus on the pathophysiologic basis for its use.
Ovarian Function Suppression Plus Aromatase Inhibitors or Tamoxifen in Premenopausal HR-positive Breast Cancer
Breast cancer is the most common type of malignant tumor in women, accounting for 30% of women’s cancer, while the mortality rate ranks second among women’s cancer. Twenty-five percent of all breast cancer patients are premenopausal patients, and 7% of patients are younger than 40 years old.
Phosphoinositol 3 kinase (PI3K) defines a class of lipid kinases that have the ability to phosphorylate the inositol ring 3?-OH group in inositol phospholipids and therefore produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3) . PI3K encompasses a family of enzymes divided into: Class IA PI3K which includes three isomers (?, ?, ?) and Class IB which include the group (?).
MicroRNA Signature Targeting Transient Receptor Potential Channels in the Prognosis and Therapy of Cancer
This short communication would to be the continuation of the Santoni’s paper entitled “Targeting Transient Receptor Potential Channels by MicroRNAs drives tumor development and progression” published in: Calcium Signaling, Advances in Experimental Medicine and Biology
High Lymph Node Positive to Sampled Ratio as a Potential Indication for Postoperative Radiation Therapy in Patients with pN2 Non-small-cell Lung Cancer
Despite advances in cancer treatment and screening, lung cancer remains the leading cause of cancer death in the United States. The majority of cases are locally advanced non-small cell lung cancer (NSCLC), treatment of which usually includes a bi- or tri-modality therapy utilizing a combination of surgery, chemotherapy, and radiation therapy.
S1P Generation by Sphingosine Kinase-2 in Recruited Macrophages Resolves Lung Inflammation by Blocking STING Signaling in Alveolar Macrophages
Acute respiratory distress syndrome (ARDS) is the major cause of mortality among hospitalized acute lung injury (ALI) patients. Lung macrophages play an important role in maintaining the tissue-fluid homeostasis following injury. We recently showed that circulating monocytes recruited into the alveolar space suppressed the stimulator of type 1 interferon genes (STING) signaling in alveolar macrophages through sphingosine-1-phosphate (S1P).
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