To Increase the knowledge on Drugs Hypersensitivity Reactions (DHRs); activation, development of reliable diagnostic tests for better: selection of studies, diagnosis, identification of risk groups, prevention, cross-reactions, severs skin drug reactions and alternative therapeutics.

Over 20 years after the first description of NSAIDinduced Corneal Melt (NICM), a rare but potentially devastating visual complication induced by a topically applied medication, the optimal prevention and treatment for this condition remain unknown creating a clinical conundrum for eye care professionals and challenge for eye researchers.

The direct and indirect Basophil Activation Test (BAT) are well known for their capacity to predict the presence of an IgEmediated peanut allergy resulting in a reduction of expensive and time-consuming oral food challenge (OFC) tests. Although the BAT is a promising test, false-positive and false-negative outcomes are observed .

Bacterial metabolism affects the effectiveness of antibiotics. Bacterial metabolism is linked to the ability of an antibiotic to be bactericidal or bacteriostatic because a bacterium can metabolize carbohydrates that affect its pH and its ability to use the proton motive force (PMF). When the pH is low, there is more availability of protons that can help to power the proton motive force needed for the efflux of antibiotics.

Pancreatic Ductal Adenocarcinoma (PDAC) remains one of the most lethal solid tumor diagnoses given its limited treatment options and dismal prognosis. Its complex tumor microenvironment (TME), heterogeneity, and high propensity for drug resistance are major obstacles in developing effective therapies. Here, we highlight the critical role of Redox effector 1 (Ref-1) in PDAC progression and drug resistance, focusing on its redox regulation of key transcription factors (TFs) such as STAT3, HIF1α, and NF-κB, which are pivotal for tumor survival, proliferation, and immune evasion.