Journal of Cellular Signaling

2020

Volume 1, Issue 3, p42-101

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Mini Review Open Access

The Effect of Glucocorticoids on Angiogenesis in the Treatment of Solid Tumors

Bing Liu, Julie E. Goodwin

Glucocorticoids (GCs) are defined by their role in maintaining glucose homeostasis and natural GCs are a class of corticosteroids secreted by the adrenal cortex. Cortisol is the most important natural GC in humans. Cellular cortisol levels are regulated by the tissue-specific metabolic enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD 1 and 2); 11β-HSD 1 converts inactive cortisone to active cortisol, while 11β-HSD 2 has the opposite function.

J Cell Signal, 2020, Volume 1, Issue 3, p42-49 | DOI: 10.33696/Signaling.1.011

Commentary Open Access

Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties

Hozaifa Metwally, Tadamitsu Kishimoto

Signal transducer and activator of transcription 1 (STAT1) protein plays a pivotal role in various biological processes especially the regulation of innate and adaptive immune responses. Phosphorylation represents a key step in the activation of STAT1 and its transcriptional outcome. Binding of various extracellular ligands to their specific cell-surface receptors activates different phosphorylation of STAT1 followed by a distinct change of gene expression patterns.

J Cell Signal, 2020, Volume 1, Issue 3, p50-55 | DOI: 10.33696/Signaling.1.012

Review Article Open Access

Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS

Alla Mitrofanova, Yelena Drexler, Sandra Merscher, Alessia Fornoni

Being a sophisticated and highly organized living system, mammals harbor a large number of biomolecular machineries which represent a dynamic and complex network of interconnections responsible for the effective operation, development and survivability of their body cells. Sphingolipids are a special class of lipids in eukaryotic cells, which have recently gained the attention of researchers because of their involvement in several fundamental processes of living cells, including proliferation

J Cell Signal, 2020, Volume 1, Issue 3, p56-69 | DOI: 10.33696/Signaling.1.013

Mini Review Open Access

Metabolic Syndrome is an Important Cornerstone in the Health-disease Line and Pathological Organ Interaction

Ferah Armutcu, Suheyla Akyol, Huseyin Vural

Today, metabolic syndrome (MS) has been regarded as a very important disease due to its complex multifactorial etiology and damage to different organs. In general, obesity, dyslipidemia, hypertension, hyperglycemia, and insulin resistance are the main metabolic abnormalities of the MS. Compared with the others; in particular, insulin resistance and central obesity are considered the main causes in the pathogenesis

J Cell Signal, 2020, Volume 1, Issue 3, p70-75 | DOI: 10.33696/Signaling.1.014

Editorial Open Access

Machine Learning for Healthcare: Emerging Challenges and Opportunities in Disease Diagnosis

Sachin Kumar Deshmukh

Diagnosis is a process that identifies, explains, or establishes the individual’s disease from its symptoms and signs. Early and precise diagnosis is crucial since it influences the efficacy of treatment and avoids longterm complications for the infected person. Further, in the case of infectious diseases, undiagnosed patients can transmit the disease to a healthy population unknowingly. Besides, most of the diseases evolve with the time that significantly affects the clinical outcomes.

J Cell Signal, 2020, Volume 1, Issue 3, p76-78 | DOI: 10.33696/Signaling.1.015

Commentary Open Access

Kv1.3 Potassium Channels: Promising Therapeutic Targets in Hematological Malignancies

Theresa Lowinus, Tanima Bose, Luca Simeoni, Burkhart Schraven, Ursula Bommhardt

Voltage-gated Kv1.3 potassium channels control the membrane potential, cellular activation and cell death. Kv1.3 channels have been extensively studied in autoimmune disorders and are promising drug targets for the treatment of solid cancer.

J Cell Signal, 2020, Volume 1, Issue 3, p79-86 | DOI: 10.33696/Signaling.1.016

Review Article Open Access

Is Citrate A Critical Signal in Immunity and Inflammation?

Alessia Zotta, Zbigniew Zaslona, Luke A. O’Neill

When immune cells are activated, they undergo metabolic change in order to have sufficient energy to function effectively. The Krebs cycle is one of the most important pathways involved in this response and citrate, a critical component of this pathway, regulates carbohydrate and lipid metabolism.

J Cell Signal, 2020, Volume 1, Issue 3 | DOI: 10.33696/Signaling.1.017

Commentary Open Access

Using Mitochondrial Trifunctional Protein Deficiency to Understand Maternal Health

Jason W. Miklas, Hannele Ruohola-Baker

Fatty acid oxidation disorders unfortunately can result in the sudden unexplained death of infants. Mitochondrial trifunctional protein (MTP) deficiency is one such disease where long-chain fatty acids cannot be fully oxidized through beta-oxidation which, can lead to cardiac arrythmias in an infant.

J Cell Signal, 2020, Volume 1, Issue 3, p97-101 | DOI: 10.33696/Signaling.1.018

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Journal of Cellular Signaling

2020

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