Mini Review Open Access
Volume 1 | Issue 3 | DOI: https://doi.org/10.33696/Signaling.1.014

Metabolic Syndrome is an Important Cornerstone in the Health-disease Line and Pathological Organ Interaction

  • 1Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
  • 2Suleyman Demirel University, School of Medicine, Isparta, Turkey
  • 3RWTH University, Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, Aachen, Germany
+ Affiliations - Affiliations

Corresponding Author

Ferah Armutcu, drferah@gmail.com

Received Date: June 12, 2020

Accepted Date: July 24, 2020


Background: Metabolic syndrome (MS) is an important clinical and public health problem, especially in Western society, and is affecting more and more people worldwide. Although most cases of MS are considered obese and insulin-resistant, they are characterized by inflammatory cytokine activity and chronic low-grade inflammation. Also, assumptions about the role of MS and organ interaction during target organ damage become increasingly important.

Method: For this study, online research and screening were carried out in electronic databases such as PubMed, Web of Science, and Google Scholar; using the terms “metabolic syndrome” and “organ crosstalk” as keywords.

Results: Due to the unpredictable clinical course and treatment uncertainty in this multi-factor chronic disease, increased organ interaction and complications lead to an increase of biomarkers in blood circulation, each of which has diagnostic potential. Therefore, a better understanding of inflammatory triggers and organ interferences will also help determine therapeutic targets and prevent organ damage associated with metabolic syndrome.

Conclusion: This mini review presents an overview of the relationship between MS and organ crosstalk. More research is needed to fully elucidate the relationship between MS and organ crosstalk, the pathological conditions it causes, and biomarkers related to MS.


Metabolic syndrome, Organ crosstalk, Inflammation, COVID-19, Biomarker

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