Journal of Cellular Immunology

2021

Volume 3, Issue 4, p201-295

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Research Article Open Access

Efficacy of Therapeutic Plasma Exchange Alone or in Combination with Ruxolitinib for the Treatment of Penn Class 3 and 4 Cytokine Release Syndrome Complicating COVID-19

W. Larry Gluck, Wesley M. Smith, Sean P. Callahan, Robert A. Brevetta, Antine E. Stenbit, Julie C. Martin, Anna V. Blenda, Sergio Arce, W. Jeffery Edenfield

This study was conducted to validate the efficacy of therapeutic plasma exchange (TPE) in reducing the excessive cytokine load complicating a subset of patients with severe COVID-19 and respiratory compromise. Additionally, this trial explored molecular signals of potential benefit by the addition of JAK inhibition to TPE. Findings included an improvement in cytokine excess and oxygenation along with incremental benefit in cytokine reduction with the addition of ruxolitinib.

J Cell Immunol, 2021, Volume 3, Issue 4, p201-206 | DOI: 10.33696/immunology.3.100

Commentary Open Access

The Importance of miRNA Identification During Respiratory Viral Infections

Ivan Martinez-Espinoza, Ma Del Rocio Banos-Lara, Antonieta Guerrero-Plata

The expression of small non-coding RNA MicroRNAs (miRNAs) during respiratory viral infections is of critical importance as they are implicated in the viral replication, immune responses and severity of disease pathogenesis. Respiratory viral infections have an extensive impact on human health across the globe. For that is essential to understand the factors that regulate the host response against infections.

J Cell Immunol, 2021, Volume 3, Issue 4, p207-214 | DOI: 10.33696/immunology.3.101

Review Article Open Access

Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic

Kae Myriam Pusic, Lisa Won, Richard Paul Kraig, Aya Darinka Pusic

Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics.

J Cell Immunol, 2021, Volume 3, Issue 4, p215-225 | DOI: 10.33696/immunology.3.102

Review Article Open Access

Immunotherapy for Dogs: Still Running Behind Humans

Hans Klingemann

Despite all good intentions, dogs are still running behind humans in effective cancer immunotherapies. The more effective treatments in humans, like infusions of CAR-T and NK-cells are not broadly pursued for canines due to significant costs, the rather complicated logistics and the lack of targetable surface antigens. Monoclonal antibodies are challenging to develop considering the limited knowledge about canine target antigens and about their mode of action.

J Cell Immunol, 2021, Volume 3, Issue 4, p226-233 | DOI: 10.33696/immunology.3.103

Commentary Open Access

Body Mass Index and COVID-19: Likely Causes for Obesity and Undernutrition Correlation with Disease Severity

Nicolas Vitale

Very early on clinicians around the world reported that in addition to aging and various heart pathologies, excess of body weight, especially obesity is a major risk factor for the severity of COVID-19 infection. The multitude of symptoms that have been described from human patients likely arises from the broad distribution of ACE2, a member of the angiotensin receptor family, the receptor for SARS-CoV-2, among which adipose tissue is a prominent one.

J Cell Immunol, 2021, Volume 3, Issue 4, p234-239 | DOI: 10.33696/immunology.3.104

Commentary Open Access

Novel Combination Treatments for AML

Montserrat Estruch, Camilla Vittori, Teresa Muñoz-Montesinos, Kristian Reckzeh, Kim Theilgaard-Mönch

Drug resistance of cancer patients toward chemotherapy remains a major problem in the clinic. Hence, understanding the intrinsic and acquired molecular mechanisms of drug resistance in cancer patients is paramount to identify relevant targets for therapeutic interventions that enhance chemotherapy response, and ultimately improve clinical outcome.

J Cell Immunol, 2021, Volume 3, Issue 4, p240-245 | DOI: 10.33696/immunology.3.105

Research Article Open Access

Expression of Pu.1, C/Ebpα and Bach₁ Transcription in Immune Cells in Patients with Cancer

Gulnur K. Zakiryanova, Elena Kustova, Nataliya T. Urazalieva, Emile T. Baimukhametov, Valeriy A. Makarov, Galina V. Shurin, Narymzhan N. Nakisbekov, Michael R. Shurin

Dysfunction and abnormal differentiation of immune cells and hematopoietic precursors are well described in patients with cancer, although the role of transcription factors in these defects is not well established. Here, we evaluated expression of C/EBPa, PU.1 and BACH1 transcription factors in lymphoid and myeloid cells, including NK cells, T cells, neutrophils and monocytes, isolated from healthy donors and cancer patients.

J Cell Immunol, 2021, Volume 3, Issue 4, p246-257 | DOI: 10.33696/immunology.3.106

Review Article Open Access

Neurological Manifestations Associated with SARS-CoV-2 Invasion of the Autonomous Nervous System

Erwan Poivet, Matthieu Daniel, Fernando A. Bozza, Tarek Sharshar, Pierre-Marie Lledo

Although pneumonia and acute respiratory failure are the most frequent and severe complications of patients with SARS-CoV-2 infection, many of them also develop neurological signs and symptoms. From sickness behavior to coma, neurological disorders are associated with impairment of consciousness and dysautonomia, resulting from brainstem dysfunction.

J Cell Immunol, 2021, Volume 3, Issue 4, p258-277 | DOI: 10.33696/immunology.3.107

Commentary Open Access

Commentary on “A Vaccine for Photodynamic Immunogenic Cell Death: Tumor Cell Caged b y Cellular Disulfide–Thiol Exchange for Immunotherapy”

Jie Zang, Haiqing Dong

Tumor immunotherapy, including monoclonal antibody of immune checkpoint blockade, therapeutic antibody, cancer vaccine and cell therapy, etc., is to restart and maintain the tumor immune cycle, restore the normal antitumor immune response of the body, so as to control and eliminate the tumor. Among them, tumor vaccine, which can elicit robust immune response and produce sustained immune memory effect, is particularly favored in the treatment and prevention of tumor recurrence.

J Cell Immunol, 2021, Volume 3, Issue 4, p294-295 | DOI: 10.33696/immunology.3.109

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Journal of Cellular Immunology

2021

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