Review Article Open Access
Volume 3 | Issue 4 | DOI: https://doi.org/10.33696/immunology.3.102

Environmental Enrichment and Its Benefits for Migraine: Dendritic Cell Extracellular Vesicles as an Effective Mimetic

  • 1Department of Neurology, The University of Chicago, Chicago, Il 60637-1470, USA
+ Affiliations - Affiliations

Corresponding Author

Aya Darinka Pusic, apusic@bsd.uchicago.edu

Received Date: May 11, 2021

Accepted Date: July 03, 2021


Environmental enrichment produces beneficial effects in the brain at genetic, molecular, cellular and behavior levels, and has long been studied as a therapeutic intervention for a wide variety of neurological disorders. However, the complexity of applying a robust environmental enrichment paradigm makes clinical use difficult. Accordingly, there has been increased interest in developing environmental enrichment mimetics, also known as enviromimetics. Here we review the benefits of environmental enrichment for migraine treatment, and discuss the potential of using extracellular vesicles derived from interferon gamma-stimulated dendritic cells as an effective mimetic.


Environmental enrichment, Enviromimetics, Migraine, Spreading depression, Extracellular vesicles, Exosomes, Oxidative stress, Interferon gamma

Author Information X