Volume 1, Issue 3, p55-114
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Treatment of Neurological Manifestations of Mucopolysaccharidoses: Translational Considerations in Drug Development
Since the development of Ceredase® and Cerezyme® for the treatment of Gaucher disease in the early 1990s, treatment of lysosomal storage disorders via enzyme replacement therapy (ERT) has provided life-changing benefit to patients and their families.J Exp Neurol, 2020, Volume 1, Issue 3, p55-61 | DOI: 10.33696/Neurol.1.011
As aquatic therapy has become an important rehabilitative option, more exercise programs have emerged. Ai Chi, is one of the therapeutic aquatic exercise concepts with growing potential.J Exp Neurol, 2020, Volume 1, Issue 3, p73-79 | DOI: 10.33696/Neurol.1.013
Traumatic brain injury (TBI) is a leading cause of death and neurological disability worldwide with millions of people sustaining and living with its long-term effects . TBI is often categorized as mild, moderate and severe with primary injuries separated as either focal or diffuse, with the latter including contusions, intracranial hematomas and brain herniation.J Exp Neurol, 2020, Volume 1, Issue 3, p80-88 | DOI: 10.33696/Neurol.1.014
The worldwide prevalence of dementia is estimated to be over 45 million people. Alzheimer’s disease (AD) is the most common cause of dementia, responsible for 60-80% of cases.J Exp Neurol, 2020, Volume 1, Issue 3, p89-98 | DOI: 10.33696/Neurol.1.015
AD is a neurodegenerative disease characterized by progressive cognitive impairment, behavioral changes, memory loss and executive dysfunction, all of which present serious threats to the health of older people.J Exp Neurol, 2020, Volume 1, Issue 3, p99-102 | DOI: 10.33696/Neurol.1.016
Neurological diseases are a major cause of disability and the second cause of death today. This reality has stimulated the search for predictive biomarkers facilitating early diagnosis and the design of appropriate treatments.J Exp Neurol, 2020, Volume 1, Issue 3, p103-108 | DOI: 10.33696/Neurol.1.017
Comment On: Modulatory Effects of Magnetic Vestibular Stimulation on Resting-State Networks Can be Explained by Subject-Specific Orientation of Inner Ear Anatomy in the MR Static Magnetic Field
It was recently demonstrated that modulations in resting-state networks (RSNs) can be introduced via the stimulation of the vestibular inner ear by a strong magnetic field (>1 tesla) as used in magnetic resonance imaging (MRI).J Exp Neurol, 2020, Volume 1, Issue 3, p109-114 | DOI: 10.33696/Neurol.1.018
While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.
Focal Aggregates of Normal or Near Normal Uveal Melanocytes (FANNUMs) in the Choroid. A Practical Clinical Category of Small Ophthalmoscopically Evident Discrete Melanocytic Choroidal Lesions
Multiple types of discrete melanocytic choroidal lesions are currently recognized, including benign choroidal nevi, choroidal malignant melanomas, patches of choroidal melanocytosis, and foci of choroidal melanocytes stimulated paraneoplastically by a systemic nonmelanoma malignant neoplasm.
The hepatitis C virus (HCV) genome was isolated during the late 1980s using molecular cloning techniques. It is recognized as the cause of most cases of percutaneously transmitted non-A, non-B hepatitis. It is estimated, that up to 200 million people worldwide are infected with the hepatitis C virus (HCV), more than 3% of the world population.
Despite the advances in diagnostic and therapeutic field, colorectal cancer (CRC) still remains the third most common cause of death worldwide, with more than 600,000 cancer-related deaths per year.
Five months into the COVID-19 pandemic, the U.S. death toll from the virus has now surpassed 100,000 people. Many more cases remain nationwide, while an unknown number of patients currently harbor the virus asymptomatically. While health officials are now optimistic regarding the decline in prevalence and number of deaths due to COVID-19 and the possibility of a vaccine by the fall, we cannot lose sight of the bigger picture: the next pandemic.
The etiology of fetal growth restriction is rooted in inadequate maternal-placental vascular malperfusion (MVM) of the placenta. Risk factors for MVM are broad and include maternal, fetal, and placental antecedent determinants.
Case report is an important kind of article in medicine. The case report can be in several forms. A report might be on the new finding, new technique, rare condition or lesson learnt [1-2]. The case report on pitfall and error is interesting. It is useful for giving lesson learnt to the reader.
Patients of all ages with motor disorders expect highquality assessments and evidence- based treatment . In university hospitals, alongside medical training and treatment of patients, research  is an integral part of the skills for medical professionals e.g. doctors, nurses, occupational therapists and physiotherapists.
It gives us great pleasure to introduce readers with our international peer-reviewed, open access journal. Journal of Physical Medicine and Rehabilitation is devoted to publish original research, reviews, and clinical reports on key areas of Physical Medicine and Rehabilitation and related fields.
Cancer is a worldwide public health issue that affects millions of people every year. In 2018 there were 17 million newly documented cases of cancer globally (8.8 million in men and 8.2 million in women), leading to 9.6 million deaths. Cancer is a vastly heterogeneous disease, with over 100 different types of cancer currently identified in humans; the most common types of cancer are lung, female breast, bowel and prostate, these four types account for more than 40% of all new cancer case
Intentional facial expression of emotion named facial mimic is critical to healthy social interactions. Psychological and functional implications of the facial paralysis present a devastating management problem to patients afflicted because their face have an important challenge of facial muscles that are fundamental also for affective communication.
Diagnosis is a process that identifies, explains, or establishes the individual’s disease from its symptoms and signs. Early and precise diagnosis is crucial since it influences the efficacy of treatment and avoids longterm complications for the infected person. Further, in the case of infectious diseases, undiagnosed patients can transmit the disease to a healthy population unknowingly. Besides, most of the diseases evolve with the time that significantly affects the clinical outcomes.
Lung cancer remains the leading cause of cancer related death in the United States with mortality rates surpassing breast, prostate, brain, and colorectal cancers combined. Recent data shows that susceptibility for both men and women for developing invasive lung and bronchogenic carcinoma peak after the age of 70 years.
A 59-year-old left hand dominant female was evaluated by a physical therapist. The patient had an 8-year history of chronic intermittent left elbow pain with a recent exacerbation occurring after moving furniture. Aggravating factors included holding a coffee cup, picking up trash bags, and lifting heavy dishes. Symptoms were eased by ice and Meloxicam as prescribed by her primary care provider.
By deduction from complexity of (behavioral) models, we develop an entropic computational tool to distinguish erroneous/redundant eye movements from task relevant eye movements.
Modern Rehabilitation Strategies of Post-Stroke Motor Disfunctions: Functional Electrical Stimulation and Biofeedback-Stabilometric Postural Training
More than 80% of patients after a stroke have limited daily activity due to a complex polymorphic motor deficiency of various nature and severity, which leads to postural disorders (PD) . Because of paresis, develops different changes in the musculoskeletal system (MSS) such as PD, restrictions of movements in the joints, impaired
Continuous spikes during slow wave sleep (CSWS) syndrome is an age-related and self-limited severe epileptic encephalopathy characterized by electrical status epilepticus in sleep (ESES) on electroencephalogram, seizures, and developmental regression
Progression of Autoantibodies Anti-Gad and Anti-IA2 in Type 1A Diabetics Aged 5 to 21 Years in Cote d’Ivoire
Type 1A diabetes is an autoimmune disease, the final consequence of a slow and gradual process of ß-cell destruction of pancreatic islet Langerhans cells leading to ketoacidosis in the absence of treatment. This destruction of the β cells, responsible for the production of insulin, begins with the initiation of the autoimmune reaction triggered by certain environmental factors and, after several years of evolution, leads to the clinical signs of the disease when the mass of ß cells
Breast Cancer is the most regularly diagnosed type of cancer in women in the world, making up on its own 25% of all cases, or nearly 2 million new cases in 2018, and 15% of all cancer related deaths, or around 626,700 deaths for that same year.
No Studies in Stroke Regarding Brain fMRI Activity and Pelvic Floor Muscle Training/Activation - Only Studies in Non-stroke Population: A Review of Neuroimaging Studies
Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent in poststroke patients, leading to major impact on the quality of life (QoL) and healthcare resources. Pelvic floor muscle training (PFMT) has, over the past two decades, been recommended as first-line treatment for neurologically healthy patients with lower urinary tract symptoms (LUTS).
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