Journal of Clinical Cardiology

Coronary artery disease continues to be the greatest cause of global mortality. The prevalence of coronary artery disease in patients with severe aortic stenosis varies widely, from 80% in extreme high-risk trials to only 15% in more recent low risk trials.

Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.

Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.

Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.

Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee

Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.

In this review address the changes of LA structure and function in patients with CSFP according to our research and existing literature, therefore provide further insight into its clinical significance and pathophysiological mechanisms.

Dementia and hypertension are highly prevalent, epidemiologically related chronic conditions disproportionately affecting older persons; approximately 97% of persons with dementia and 66% with hypertension are over the age of 65.

The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).

Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.

Internists as well as cardiologists often receive echocardiogram reports which failed to offer a clear definition of the aortic stenosis (AS) severity due to discordant data regarding the aortic valve gradients and the valve area. Sometimes AS appears severe according to the valve area criteria, in spite of the fact that gradients across the valve are not in the severe range.

Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits and is also one of the major reasons of repeated ED visits, causing around 6% of these cases [1]. Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause.

The contribution of β3-AR activation towards ischemiareperfusion (IR) damage largely depends on the disease stage, severity, experimental model as well as drug specificities which should be considered when investigating β3-AR pharmacology for potential therapeutic applications. These conceptions largely contribute to the discrepancies of the subsequent role of β3-AR activation in the cardiovascular disease process. 

The COVID-19 pandemic started at the end of 2019 and remains carrying a health threat and significant economic consequences. Over the last two years, COVID-19 has been the main Public Health issue, and has impacted regular healthcare systems, with significant build-up of waiting lists and delay in optimum management of other serious medical conditions including heart diseases and cancer.

Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.

After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19.

Atrial septal defect (ASD) is a common congenital heart disease diagnosed during childhood. Persistently increased pulmonary blood flow and dilated right atrium (RA) and right ventricle (RV) result in multiple symptoms and morbidities in adulthood; untreated adults may develop exercise intolerance, congestive heart failure, atrial tachyarrhythmias, pulmonary hypertension (PH), embolic stroke, or even death.

Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee