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Journal of Clinical Cardiology
ISSN: 2694-5088
Richard Kones
Cardiometabolic Research Institute, USA
Beta 3-Adrenergic Receptor (β3-AR) Activation at the End of Sustained Ischemia and/or Early Reperfusion may Prove to be a Valuable Cardioprotective Strategy
Estimated Plasma Volume Status (ePVS) for Diastolic Heart Failure in the Intensive Care Unit: A Retrospective Cohort Study
COVID-19 Delays Presentation and Management of Acute Coronary Syndrome
Journal of Clinical Cardiology is aiming to stand out and publish remarkable findings in the major areas of cardiovascular medicine emphasizing on diagnostic, therapeutic and disease management sections. We are focusing on quality outcomes of relevant research that will empower the field of clinical cardiology in various ways. Our expert editorial panel will evaluate all articles and effective suggestions will be provided to all articles submitted to the journal.
Coronary Artery Disease in Athletes-Insights from Cardiac CT
Exercise is widely recognized for its cardiovascular benefits, including reduced mortality and a lower risk of cardiovascular events. However, recent studies suggest that athletes may exhibit a paradoxical increase in coronary artery calcium (CAC) and high-risk plaque morphology. Additionally, there is considerable conflicting evidence and numerous gaps in current research on this topic. With the growing population of athletes, particularly “Master Athletes’, understanding the implications of coronary atherosclerosis in this group is increasingly important.
Echocardiographic Predictors of Atrial Fibrillation after Coronary Artery Bypass Grafting: A Speckle Tracking Echocardiography Study
The most prevalent major arrhythmia, atrial fibrillation (AF), is causing major morbidity and mortality throughout any population. AF patients have longer hospital admissions, a higher risk of death, and worse outcomes than stroke patients without AF. Chronic AF makes a stroke more likely. Moreover, it may result in additional serious side effects such as hemodynamic disturbance, heart failure, and even death.
Semaglutide-inducing Non-arteritic Anterior Ischemic Optic Neuropathy and Ipsilateral Blindness -A Rare Presentation
Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic nerve edema and neuropathy, involving the axons that make up the optic nerve but not including the optic nerve head (also known as posterior ischemic optic neuropathy). Anterior ischemic optic neuropathy can be further divided into arteritic (giant cell arteritis) and non-arteritic subtypes. The pathophysiology of NAION remains unclear and is currently thought to result from impaired blood flow in the posterior ciliary arteries that supply these segments of the optic nerve.
Cholesterol Paradox: Understanding and Implications for Clinical Practice and Education
Cholesterol has long been recognized as a major risk factor for cardiovascular diseases with traditional guidelines emphasizing the reduction of LDL cholesterol and triglycerides, and the increase of HDL cholesterol to lower morbidity and mortality. However, recent studies have questioned the predictive value of these traditional cholesterol measures in coronary artery disease. The concept of the cholesterol paradox has emerged, highlighting instances where elevated LDL cholesterol or high HDL levels have an inverse relationship with cardiovascular risk, particularly in certain diseased populations.
The Diagnostic Accuracy of Ankle Brachial Index in Relation to Coronary Computed Tomography in Coronary Artery Disease
Arterial stiffness and loss of recoil indicate arterial aging and arteriosclerosis, which heighten the risk of cardiovascular issues, particularly ischemic heart disease. Advances in technology, particularly coronary computed tomography angiography (CCTA), allow for accurate detection of coronary luminal stenosis with high image quality. Due to its noninvasive nature and high specificity and negative predictive value, CCTA is widely utilized for assessing coronary artery disease (CAD). It also facilitates the analysis of plaque characteristics and calcium levels in the coronary arteries, providing further insights into coronary risk.
Incorporation of Non-invasive, Contrast-free, and Minimal Radiation Parameters in the Diagnostic Modalities of Coronary Artery Disease
Ischemic heart disease is the major cause of morbidity and mortality. The diagnosis of chronic coronary syndrome is a challenge as most of the diagnostic investigation are either invasive or involve radiation or contrast material. The aim of our study was to find a scoring system comprising diagnostic parameters which are non-invasive and involve minimal radiation or contrast material and yet have high diagnostic yield.
Coronary Revascularization in the Era of Transcatheter Aortic Valve Replacement: Treat the Patient, Manage the Disease
Coronary artery disease continues to be the greatest cause of global mortality. The prevalence of coronary artery disease in patients with severe aortic stenosis varies widely, from 80% in extreme high-risk trials to only 15% in more recent low risk trials.
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease
Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?
Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.
The Value of the Left Atrial Appendage Orifice Perimeter of 3D Model Based on 3D TEE Data in the Choice of Device Size of LAmbre™ Occluder
Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.
Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee
Hypertrophic Cardiomyopathy and the Troponins: The Enigma Remains
Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.
Shaping the Future of Cardiac Wellness: Exploring Revolutionary Approaches in Disease Management and Prevention
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide. Effective prevention and management strategies are essential to reduce the burden of CVDs. This review summarizes recent advances in the prevention and management of CVDs. In terms of prevention, lifestyle modifications, such as diet, exercise, and smoking cessation, remain important strategies.
Cardiac Amyloidosis: A Survey of Current Awareness, Diagnostic Modalities, Treatment Practices, and Clinical Challenges Among Cardiologists in Selected Middle Eastern Countries
Cardiac amyloidosis (CA) is a progressive disease affecting the normal cardiac structure and function. CA could be isolated or associated with a spectrum of organ involvement, including the kidneys, lungs, nervous systems, bones, and others.
Commentary on: Peptidylglycine alpha-amidating Monooxygenase is Required for Atrial Secretory Granule Formation
The electron-dense spherical granules found in the perinuclear region of atrial myocytes store and release both proatrial and probrain natriuretic peptides (proANP and proBNP, respectively). Mature ANP and BNP produce vasodilation and natriuresis and inhibit the renin-angiotensin and sympathetic nervous systems.
Predicting COVID-19 Hospitalized Patients’ Outcome with Homocysteine
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Lipoprotein Apheresis: First FDA Indicated Treatment for Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).
Chest Pain in Repeated Emergency Department Visitors
Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits and is also one of the major reasons of repeated ED visits, causing around 6% of these cases [1]. Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause.
External Validation of Four Cardiovascular Risk Prediction Models
Background and Purpose: Cardiovascular disease (CVD) is a leading cause of death and disability in the world. Many CVD risk prediction models have been created, but those most widely used in clinical settings have not been externally validated, a significant gap addressed herein. Methods: Using the Multi-Ethnic Study of Atherosclerosis (MESA), we have externally validated the Framingham Risk Score, ASSIGN (Assessing the cardiovascular disease risk using SIGN) risk score, Atherosclerotic Cardiovascular Disease (ASCVD) risk score, and the European SCORE model, which were selected based on popularity among clinicians and frequency of clinical use.
Beta 3-Adrenergic Receptor (β3-AR) Activation at the End of Sustained Ischemia and/or Early Reperfusion may Prove to be a Valuable Cardioprotective Strategy
The contribution of β3-AR activation towards ischemiareperfusion (IR) damage largely depends on the disease stage, severity, experimental model as well as drug specificities which should be considered when investigating β3-AR pharmacology for potential therapeutic applications. These conceptions largely contribute to the discrepancies of the subsequent role of β3-AR activation in the cardiovascular disease process.
COVID-19 Delays Presentation and Management of Acute Coronary Syndrome
The COVID-19 pandemic started at the end of 2019 and remains carrying a health threat and significant economic consequences. Over the last two years, COVID-19 has been the main Public Health issue, and has impacted regular healthcare systems, with significant build-up of waiting lists and delay in optimum management of other serious medical conditions including heart diseases and cancer.
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease
Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.
Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19
After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19.
Beneficial Effects of Surgical Closure of Atrial Septal Defect Outweigh Potential Complications in Sick Infants
Atrial septal defect (ASD) is a common congenital heart disease diagnosed during childhood. Persistently increased pulmonary blood flow and dilated right atrium (RA) and right ventricle (RV) result in multiple symptoms and morbidities in adulthood; untreated adults may develop exercise intolerance, congestive heart failure, atrial tachyarrhythmias, pulmonary hypertension (PH), embolic stroke, or even death.
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