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Journal of Experimental Neurology
ISSN: 2692-2819
Hooshang Lahooti
University of Sydney, Australia
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Journal of Experimental Neurology is an international publication primarily dedicated to publish original research and novel findings in the neuroscience field. This journal offers a great opportunity to the neuroscientists to discuss and exchange their ideas and major advances in clinical and experimental neurology. The journal publishes original articles, reviews, editorials, letters, and short communications in all major concepts of experimental neurology.
Cerebrovascular Dysfunction in Alzheimer’s Disease and Transgenic Rodent Models
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementia (ADRD) are the primary causes of dementia that has a devastating effect on the quality of life and is a tremendous economic burden on the healthcare system. The accumulation of extracellular beta-amyloid (Aβ) plaques and intracellular hyperphosphorylated tau-containing neurofibrillary tangles (NFTs) in the brain are the hallmarks of AD.
Treatment of Sleep Disorders in Children with Atopic Dermatitis: What's New?
Atopic dermatitis (AD), also known as atopic eczema, is a chronic and inflammatory disease caused by an interaction of genetic, immunological, and environmental factors. It is characterized by skin lesions and itching and progresses with periods of improvement and worsening.
Homeostatic Synaptic Plasticity may be Targeted for the Prevention of Post-Stroke Epilepsy
Stroke is the most common cause of acquired epilepsy, with up to 30 percent of stroke survivors developing epilepsy over time. However, the mechanisms leading to neuronal hyperexcitability and epilepsy in stroke survivors are not fully understood. In a recently published work, we demonstrate that ischemic stroke induces homeostatic plasticity regulation in the surviving neurons in the peri-stroke area.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Comparing Contrast Agent Enhancement: The Value of Artificial Intelligence/Machine Learning
Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
The Spread of Spectrin in Ataxia and Neurodegenerative Disease
Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Glutaminergic Signaling in the Nucleus Accumbens Modulates the Behavioral Response to Acute and Chronic Methylphenidate
Methylphenidate (MPD) is a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, and is being increasingly misused as a recreational drug and cognitive enhancer
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke
Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.
Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics
Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].
A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans
Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.
In the Mind of the US Olympic Athletes; Longevity Advantage and Its Relation to Nervous System Disorders and Mental Illness
In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts.
Commentary: Use of BACTRAC Proteomic Database-Uromodulin Protein Expression During Ischemic Stroke
Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.
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