Loading
Journal of Experimental Neurology
ISSN: 2692-2819
Hooshang Lahooti
University of Sydney, Australia
Featured Article
Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases
Featured Article
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models
Featured Article
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
About this Journal
Journal of Experimental Neurology is an international publication primarily dedicated to publish original research and novel findings in the neuroscience field. This journal offers a great opportunity to the neuroscientists to discuss and exchange their ideas and major advances in clinical and experimental neurology. The journal publishes original articles, reviews, editorials, letters, and short communications in all major concepts of experimental neurology.
Articles
Demyelinating Polyneuropathy as the Initial Presentation of Poems Syndrome. The Challenge of Early Diagnosis. A Case Report and Literature Review
POEMS syndrome is a rare paraneoplastic multisystemic disorder caused by an underlying monoclonal plasma-cell dyscrasia and characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder, and Skin changes. Because early manifestations often overlap with other conditions such as chronic inflammatory demyelinating polyneuropathy (CIDP) and multiple myeloma, diagnosis is frequently delayed.
The Cost of Safety: Balancing Biosafety and Histologic Integrity in Prion Research
Prion diseases, or transmissible spongiform encephalopathies (TSEs), represent a group of incurable and invariably fatal neurodegenerative disorders driven by the pathological misfolding of the prion protein (PrP) [1–6]. These diseases are characterized by a progressive clinical course and, despite their significant impact on human [7–17] and animal [1,10,18–30] health, currently lack effective therapeutic interventions [31–34] and are limited in early-stage diagnostics [1,7,31–33]. Given the broad host range of prion diseases, together with the absence of effective treatments and limited antemortem diagnostic options, continued prion disease research remains essential.
Beyond Clinical Trials: Perampanel across the Lifespan in Contemporary Epilepsy Practice
Perampanel (PER) occupies a singular place in anti-seizure pharmacology. As the only anti-seizure medication (ASM) that acts through selective, non-competitive blockade of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, the principal mediators of fast excitatory neurotransmission in the brain, it brings a mechanistic distinctiveness that sets it apart from agents targeting sodium channels, calcium currents, or synaptic vesicle proteins
Extracellular Vesicles in Angelman Syndrome: Expanding UBE3A Role beyond a Cell Autonomous Mechanism
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of maternal UBE3A, an E3 ubiquitin ligase essential for neuronal development, synaptic plasticity, and cognitive function. AS has traditionally been viewed as a cell-autonomous disorder in which intracellular UBE3A deficiency drives neuronal dysfunction. However, recent evidence suggests that impaired extracellular vesicle (EV)-mediated intercellular communication also contributes to disease pathophysiology.
Commentary: Does First-Line Treatment Impact Outcomes in Trisomy 21-Associated Infantile Epileptic Spasms Syndrome?
Trisomy 21 (T21) is the most common chromosomal disorder and is associated with a substantially increased risk of epilepsy, affecting approximately 5–10% of children [1,2]. Among infants with T21, infantile epileptic spasms syndrome (IESS) is the most common epilepsy syndrome of the first year of life, with a reported prevalence of 0.6–13%, approximately 100-fold higher than in the general population [3,4]. The occurrence of IESS adds an additional burden to a population already at risk for neurodevelopmental impairment, making early recognition and effective treatment particularly important [2,5,6].
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Impact of Cellular Senescence on Neurodegenerative Diseases during the COVID-19 Pandemic: Suitable Targets Required to Eliminate Cellular Senescence
We recently reviewed the scientific literature that elucidates the impact of cellular senescence on COVID-19 complications.
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Comparing Contrast Agent Enhancement: The Value of Artificial Intelligence/Machine Learning
Gadolinium-based contrast agents (GBCAs) work by shortening the T1, T2, and T2* relaxation time constants of adjacent water protons in tissues.
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
The Spread of Spectrin in Ataxia and Neurodegenerative Disease
Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologies
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populations
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births [1]. It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1
Inhalational Anaesthetics: An Update on Mechanisms of Action and Toxicity
Inhalational anaesthetics have been used for induction and maintenance of general anaesthesia for more than 150 years. In human medicine desflurane, sevoflurane, and isoflurane are commonly used.
Glutaminergic Signaling in the Nucleus Accumbens Modulates the Behavioral Response to Acute and Chronic Methylphenidate
Methylphenidate (MPD) is a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, and is being increasingly misused as a recreational drug and cognitive enhancer
Testing the Efficacy of Minocycline Treatment in an Awake, Female Rat Model of Repetitive Mild Head Injury
Minocycline is being tested in clinical trials for the treatment of stroke and traumatic brain injury. As an antibiotic it reduces microglia activation. Can minocycline be used to treat mild repetitive head injury? To that end, minocycline was tested in a novel, closed-head, momentum exchange model of repetitive mild head injury in female rats impacted while fully awake. Magnetic resonance imaging (MRI) revealed there was no brain damage or contusion attesting to the mild nature of the head impacts in this model.
Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD/ADRD
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke
Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled.
Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics
Anorexia nervosa (AN) is a neuropsychic syndrome characterized by restriction of energy intake relative to requirements, abnormally low body weight and fear of weight gain, resulting in extreme emaciation and even death [1].
A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans
Spinal cord injury (SCI) to the terminal segments of the spinal cord causes severe disruption of the neural circuitry of the bladder, resulting in neurogenic underactive bladder (nUAB). We developed a rodent lumbosacral injury model to investigate the effects of bladder function and structure.
In the Mind of the US Olympic Athletes; Longevity Advantage and Its Relation to Nervous System Disorders and Mental Illness
In a recent study of 8124 US Olympic athletes, Antero et al. [1] found that the US Olympic athletes live 5 years longer than their general counterparts.
About Scientific Archives
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.