Journal of Experimental Neurology

Case Report Open Access

Atypical Presentation of NMDA Receptor Encephalitis in a 4-year-old Male: A Case Report of Successful Treatment with Rituximab and Tetrabenazine

Felix A. Appiah , Sadat Gül , Nicole Brescia

N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder historically associated with anti-NMDA receptor antibodies, predominantly described in young women with ovarian teratomas. This case presents a 4-year-old male with NMDA receptor encephalitis, highlights the importance of early detection and aggressive treatment of movement disorders in pediatric autoimmune encephalitis and contributes to the limited literature on the successful use of tetrabenazine for symptomatic control in children.

J Exp Neurol, 2025, Volume 6, Issue 2, p64-66 | DOI: 10.33696/Neurol.6.109

Original Research Open Access

Prophylactic and Therapeutic Modulation of the OGF-OGFr Axis Ameliorates Angiogenesis-associated Pathology in Experimental Autoimmune Encephalomyelitis

Laura B. Odom , Ian S. Zagon , Patricia J. McLaughlin

Multiple sclerosis (MS) is a chronic autoimmune disease associated with inflammation and neurodegeneration of the central nervous system. MS pathogenesis includes angiogenesis, the formation of new blood vessels from existing vasculature. Angiogenesis facilitates the migration of inflammatory immune cells across the blood-brain barrier in MS. The opioid growth factor (OGF)-opioid growth factor receptor (OGFr) axis is a potential target for limiting angiogenesis in MS. 

J Exp Neurol, 2025, Volume 6, Issue 2, p67-75 | DOI: 10.33696/Neurol.6.110

Commentary Open Access

Implications of Office-Based Pterygium Surgery for Neurological Practice

Adam Hidad

The transition of surgical procedures from hospital-based to office-based settings has raised important considerations regarding patient safety, cost-effectiveness, and procedural outcomes. The recent study by Cremers et al. (2025) evaluates the safety and efficacy of office-based pterygium surgery, reporting low complication rates, minimal postoperative pain, and significant cost savings. Of particular neurological interest is the reported case of central retinal artery occlusion following a peribulbar injection containing epinephrine, highlighting the potential vascular risks associated with local anesthetic administration.

J Exp Neurol, 2025, Volume 6, Issue 2, p76-82 | DOI: 10.33696/Neurol.6.111

Review Article Open Access

Drug-Induced Peripheral Neuropathy: Focus on Newer Offending Agents

Mahjoubi Yasmine Salem

Peripheral neuropathy (PN) is a common neurological disorder resulting from peripheral nerve damage, significantly contributing to morbidity and adversely affecting patients’ quality of life. Drug-induced peripheral neuropathy (DIPN) accounts for 2-4% of cases and typically manifesting as distal, symmetrical sensory polyneuropathy. The growing diversity of medications complicates DIPN diagnosis, often leading to underreporting and mismanagement due to overlapping symptoms with other conditions. This systematic review analyzed DIPN literature up to September 15, 2024, emphasizing both established and emerging neurotoxic drugs.

J Exp Neurol, 2025, Volume 6, Issue 2, p83-104 | DOI: 10.33696/Neurol.6.112