Journal of Experimental Neurology

Review Article Open Access

The Role and Mechanism of Autoantibodies in Dysimmunity Related Neurological Diseases

Yongchao Xu , Wenshan Zhao , Jiali Shan , Yi Zhang , Yuqing Gong , Leping Wang , Jialu Ye , Jiawen Dong , Yalun Chen , Yuyang Ye , Keting Jin , Jinhui Hong , Qiang Ke , Kaibo Zhang , Jing Wu

Autoantibodies are antibodies produced by B cells capable of attacking their own tissues or organs after loss of immune tolerance. A large body of literature shows that autoantibodies play an important role in neurological diseases associated with immune abnormalities. Nowadays, neurological disorders are an important cause of disability and death in populations around the world, so it is important to study the role and mechanisms of autoantibodies in neurological disorders associated with immune abnormalities.

Review Article Open Access

Atezolizumab Induced Neurotoxicity : A Systematic Review

Mahjoubi Yasmine Salem

Traditionally, cytotoxic chemotherapy dominated cancer treatment, but in recent years, immunotherapies, mainly immune checkpoint inhibitors (ICIs), have revolutionized cancer therapy by enhancing T-cell responses. Despite their efficacy, ICIs can induce toxicities affecting various organs, including the nervous system. Although rare, neurological complications of ICIs can be severe, contributing significantly to treatment-related mortality.

Commentary Open Access

Gender Differences in the Association between Sedentary Time, Screen Time, and Depression

Lauren Elizabeth Kleidermacher , Mark Olfson

Previous research has indicated a relationship between sedentary time and depression, but it is unclear how this relationship differs by gender or subtype of sedentary behavior. This commentary expands our previous study on screen time, gender, and depression by examining relationships between sedentary time, gender, and depression. This additional analysis utilized the 2017- March 2020 National Health and Nutrition Examination Survey (NHANES).

Research Article Open Access

Testing the Efficacy of Minocycline Treatment in an Awake, Female Rat Model of Repetitive Mild Head Injury

Rosemarie Hightower , Eric Brengel , Sophia Prom , Praveen Kulkarni , Craig F Ferris

Minocycline is being tested in clinical trials for the treatment of stroke and traumatic brain injury. As an antibiotic it reduces microglia activation. Can minocycline be used to treat mild repetitive head injury? To that end, minocycline was tested in a novel, closed-head, momentum exchange model of repetitive mild head injury in female rats impacted while fully awake. Magnetic resonance imaging (MRI) revealed there was no brain damage or contusion attesting to the mild nature of the head impacts in this model.

Case Report Open Access

Acute Obstructive Hydrocephalus and Acute Cerebellar Ischemic Stroke as a Complication of Takayasu Arteritis in a Young Male Patient: A Rare Case Report

Muhammad Hashim , Asif Khan , Muhammad Khadim , Sabir Shah , Awais Ahmad , Farhan Shahzad

Introduction: Takayasu arteritis is a rare type of vasculitis associated with various neurological manifestations. Multiple components, including thrombosis, embolism, stenosis, and vascular inflammation, are involved in the underlying pathophysiology. Case Presentation: A 21-year-old male patient presented with vomiting, difficulty speaking, disorientation, and seizures. On examination, pinpoint pupils and blood pressure discrepancies among four limbs were noted.