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Journal of Experimental Neurology
ISSN: 2692-2819
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).
J Exp Neurol, 2022, Volume 3, Issue 3, p63-70 | DOI: 10.33696/Neurol.3.064Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine
Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury.
J Exp Neurol, 2022, Volume 3, Issue 3, p71-74 | DOI:The Jalisco Mutation: Familiar Alzheimer’s Disease in México
Before the age of 65, people with mutations in the genes for Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and the amyloid precursor protein (APP) experience familial Alzheimer’s disease (FAD). The sporadic type of Alzheimer’s disease (AD) is multifactorial and associated with the Apolipoprotein E ε4 allele (APOE ε4), which can up to 12 times increase the risk of getting the condition
J Exp Neurol, 2022, Volume 3, Issue 3, p75-77 | DOI:An Updated Overview of Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common form of dementia. Patients diagnosed with AD experience disordered cognition and memory, as well as changes in behaviour and personality. The vast majority of AD is diagnosed in patients aged over 65 years and classified as late onset (LOAD), with the remaining ~1% of cases termed early onset AD (EOAD).
J Exp Neurol, 2022, Volume 3, Issue 3, p78-81 | DOI:Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.