Journal of Experimental Neurology

Mini Review Open Access

Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex

Makiko Koike-Kumagai , Mari Wataya-Kaneda

Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome characterized by systemic hamartomas, including skin and neural symptoms. Many patients exhibit epilepsy, intellectual disability, autism, and other behavioral and neuropsychiatric symptoms, referred to as TSCassociated neuropsychiatric disorders (TAND).

J Exp Neurol, 2022, Volume 3, Issue 3, p63-70 | DOI: 10.33696/Neurol.3.064

Commentary Open Access

Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine

Yusuf Mehkri , Maxwell G. Woolridge , Brandon Lucke-Wold

Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury.

J Exp Neurol, 2022, Volume 3, Issue 3, p71-74 | DOI:

Editorial Open Access

The Jalisco Mutation: Familiar Alzheimer’s Disease in México

Marco Antonio Meraz-Ríos , Erika Alejandra Cabrera-Reyes , Mayte Lizeth Padilla-Cristerna

Before the age of 65, people with mutations in the genes for Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), and the amyloid precursor protein (APP) experience familial Alzheimer’s disease (FAD). The sporadic type of Alzheimer’s disease (AD) is multifactorial and associated with the Apolipoprotein E ε4 allele (APOE ε4), which can up to 12 times increase the risk of getting the condition

J Exp Neurol, 2022, Volume 3, Issue 3, p75-77 | DOI:

Editorial Open Access

An Updated Overview of Alzheimer’s Disease

Emmanuel Prikas

Alzheimer’s Disease (AD) is the most common form of dementia. Patients diagnosed with AD experience disordered cognition and memory, as well as changes in behaviour and personality. The vast majority of AD is diagnosed in patients aged over 65 years and classified as late onset (LOAD), with the remaining ~1% of cases termed early onset AD (EOAD).

J Exp Neurol, 2022, Volume 3, Issue 3, p78-81 | DOI: