A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that arises in the ventral pons during middle childhood.J Exp Neurol, 2020, Volume 1, Issue 4, p158-167 | DOI: 10.33696//Neurol.1.025
Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) are debilitating conditions that are highly associated with aging populations, especially those with comorbidities such as diabetes and hypertension.J Exp Neurol, 2021, Volume 2, Issue 4, p149-153 | DOI: 10.33696/Neurol.2.048
Differential Fecal Microbiome Dysbiosis after Equivalent Traumatic Brain Injury in Aged Versus Young Adult Mice
Traumatic brain injury (TBI) has a bimodal age distribution with peak incidence at age 24 and age 65 with worse outcomes developing in aged populationsJ Exp Neurol, 2021, Volume 2, Issue 3, p120-130 | DOI: 10.33696/Neurol.2.044
Experimental and hereditary defects in the ubiquitous scaffolding proteins of the spectrin gene family cause an array of neuropathologiesJ Exp Neurol, 2021, Volume 2, Issue 3, p131-139 | DOI: 10.33696/Neurol.2.045
Due to use as human vaccines and therapies, the clostridial neurotoxins (CNTs) have been subjected to decades of scientific investigation using biophysical, electrophysiological, and pharmacological approaches to establish mechanisms of toxin action.J Exp Neurol, 2020, Volume 1, Issue 4, p123-134 | DOI: 10.33696/Neurol.1.020
Human embryogenesis and the development of its most unique product, the human brain, are believed to be precisely regulated by factors adopted during human
evolution that differentiate us from other species.
Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tauJ Exp Neurol, 2021, Volume 2, Issue 1, p10-15 | DOI: 10.33696/Neurol.2.029
Anorexia nervosa (AN) is an eating disorder characterized by a fear of gaining weight and self-starvation, leading to life-threatening weight loss . It occurs predominately in women and frequently begins during adolescence.J Exp Neurol, 2021, Volume 2, Issue 1, p21-28 | DOI: 10.33696/Neurol.2.031
Uromodulin (UMOD) is a glycoprotein expressed by the epithelial cells of the thick ascending limb of Henle’s loop in the kidney. Research has shown that increased uromodulin expression may be associated with lower risk of cardiovascular disease in adults.J Exp Neurol, 2021, Volume 2, Issue 1, p29-33 | DOI: 10.33696/Neurol.2.032
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
Dravet syndrome (DS) is an intractable childhood epilepsy disorder affecting one in 15,000 to 20,000 births . It is caused by de novo heterozygous lossof- function mutations in the SCN1A gene encoding the brain type-I voltage-gated sodium channel Nav1.1J Exp Neurol, 2021, Volume 2, Issue 2, p81-85 | DOI: 10.33696/Neurol.2.040
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