Journal of Clinical Cardiology

Commentary Open Access

Coronary Revascularization in the Era of Transcatheter Aortic Valve Replacement: Treat the Patient, Manage the Disease

Pradyumna E Tummala , Cindy L Grines

Coronary artery disease continues to be the greatest cause of global mortality. The prevalence of coronary artery disease in patients with severe aortic stenosis varies widely, from 80% in extreme high-risk trials to only 15% in more recent low risk trials.

Mini Review Open Access

Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease

Jing Mu , Ming-Hui Zou

Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.

Short Communication Open Access

Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?

Edimar Alcides Bocchi , Deborah de Sá Pereira Belfort , Monica Samuel Avila

Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.

Commentary Open Access

The Value of the Left Atrial Appendage Orifice Perimeter of 3D Model Based on 3D TEE Data in the Choice of Device Size of LAmbre™ Occluder

Dan Jia , Qing Zhou , Hong-Ning Song , Lan Zhang , Sheng Cao , Bo Hu , Jin-ling Chen , Yu Liu , Bin Kong

Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.

Short Communication Open Access

Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis

So Yeon Kim , Raymond Comenzo , Amanda R. Vest , Nauman Saleem Siddiqui , Cindy Varga

Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee

Editorial Open Access

Hypertrophic Cardiomyopathy and the Troponins: The Enigma Remains

Rameen Shakur

Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.

Review Open Access

Lipoprotein Apheresis: First FDA Indicated Treatment for Elevated Lipoprotein(a)

Anne K. Nugent , Jessica V. Gray , Lauryn K. Gorby , Patrick M. Moriarty

Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).