Journal of Clinical Cardiology

Case Report Open Access

Ticagrelor-Associated Central Sleep Apnea: A Case Report and Review of the Literature

Danny Sameh Darwich , Sagger Mawri

Ticagrelor is an oral, third-generation reversible P2Y12 receptor antagonist used in the treatment of patients with atherosclerotic cardiovascular disease. Dyspnea is a well-recognized side effect of ticagrelor, typically occurring within hours to days after initiation. In most cases, the dyspnea is mild and resolves spontaneously without intervention. However, dyspnea can be significant and intolerable in some patients necessitating discontinuation of ticagrelor.

Original Research Open Access

CT Coronary Angiography Vs Cardiac Catheterization and Risk of Acute Kidney Injury – Comparative Study

Swatam Jain , Farzad Majidi

CT coronary angiography (CTCA) and invasive coronary angiography (ICA) are widely used to evaluate coronary artery disease (CAD). Both involve iodinated contrast, which may cause contrast-induced acute kidney injury (CI-AKI), particularly in high-risk patients. This study compared the incidence of AKI following CTCA versus ICA in hospitalized patients with symptomatic CAD.

Original Research Open Access

Coronary CT Angiography and Assessment of Coronary In-Stent Restenosis—A Brief Report of Stent-Related Factors among Positive Angiographic Cases

Ramin Khameneh Bagheri , Mahdi Radfar , Hassan Mehrad-Majd , Ali Heydari Bakavoli

In-stent restenosis (ISR) remains a significant concern in coronary artery disease management. This study aims to evaluate the efficacy of coronary computed tomography angiography (CCTA) in detecting ISR and to identify stent-related factors in a real-world patient population.

Original Research Open Access

Utilization of Prognostic Protein Tests in the Investigation of Suspected Chronic Coronary Artery Disease

Stephen A Williams , Jessica Chadwick , David Astling , Michael Hinterberg , Rachel Ostroff , Klara Rumora , Medina Durmo , Joan E Walter , Christian Mueller

Guidelines-driven diagnostic investigations for suspicion of functionally relevant coronary artery disease (fCAD) are complex and expensive. Therefore, we evaluated whether a previously validated proteomic residual cardiovascular risk (RCVR) model could complement existing fCAD detection strategies by accurately identifying patients at high risk for an event and safely ruling out fCAD in low-risk patients.

Case Report Open Access

Recurrent Prosthetic Valve Endocarditis Causing Pseudoaneurysm of the Mitral-aortic Intervalvular Fibrosa

Kenney Abraham , Matthew Pelletier , Ryan Heslin

Infective endocarditis (IE) refers to inflammation of the endocardium, which is the inner layer of the heart. One of the most significant risk factors for developing IE is bioprosthetic valves within the heart. IE can lead to formation of vegetations on the surfaces of heart valves, making treatment difficult with antibiotics alone, often requiring surgery.

Original Research Open Access

In-hospital Mortality Trends Across the Pre-pandemic, Pandemic, and Post-pandemic Eras in Cardiovascular and Cerebrovascular Conditions: A Retrospective Cohort Study

Swatam Jain , Pinak Shah , Alfred Danielian , Boone Singtong , Christopher Aboujaoude , Zade Zahlan , Rakahn Haddadin , Kush Kapadia

The COVID-19 pandemic strained healthcare delivery, but its lasting impact on acute and chronic cardiovascular and cerebrovascular mortality remains unclear. We compared in-hospital mortality for ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), ischemic stroke, and congestive heart failure (CHF) across pre-pandemic, pandemic, and post-pandemic eras.