Journal of Clinical Cardiology

Research Article Open Access

Late ECG Changes after Cisplatin-Based Chemotherapy in Testicular Cancer Survivors

Ljuba Bacharova , Andreas Thaler , Lucia Petrikova , Beata Mladosievicova , Daniela Svetlovska , Katarina Kalavska , Zora Krivosikova , Jozef Mardiak , Michal Mego , Michal Chovanec

Introducing cisplatin-based therapy into testicular cancer treatment represents a substantial progress in therapy leading to a longer survival of patients and less adverse effects; currently it represents the standard therapy.

Review Open Access

The Novel Antiplatelet Agent Revacept in Cardiovascular Medicine: The Promise of Efficacy Without Bleeding

Annalisa Contursi , Patrizia Ballerini , Sara Alberti , Götz Münch , Paola Patrignani

Revacept, a dimeric fusion protein of the extracellular domain of GPVI and the human Fc-fragment, inhibits collagen-mediated platelet adhesion and subsequent aggregation at the site of vascular injury. Finally, the possible utility of this pharmacological approach in the prevention of tumor metastasis is discussed.

Commentary Open Access

Should we Target Myostatin, PCSK9 or Their Combination in Ischemia or Reperfusion Injury?

Chiara Barisione , Domenico Palombo

Ischemia/reperfusion (I/R) injury is the consequence of a transient interruption of the blood supply for pathologic, traumatic or surgical reasons, followed by flow restoration with rapid hemodynamic changes in the downstream tissues and organs.

Commentary Open Access

COVID-19 Delays Presentation and Management of Acute Coronary Syndrome

Michael Y. Henein , Matteo Cameli , Maria Concetta Pastore , Giulia Elena Mandoli

The COVID-19 pandemic started at the end of 2019 and remains carrying a health threat and significant economic consequences. Over the last two years, COVID-19 has been the main Public Health issue, and has impacted regular healthcare systems, with significant build-up of waiting lists and delay in optimum management of other serious medical conditions including heart diseases and cancer.

Commentary Open Access

Commentary on: Echocardiography in Pulmonary Arterial Hypertension: Is It Time to Reconsider Its Prognostic Utility?

Eftychia Demerouti , Dimitrios Tsiapras

Pulmonary Arterial Hypertension (PAH) represents a rare but devastating disease due to small pulmonary arterial vessels remodelling and increased pulmonary vascular resistance leading to right ventricular dysfunction, right heart failure and death.