Loading
Volume 5, Issue 2, p45-108
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
A Case of Purulent Pericarditis in the Setting of Streptococcal Pneumonia
Purulent pericarditis was a prevalent complication of streptococcal pneumonia prior to the antibiotic era. In this article, we report a 68-yearold male presenting with dyspnea, chest pain, left knee pain, diagnosed with S. pneumoniae bacteremia and septic arthritis with isolation of same pathogen from synovial fluid.
J Clin Cardiol, 2024, Volume 5, Issue 2, p45-48 | DOI: 10.33696/cardiology.5.052Metabolic Syndrome and Risk of Early Heart Failure Rehospitalization in Older Adults: A Sex-Specific Analysis and Update
Metabolic syndrome (MetS) and heart failure (HF) remain important global health issues affecting young and older adults, independently contributing to HF hospitalizations and early rehospitalizations. Understanding sex-specific differences in HF research and accurately identifying risk of rehospitalization in patients with HF remains important for clinical decision making and management. We recently conducted a literature review and retrospective analysis of data specifically focusing on predictors of the 31 to 60-day HF rehospitalization timeframe among older women, as well as derivation of a conceptual model.
J Clin Cardiol, 2024, Volume 5, Issue 2, p49-53 | DOI: 10.33696/cardiology.5.053A Case of Ruptured Sinus of Valsalva Aneurysm
Introduction: Sinus of Valsalva aneurysm (SVA) is an abnormal dilation of one or more aortic sinuses located between the aortic valve annulus and the sinotubular junction. SVA rupture can cause shunting into cardiac chambers creating hemodynamic compromise and has a high morbidity and mortality requiring prompt recognition and treatment.
J Clin Cardiol, 2024, Volume 5, Issue 2, p54-58 | DOI: 10.33696/cardiology.5.054Investigating the Hormetic Role of Resolvin D2 in Atherosclerotic Cardiovascular Disease: Pathways to Biomarker Recognition for Resolvins?
Introduction: Resolvin D2 (RvD2), a mediator that helps resolve inflammation, plays a role in stopping the progression of atherosclerotic cardiovascular disease (ASCVD). Understanding how RvD2 levels relate to ASCVD risk could reveal its potential as both a treatment target and a biomarker. Methods: We examined the research by Liu et al., which used an analytical method that combined restricted cubic splines with multivariable Cox proportional hazard models.
J Clin Cardiol, 2024, Volume 5, Issue 2, p59-64 | DOI: 10.33696/cardiology.5.055Troponin: Think Before Testing
This is a high-value care-based quality improvement project that was carried out to decrease inappropriate troponin testing in the emergency department (ED) of a tertiary health institution in the United States with the goal of promoting evidence-based practices, minimizing waste, and enhancing the quality of care.
J Clin Cardiol, 2024, Volume 5, Issue 2, p65-72 | DOI: 10.33696/cardiology.5.056External Validation of Four Cardiovascular Risk Prediction Models
Background and Purpose: Cardiovascular disease (CVD) is a leading cause of death and disability in the world. Many CVD risk prediction models have been created, but those most widely used in clinical settings have not been externally validated, a significant gap addressed herein. Methods: Using the Multi-Ethnic Study of Atherosclerosis (MESA), we have externally validated the Framingham Risk Score, ASSIGN (Assessing the cardiovascular disease risk using SIGN) risk score, Atherosclerotic Cardiovascular Disease (ASCVD) risk score, and the European SCORE model, which were selected based on popularity among clinicians and frequency of clinical use.
J Clin Cardiol, 2024, Volume 5, Issue 2, p73-80 | DOI: 10.33696/cardiology.5.057The Night Sweats and Pulmonary Embolism-controversial Presentation and Differentiation
Pulmonary embolism (PE) is a common and potentially fatal condition where early and accurate diagnosis can significantly reduce mortality and morbidity. It typically presents with a range of associated symptoms such as breathlessness at rest or during exertion, coughing, discomfort or swelling in the legs, and wheezing. However, many atypical symptoms are also possible, including epigastric pain, hypotension, and night sweats, with mechanisms not yet understood.
J Clin Cardiol, 2024, Volume 5, Issue 2, p81-84 | DOI: 10.33696/cardiology.5.058Ethical Pearls in Fetal and Neonatal Cardiology
Working in health care institutions- deal with fetal/pediatric congenital heart diseases-build up moral sensitivity at different levels. Patient-family and doctor relationship starts from the moment family decides to seek medical/surgical advice. Parents ask everywhere to choose the best compassionate expert who could help at all levels. Mutual respect and trust are the first ethical values to launch the medical/surgical journey.
J Clin Cardiol, 2024, Volume 5, Issue 2, p85-87 | DOI: 10.33696/cardiology.5.059Commentary on Management of Respiratory Problems in Pediatric Cardiac Patients
Asthma, as a comorbidity in the presence of cardiac disorder, can be a very annoying issue. In contrast to the patient's cardiac disease, it might not feel like a major problem, especially when considering some cyanotic heart conditions, but in reality, having a daily cough can be very concerning for families, affecting their kid’s quality of life, sleep, and daily activity.
J Clin Cardiol, 2024, Volume 5, Issue 2, p103-108 | DOI: 10.33696/cardiology.5.061Chest Pain in Repeated Emergency Department Visitors
Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits and is also one of the major reasons of repeated ED visits, causing around 6% of these cases [1]. Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause.
Lipoprotein Apheresis: First FDA Indicated Treatment for Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).
Paradoxical Low Flow Aortic Stenosis: A Clinical Dilemma
Internists as well as cardiologists often receive echocardiogram reports which failed to offer a clear definition of the aortic stenosis (AS) severity due to discordant data regarding the aortic valve gradients and the valve area. Sometimes AS appears severe according to the valve area criteria, in spite of the fact that gradients across the valve are not in the severe range.
Acute Success and Long-term Follow-up of Catheter Ablation of Isthmus-dependent Atrial Flutter; A Comparison of 10 mm Tip Standard, 6 mm Tip Irrigated Radiofrequency, and Cryotherapy Catheters
Various catheter ablation technologies have evolved to improve the procedural success and safety of cavotricuspid isthmus (CTI) block. Numerous studies have compared the different energy types, catheter tip sizes, and energy settings.
A View on the Contribution of Hedgehog Signalling to Ventricular Septal Development
The ventricular septal defect (VSD) is the most frequent congenital heart disease in humans. It is defined as an opening in the septum separating the left and the right ventricle. This gap results in a mixture of oxygenated and deoxygenated blood and in an enhanced blood flow towards the lung and the left ventricle, a condition that leads to severe diseases such as left ventricular hypertrophy as well as pulmonary edema and dilatation.
Hypertrophic Cardiomyopathy and the Troponins: The Enigma Remains
Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.
Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee
Mono- and Multi-nucleated Cardiomyocytes Do Not Constitute Transcriptionally Distinct Entities
The last years have witnessed an increased interest in the genetic, epigenetic and transcriptional heterogeneity of mammalian hearts under basal and disease conditions. Although it is known for a long time that the heart consists of several, functionally different cell populations, more detailed insights into the potential heterogeneity of individual cell populations, such as cardiomyocytes, endothelial cells or fibroblasts were hindered by the lack of appropriate techniques.
Commentary on: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound Beta 1- Adrenergic Receptor
G protein coupled receptors (GPCRs) comprise a large superfamily of transmembrane proteins containing more than 800 unique family members. Critically, GPCRs mediate most of the cell responses to extracellular stimuli including hormones, neurotransmitters, light, taste, etc.
Predicting COVID-19 Hospitalized Patients’ Outcome with Homocysteine
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Beneficial Effects of Surgical Closure of Atrial Septal Defect Outweigh Potential Complications in Sick Infants
Atrial septal defect (ASD) is a common congenital heart disease diagnosed during childhood. Persistently increased pulmonary blood flow and dilated right atrium (RA) and right ventricle (RV) result in multiple symptoms and morbidities in adulthood; untreated adults may develop exercise intolerance, congestive heart failure, atrial tachyarrhythmias, pulmonary hypertension (PH), embolic stroke, or even death.
Cardiac Stem Cell Therapy, Quo Vadis
Cardiovascular disease causes 30% of global mortality and is still the number one cause of death worldwide. A main patho-physiological process is the coronary disease leading to malperfusion and ischemic cardiac disease as well as cardiac infarction.
Percutaneous Treatment of Mitral Valve Regurgitation: An Evolving Field
In the past two decades great interest has developed for less-invasive, percutaneous mitral valve (MV) repair strategies. This is mainly due to the increasing number of elderly patients with comorbidities and/or patients with left ventricular (LV) dysfunction, that are associated with a high surgical risk.
Blood Pressure Lowering May Decrease Cognitive Decline; But Are We Ready to Lower Blood Pressure in the Real World?
Dementia and hypertension are highly prevalent, epidemiologically related chronic conditions disproportionately affecting older persons; approximately 97% of persons with dementia and 66% with hypertension are over the age of 65.
The Value of the Left Atrial Appendage Orifice Perimeter of 3D Model Based on 3D TEE Data in the Choice of Device Size of LAmbre™ Occluder
Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.
Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19
After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19.
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?
Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.
Asystole during Tilt Testing-Induced Syncope: A Long-Term Follow-Up
The vasovagal (VV) syncope, a variant of neurally mediated reflex syncopal syndromes is a common clinical entity and is one of a heterogeneous group of disorders of orthostatic intolerance that can be identified during an upright tilt table (TT) test. The clinical response to this test is varied, with a majority of the patients exhibiting a mixed response (vasodepressor-cardioinhibitory) and the remainder either a vasodepressor or cardioinhibitory predominant response depending on the relative d
Thyroid Hormones in Dilated Cardiomyopathy: Is It a Promising Therapeutic Option?
Dilated cardiomyopathy (DCM) is chronic heart muscle disease characterized by progressive ventricular enlargement and contractile dysfunction involving either left or both ventricles. It is considered one of the leading causes of heart failure with reduced ejection fraction (HFrEF) worldwide
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease
Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.