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Volume 7, Issue 1, p1-78
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Left Atrial Appendage Closure Patients with Same Day Discharge Versus Non-same Day Discharge: Demographics and Outcome Comparisons
Currently, newer strategies are being implemented regarding WATCHMAN placement in the community hospital, such as same-day discharge (SDD). The safety of this protocol needs to be further assessed. The study aimed to evaluate the outcomes of SDD versus non-SDD in patients with nonvalvular atrial fibrillation who underwent WATCHMAN placement by comparing baseline demographics and post-procedure outcomes.
J Clin Cardiol, 2026, Volume 7, Issue 1, p1-8 | DOI: 10.33696/cardiology.7.085
Cardiac Remodeling Post-myocardial Infarction: Novel Therapies—Narrative Review
Myocardial infarction (MI) leads to progressive left ventricular (LV) remodeling, significantly affecting patient outcomes and prognosis. This paper provides a critical overview of the current standard of care and emerging pharmacological and regenerative therapies for prevention of cardiac remodeling post-MI.
J Clin Cardiol, 2026, Volume 7, Issue 1, p9-33 | DOI: 10.33696/cardiology.7.086
Relationship Between Fluid Responsiveness and Outcome of Patients with Acute Heart Failure Reduced Ejection Fraction
Higher left ventricular filling pressure (LVFP) is often associated with non-fluid responsiveness in heart failure patients, particularly those with reduced ejection fraction. This hemodynamic state has been linked to adverse outcomes, including higher rates of rehospitalization and mortality. However, the prognostic implications of fluid responsiveness assessed after decongestion remain uncertain.
J Clin Cardiol, 2026, Volume 7, Issue 1, p34-44 | DOI: 10.33696/cardiology.7.087
Clinical Safety and Procedural Performance of the Optima SC Semi-compliant Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in Coronary Intervention: A Multicenter Post-Market Study
Semi-compliant (SC) balloons are essential in PCI for lesion preparation before stent deployment. The Optima SC PTCA balloon catheter, a next-generation device, was evaluated in this post-marketing, multicenter study to assess its real-world performance and safety.
J Clin Cardiol, 2026, Volume 7, Issue 1, p45-50 | DOI: 10.33696/cardiology.7.088
Association of Subretinal Drusenoid Deposits in Age-Related Macular Degeneration with Decreased Cardiac Performance and Systemic Perfusion in Severe Aortic Stenosis
Subretinal drusenoid deposits (SDDs), a hallmark of age-related macular degeneration (AMD), have been linked to cardiovascular disease, but the underlying mechanism remains unclear. We investigated the association between SDDs and severe aortic stenosis (AS).
J Clin Cardiol, 2026, Volume 7, Issue 1, p51-57 | DOI: 10.33696/cardiology.7.089
Ratio Variables in Regression: Implications for Cardiovascular Research
Ratio variables, such as body mass index (BMI) and left ventricular ejection fraction (LVEF), are deeply ingrained in cardiovascular research and practice, yet the use of ratios in regression models can confuse associations and obscure underlying mechanisms.
J Clin Cardiol, 2026, Volume 7, Issue 1, p58-61 | DOI: 10.33696/cardiology.7.090
Outcomes of Transcatheter Aortic Valve Replacement Performed Within 90 Days after Acute Myocardial Infarction: A Nationwide Retrospective Analysis
Transcatheter aortic valve replacement (TAVR) is currently the most commonly utilized management strategy for severe aortic stenosis. The short-term outcomes of TAVR in patients who experienced a recent acute myocardial infarction (AMI) remain unclear.
J Clin Cardiol, 2026, Volume 7, Issue 1, p62-68 | DOI: 10.33696/cardiology.7.091
Plasma Donation Inducing Acute ST-Elevation Myocardial Infarction: A Case Report
Plasma donation is generally considered a safe procedure, and most reported adverse events are related to venipuncture or transient volume loss. Arterial thrombotic events, including acute myocardial infarction, are exceedingly rare but have been described after source plasma donation performed by plasmapheresis.
J Clin Cardiol, 2026, Volume 7, Issue 1, p69-73 | DOI: 10.33696/cardiology.7.092
Communal Coping with Heart Failure: Commentary on Marital Quality and Patient Survival
Earlier Am J Cardiol papers reported that a composite measure of marital quality predicted heart failure (HF) survival over follow-up intervals of 3 and 8 years after adjusting for baseline illness severity (NYHA class).
J Clin Cardiol, 2026, Volume 7, Issue 1, p74-78 | DOI: 10.33696/cardiology.7.093
Chest Pain in Repeated Emergency Department Visitors
Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits and is also one of the major reasons of repeated ED visits, causing around 6% of these cases [1]. Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause.
Lipoprotein Apheresis: First FDA Indicated Treatment for Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).
Paradoxical Low Flow Aortic Stenosis: A Clinical Dilemma
Internists as well as cardiologists often receive echocardiogram reports which failed to offer a clear definition of the aortic stenosis (AS) severity due to discordant data regarding the aortic valve gradients and the valve area. Sometimes AS appears severe according to the valve area criteria, in spite of the fact that gradients across the valve are not in the severe range.
Acute Success and Long-term Follow-up of Catheter Ablation of Isthmus-dependent Atrial Flutter; A Comparison of 10 mm Tip Standard, 6 mm Tip Irrigated Radiofrequency, and Cryotherapy Catheters
Various catheter ablation technologies have evolved to improve the procedural success and safety of cavotricuspid isthmus (CTI) block. Numerous studies have compared the different energy types, catheter tip sizes, and energy settings.
A View on the Contribution of Hedgehog Signalling to Ventricular Septal Development
The ventricular septal defect (VSD) is the most frequent congenital heart disease in humans. It is defined as an opening in the septum separating the left and the right ventricle. This gap results in a mixture of oxygenated and deoxygenated blood and in an enhanced blood flow towards the lung and the left ventricle, a condition that leads to severe diseases such as left ventricular hypertrophy as well as pulmonary edema and dilatation.
Hypertrophic Cardiomyopathy and the Troponins: The Enigma Remains
Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.
Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee
Mono- and Multi-nucleated Cardiomyocytes Do Not Constitute Transcriptionally Distinct Entities
The last years have witnessed an increased interest in the genetic, epigenetic and transcriptional heterogeneity of mammalian hearts under basal and disease conditions. Although it is known for a long time that the heart consists of several, functionally different cell populations, more detailed insights into the potential heterogeneity of individual cell populations, such as cardiomyocytes, endothelial cells or fibroblasts were hindered by the lack of appropriate techniques.
Commentary on: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound Beta 1- Adrenergic Receptor
G protein coupled receptors (GPCRs) comprise a large superfamily of transmembrane proteins containing more than 800 unique family members. Critically, GPCRs mediate most of the cell responses to extracellular stimuli including hormones, neurotransmitters, light, taste, etc.
Predicting COVID-19 Hospitalized Patients’ Outcome with Homocysteine
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Beneficial Effects of Surgical Closure of Atrial Septal Defect Outweigh Potential Complications in Sick Infants
Atrial septal defect (ASD) is a common congenital heart disease diagnosed during childhood. Persistently increased pulmonary blood flow and dilated right atrium (RA) and right ventricle (RV) result in multiple symptoms and morbidities in adulthood; untreated adults may develop exercise intolerance, congestive heart failure, atrial tachyarrhythmias, pulmonary hypertension (PH), embolic stroke, or even death.
Cardiac Stem Cell Therapy, Quo Vadis
Cardiovascular disease causes 30% of global mortality and is still the number one cause of death worldwide. A main patho-physiological process is the coronary disease leading to malperfusion and ischemic cardiac disease as well as cardiac infarction.
Percutaneous Treatment of Mitral Valve Regurgitation: An Evolving Field
In the past two decades great interest has developed for less-invasive, percutaneous mitral valve (MV) repair strategies. This is mainly due to the increasing number of elderly patients with comorbidities and/or patients with left ventricular (LV) dysfunction, that are associated with a high surgical risk.
Blood Pressure Lowering May Decrease Cognitive Decline; But Are We Ready to Lower Blood Pressure in the Real World?
Dementia and hypertension are highly prevalent, epidemiologically related chronic conditions disproportionately affecting older persons; approximately 97% of persons with dementia and 66% with hypertension are over the age of 65.
The Value of the Left Atrial Appendage Orifice Perimeter of 3D Model Based on 3D TEE Data in the Choice of Device Size of LAmbre™ Occluder
Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.
Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19
After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19.
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?
Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.
Asystole during Tilt Testing-Induced Syncope: A Long-Term Follow-Up
The vasovagal (VV) syncope, a variant of neurally mediated reflex syncopal syndromes is a common clinical entity and is one of a heterogeneous group of disorders of orthostatic intolerance that can be identified during an upright tilt table (TT) test. The clinical response to this test is varied, with a majority of the patients exhibiting a mixed response (vasodepressor-cardioinhibitory) and the remainder either a vasodepressor or cardioinhibitory predominant response depending on the relative d
Thyroid Hormones in Dilated Cardiomyopathy: Is It a Promising Therapeutic Option?
Dilated cardiomyopathy (DCM) is chronic heart muscle disease characterized by progressive ventricular enlargement and contractile dysfunction involving either left or both ventricles. It is considered one of the leading causes of heart failure with reduced ejection fraction (HFrEF) worldwide
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease
Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.