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Journal of Cellular Signaling
ISSN: 2692-0638
The Outcome of Tumor Ablation Therapies is Determined by Stress Signaling Networks
Increasingly prominent roles in interventional oncology are held by various tumor ablation therapies performed by direct applications of local acute trauma-inducing insult to the targeted lesion aiming for its rapid in situ destruction. These therapies include treatments based on various forms of thermal energy delivery (photothermal, cryoablation, microwave ablation, radiofrequency ablation), non-thermal illumination (photodynamic therapy), electric field exposure, or high hydrostatic pressure
J Cell Signal, 2022, Volume 3, Issue 1, p1-4 | DOI: 10.33696/Signaling.3.062Novel Treatments Targeting the Dysregulated Cell Signaling Pathway during Sepsis
Previously characterized as a purely immune mediated disease, sepsis is now recognized as a dysregulated multisystem response against a pathogen. Recognition of the infectious agent by pathogen recognition receptors (PRRs) can initiate activation of the NF-κB signaling pathway and promote the secretion of proinflammatory cytokines. During sepsis, the activation of NF-κB is dysregulated and results in cytokine storm, or the pathologic release of cytokines.
J Cell Signal, 2021, Volume 2, Issue 4, p228-234 | DOI: 10.33696/Signaling.2.055Plasminogen Activator Inhibitor-1 and Oncogenesis in the Liver Disease
Hepatocellular carcinoma (HCC) is a significant cause of cancer mortality worldwide. Chronic hepatic inflammation and fibrosis play a critical role in the development of HCC. Liver fibrosis develops as a result of response to injury such that a persistent and excessive wound healing response induces extracellular matrix (ECM) deposition leading to HCC.
J Cell Signal, 2021, Volume 2, Issue 3, p221-227 | DOI: 10.33696/Signaling.2.054Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation
The western diet and overuse of anti-inflammatory medication have caused a great deal of stress on the liver. Obesity and the associated inflammatory state in insulin-responsive tissues result in the release of pro-inflammatory cytokine that activates the stress-responsive MAPKs, p38 MAPK, and JNK. These MAPKs have figured prominently as critical effectors in physiological and pathophysiological hepatic inflammation.
J Cell Signal, 2021, Volume 2, Issue 3, p172-180 | DOI: 10.33696/Signaling.2.049APE1/Ref-1 as a Novel Target for Retinal Diseases
APE1/Ref-1 (also called Ref-1) has been extensively studied for its role in DNA repair and reduction-oxidation (redox) signaling. The review titled: “The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease” by Caston et. al. summarizes the molecular functions of Ref-1 and the role it plays in a number of diseases, with a specific focus on various types of cancer.
J Cell Signal, 2021, Volume 2, Issue 2, p133-138 | DOI: 10.33696/Signaling.2.044Cancer-associated Molecular Abnormalities in Human NK cells
Cancer is one of the leading causes of death worldwide. The immune system plays an important role in all steps of cancer development, growth and spreading as was repeatedly proven in a variety of experimental and clinical studies. Among the immune cells, Natural Killer cells, or NK cells, are critical to the innate immunity as one of the key effector cells of cancer immunosurveillance.
J Cell Signal, 2021, Volume 2, Issue 2, p94-99 | DOI: 10.33696/Signaling.2.039Effects of a CB2 Subtype Selective Agonist ABK5-1 on Cytokine Production in Microglia
Neuroinflammation is closely associated with various diseases including neuropathic pain. Microglia are immune cells in the central nervous system which are the main players of immunity and inflammation. Since microglia are activated by nerve injury, and they produce proinflammatory mediators to cause neuropathic pain, targeting activated microglia is considered to be a strategy for treating neuropathic pain.
J Cell Signal, 2021, Volume 2, Issue 2, p85-93 | DOI: 10.33696/Signaling.2.038Possible Therapeutic Use of Natural Compounds Against COVID-19
The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to coronavirus disease-19 (COVID-19); a pandemic disease that has resulted in devastating social, economic, morbidity and mortality burdens. SARS-CoV-2 infects cells following receptor-mediated endocytosis and priming by cellular proteases.
J Cell Signal, 2021, Volume 2, Issue 1, p63-79 | DOI: 10.33696/Signaling.2.036The Possible Role of Molecular Vibration in Intracellular Signalling
The exchange of information within the cell is extremely complex. Besides the well-studied chemical signalling, physical signalling is required to fulfil spatial and temporal aspects. The Golgi apparatus and the microtubule skeleton system are the decisive structures for numerous intracellular transport tasks.
J Cell Signal, 2020, Volume 1, Issue 4, p180-186 | DOI: 10.33696/Signaling.1.027Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics
Nausea and vomiting are protective defense mechanisms by which vomit competent species avoid ingestion of potentially toxic substances. More specifically, vomiting is the act of forceful expulsion of gastrointestinal contents through the mouth, whereas nausea is an unpleasant painless subjective feeling that one will imminently vomit.
J Cell Signal, 2020, Volume 1, Issue 4, p155-159 | DOI: 10.33696/Signaling.1.024Dendorbium Nobile Lindl. Alkaloids Suppress NF-κB and NLRP3 Signaling Pathways to Attenuate Lipopolysaccharide-induced Neuroinflammation
The important immune cells in the brain are called microglia acting as the central junction between neuroinflammation and neurodegenerative diseases. In patients of cognitive disorders and Alzheimer’s disease (AD) animal models, amoebic morphology and inflammatory pathways are activated to release numerous cells in the inflammatory factors by active microglia.
J Cell Signal, 2020, Volume 1, Issue 4, p102-114 | DOI: 10.33696/Signaling.1.019Kv1.3 Potassium Channels: Promising Therapeutic Targets in Hematological Malignancies
Voltage-gated Kv1.3 potassium channels control the membrane potential, cellular activation and cell death. Kv1.3 channels have been extensively studied in autoimmune disorders and are promising drug targets for the treatment of solid cancer.
J Cell Signal, 2020, Volume 1, Issue 3, p79-86 | DOI: 10.33696/Signaling.1.016Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies
Observational studies have demonstrated association of metformin with reduced cancer incidence and mortality in multiple cancer types, including gastrointestinal (GI) malignancies. Anti-neoplastic effects of metformin are believed through many mechanisms including activation of AMP-activated protein kinase, which controls mammalian target of rapamycin (mTOR) growth regulatory pathway.
J Cell Signal, 2020, Volume 1, Issue 2, p35-41 | DOI: 10.33696/Signaling.1.008Manipulating Oxidative Stress Following Ionizing Radiation
It is now well accepted that the ionizing radiation-generated reactive oxygen species (ROS), that constitute ~2/3 of the effects of external beam radiation, do not only produce direct tumor cell death, but also affect the surrounding microenvironment. Moreover, this indirect effect of radiation may result in systemic effects, specifically the initiation of an inflammatory response.
J Cell Signal, 2020, Volume 1, Issue 1, p8-13 | DOI: 10.33696/Signaling.1.003Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.