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Journal of Cellular Immunology
ISSN: 2689-2812
2020
Volume 2, Issue 4, p143-200
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
CRISPR Taking the Front Seat in Immunotherapy
Saad S. Kenderian, Andrew D. Badley
CRISPR (clustered regularly interspaced short palindromic repeats) technology has dramatically simplified genome editing and is widely applicable in both basic research and therapeutic areas.
J Cell Immunol, 2020, Volume 2, Issue 4, p143-148 | DOI: 10.33696/immunology.2.032
Lung-targeted SERCA2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis
Malik Bisserier, Lahouaria Hadri
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, devastating, and rare lung disease. IPF is characterized by usual interstitial pneumonia and represents the most common idiopathic interstitial lung disease.
J Cell Immunol, 2020, Volume 2, Issue 4, p149-156 | DOI: 10.33696/immunology.2.033
TNF-alpha Inhibitors and Neutropenia: Current State of Art
Emmanuel Andrès, Noel Lorenzo Villalba, Abrar-Ahmad Zulfiqar, Yasmine Maouche, Khalid Serraj, Jacques-Eric Gottenberg
Drug-induced severe neutropenia, defined as an absolute neutrophil count (NC) ≤ 0.5 x 109/L or a complete lack of neutrophils in circulating blood, is a potentially severe complication that has been related to most classes of drugs. For the majority of drugs, the risk is likely to be very small.
J Cell Immunol, 2020, Volume 2, Issue 4, p157-164 | DOI: 10.33696/immunology.2.034
Autoantibodies in Overlapping Systemic Sclerosis and Primary Biliary Cirrhosis Autoimmune Diseases
Manuel M. Valdivia
Anticentromere antibodies (ACA) are considered an important diagnostic marker of scleroderma or systemic sclerosis (SSc), being CENP-B the major centromere auto-antigen recognized by sera from SSc patients. However, ACA can also be detected in patients with other connective tissue diseases.
J Cell Immunol, 2020, Volume 2, Issue 4, p165-167 | DOI: 10.33696//immunology.2.035
Sex Differences in Clinical Characteristics and Platelet Activation in Respiratory Syncytial Virus Bronchiolitis
Isabella Tarissi De Jacobis, Rosa Vona, Elisabetta Straface, Lucrezia Gambardella, Giulia Ceglie, Francesca de Gennaro, Ilenia Pontini, Anna Chiara Vittucci, Alessandra Carè, Camilla Cittadini, Alberto Villani, Donatella Pietraforte
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis. It is a single-stranded RNA virus of the Paramyxoviridae family that is transmitted through nasopharyngeal or conjunctival mucosa from infected individuals. The incubation period ranges from 2 to 8 days.
J Cell Immunol, 2020, Volume 2, Issue 4, p168-170 | DOI: 10.33696/immunology.2.036
The status of Regulatory Cells/Molecules in Psoriatic Skin
Vadasz Zahava
In normal non-inflamed skin, the balance between the expression of pro-inflammatory cells/cytokines and regulatory/protective functions are extremely important for the maintenance of healthy skin. Normal skin T cells (mostly Th1 memory effector cells) have a remarkably diverse TCR repertoire and express high levels of CCR4, CCR6 and CCR8.
J Cell Immunol, 2020, Volume 2, Issue 4, p171-174 | DOI: 10.33696/immunology.2.037
Are Cysteine-lipases Involved in the Immune System?
Qi Wu, Manfred T. Reetz
Lipases, esterases and proteases constitute superfamilies of hydrolases not only play an important role in the immune system, but also as catalysts in biotechnology and organic chemistry. Mechanistically, they all involve a similar catalytic triad.
J Cell Immunol, 2020, Volume 2, Issue 4, p175-177 | DOI: 10.33696/immunology.2.038
Allicin as an Adjunct Immunotherapy against Tuberculosis
Samreen Fatima, Ved Prakash Dwivedi
Allicin (diallylthiosulfinate) is a volatile, oxygenated, sulphur-containing compound, extracted from garlic (Allium sativum). It is responsible for the characteristic odor of garlic. Allicin is known to exert its effects as an antipathogenic agent mainly by targeting the thiol-containing proteins or enzymes in different microorganisms and also by regulating the key genes responsible for the virulence of the microorganism.
J Cell Immunol, 2020, Volume 2, Issue 4, p178-182 | DOI: 10.33696/immunology.2.039
Cytokines (IL-1 β, IL-6, IL-18, TNF-α) in Blood and Cerebrospinal Fluid in Neonatal Hypoxia/Ischemia)
Darinka Šumanovi?-Glamuzina, Marjana Jerkovi?-Raguž
Perinatal brain injury is an important clinical and socioeconomic entity. It is a syndrome of impaired brain function in the early days of life, and it is a consequence of inadequate brain oxygenation before, during or shortly after birth, with high mortality rates and early and late morbidity rates.
J Cell Immunol, 2020, Volume 2, Issue 4, p183-187 | DOI: 10.33696/immunology.2.040
The Considerable Conundrum of NSAID-induced Melt
Basil Rigas, Wei Huang, Robert A. Honkanen
Over 20 years after the first description of NSAIDinduced Corneal Melt (NICM), a rare but potentially devastating visual complication induced by a topically applied medication, the optimal prevention and treatment for this condition remain unknown creating a clinical conundrum for eye care professionals and challenge for eye researchers.
J Cell Immunol, 2020, Volume 2, Issue 4, p188-191 | DOI: 10.33696/immunology.2.041
Current Advances in CAR T Cell Therapy for Malignant Mesothelioma
Astero Klampatsa, Steven M. Albelda
Malignant mesothelioma (MM) is an incurable primary tumor of the body’s serosal surfaces: the pleura, peritoneum, pericardium and the tunica vaginalis (in men).
J Cell Immunol, 2020, Volume 2, Issue 4, p192-200 | DOI: 10.33696/immunology.2.042