Journal of Cellular Immunology

2020

Volume 2, Issue 4, p143-200

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Commentary Open Access

CRISPR Taking the Front Seat in Immunotherapy

Saad S. Kenderian, Andrew D. Badley

CRISPR (clustered regularly interspaced short palindromic repeats) technology has dramatically simplified genome editing and is widely applicable in both basic research and therapeutic areas. The basic principle of CRISPR relies on the use of guide RNA which is designed to bind to the DNA sequence of interest along with a CRISPR-associated (Cas) endonuclease which introduces a double-stranded DNA break (DSB) at that site.

J Cell Immunol, 2020, Volume 2, Issue 4, p143-148 | DOI: 10.33696/immunology.2.032

Commentary Open Access

Lung-targeted SERCA_2a Gene Therapy: From Discovery to Therapeutic Application in Bleomycin-Induced Pulmonary Fibrosis

Malik Bisserier, Lahouaria Hadri

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by an accumulation of scar tissue within the lungs and the common presence of usual interstitial pneumonia. Unfortunately, only a few FDA-approved therapeutic options are currently available for the treatment of IPF and IPF remains associated with poor prognosis. Therefore, the identification of new pharmacological targets and strategies are critical for the treatment of IPF.

J Cell Immunol, 2020, Volume 2, Issue 4, p149-156 | DOI: 10.33696/immunology.2.033

Review Article Open Access

TNF-alpha Inhibitors and Neutropenia: Current State of Art

Emmanuel Andrès, Noel Lorenzo Villalba, Abrar-Ahmad Zulfiqar, Yasmine Maouche, Khalid Serraj, Jacques-Eric Gottenberg

To date, neutropenia and agranulocytosis related to TNF-α inhibitors have been discussed infrequently in the literature. In the current paper, a narrative review of the literature was performed on anti-TNF-α inhibitors, including infliximab, adalimumab, etanercept, golimumab, and certolizumab, using the PubMed database of the US National Library of Medicine. The review was restricted to autoimmune and auto-inflammatory diseases or other orphan diseases.

J Cell Immunol, 2020, Volume 2, Issue 4, p157-164 | DOI: 10.33696/immunology.2.034

Commentary Open Access

Autoantibodies in Overlapping Systemic Sclerosis and Primary Biliary Cirrhosis Autoimmune Diseases

Manuel M. Valdivia

Anticentromere antibodies (ACA) are considered an important diagnostic marker of scleroderma or systemic sclerosis (SSc), being CENP-B the major centromere auto-antigen recognized by sera from SSc patients. However, ACA can also be detected in patients with other connective tissue diseases. Significantly the prevalence of organ-specific antibodies in SSc patients is relatively high.

J Cell Immunol, 2020, Volume 2, Issue 4, p165-167 | DOI: 10.33696//immunology.2.035

Short Communication Open Access

Sex Differences in Clinical Characteristics and Platelet Activation in Respiratory Syncytial Virus Bronchiolitis

Isabella Tarissi De Jacobis, Rosa Vona, Elisabetta Straface, Lucrezia Gambardella, Giulia Ceglie, Francesca de Gennaro, Ilenia Pontini, Anna Chiara Vittucci, Alessandra Carè, Camilla Cittadini, Alberto Villani, Donatella Pietraforte

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis. It is a single-stranded RNA virus of the Paramyxoviridae family that is transmitted through nasopharyngeal or conjunctival mucosa from infected individuals. The incubation period ranges from 2 to 8 days. Two antigenically different RSV subtypes exist, A and B.

J Cell Immunol, 2020, Volume 2, Issue 4, p168-170 | DOI: 10.33696/immunology.2.036

Short Communication Open Access

The status of Regulatory Cells/Molecules in Psoriatic Skin

Vadasz Zahava

In normal non-inflamed skin, the balance between the expression of pro-inflammatory cells/cytokines and regulatory/protective functions are extremely important for the maintenance of healthy skin. Normal skin T cells (mostly Th1 memory effector cells) have a remarkably diverse TCR repertoire and express high levels of CCR4, CCR6 and CCR8.

J Cell Immunol, 2020, Volume 2, Issue 4, p171-174 | DOI: 10.33696/immunology.2.037

Commentary Open Access

Are Cysteine-lipases Involved in the Immune System?

Qi Wu, Manfred T. Reetz

Lipases, esterases and proteases constitute superfamilies of hydrolases not only play an important role in the immune system, but also as catalysts in biotechnology and organic chemistry. Mechanistically, they all involve a similar catalytic triad.

J Cell Immunol, 2020, Volume 2, Issue 4, p175-177 | DOI: 10.33696/immunology.2.038

Short Communication Open Access

Allicin as an Adjunct Immunotherapy against Tuberculosis

Samreen Fatima, Ved Prakash Dwivedi

Allicin (diallylthiosulfinate) is a volatile, oxygenated, sulphur-containing compound, extracted from garlic (Allium sativum). It is responsible for the characteristic odor of garlic. Allicin is known to exert its effects as an antipathogenic agent mainly by targeting the thiol-containing proteins or enzymes in different microorganisms and also by regulating the key genes responsible for the virulence of the microorganism.

J Cell Immunol, 2020, Volume 2, Issue 4, p178-182 | DOI: 10.33696/immunology.2.039

Short Communication Open Access

Cytokines (IL-1 β, IL-6, IL-18, TNF-α) in Blood and Cerebrospinal Fluid in Neonatal Hypoxia/Ischemia)

Darinka Šumanovi?-Glamuzina, Marjana Jerkovi?-Raguž

Perinatal brain injury is an important clinical and socioeconomic entity. It is a syndrome of impaired brain function in the early days of life, and it is a consequence of inadequate brain oxygenation before, during or shortly after birth, with high mortality rates and early and late morbidity rates.

J Cell Immunol, 2020, Volume 2, Issue 4, p183-187 | DOI: 10.33696/immunology.2.040

Commentary Open Access

The Considerable Conundrum of NSAID-induced Melt

Basil Rigas, Wei Huang, Robert A. Honkanen

Over 20 years after the first description of NSAIDinduced Corneal Melt (NICM), a rare but potentially devastating visual complication induced by a topically applied medication, the optimal prevention and treatment for this condition remain unknown creating a clinical conundrum for eye care professionals and challenge for eye researchers.

J Cell Immunol, 2020, Volume 2, Issue 4, p188-191 | DOI: 10.33696/immunology.2.041

Review Article Open Access

Current Advances in CAR T Cell Therapy for Malignant Mesothelioma

Astero Klampatsa, Steven M. Albelda

Malignant mesothelioma is a relatively rare malignancy arising in the body’s serosal surfaces, with malignant pleural mesothelioma (MPM) being the most common type. It is characterized by local spread within the thorax, poor prognosis and resistance to treatment. The development of various immunotherapeutic options has provided a new way- and hope- in treating cancer patients. Chimeric antigen receptor (CAR) T cell therapy has been proven very successful in treating hematological cancers, like leukemias and lymphomas, and its use is now being tested in solid tumors.

J Cell Immunol, 2020, Volume 2, Issue 4, p192-200 | DOI: 10.33696/immunology.2.042

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Journal of Cellular Immunology

2020

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