Volume 3, Issue 2, p33-65
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Making a Rationale Decision About -Uses of FFP: A Study at the Blood Bank of Tertiary Care Hospital of Southern Rajasthan
Blood is a crucial part of life as there is no other alternative to the human body’s connective tissue. Blood is composed of blood cells suspended in plasma. Plasma, which constitutes 55% of body fluid, is mostly water (92% by volume) and contains proteins, glucose, mineral ions, hormones, carbon dioxide, urea, uric acid, oxygen, etc. (plasma being the primary medium for excretory product transportation). Plasma performs many essential functions within the body, like coagulation, supply of nutrients, removal of wastesJ Clin Haematol, 2022, Volume 3, Issue 2, p33-38 | DOI: 10.33696/haematology.3.046
Acute myeloid leukemia (AML) is a type of hematological malignancies that originate from hematopoietic stem/ progenitor cells in myeloid lineage. The genetic heterogeneity of AML causes varied responses to the existing treatment options, as well as drug resistance and refractory/ recurrent, posing a challenge to personalized precision medicine. Therefore, it is urgent to identify novel molecular targets, discover patient specific and disease specific risk factors, and explore effective combinations of modalities and drugs in the foreseeable future.J Clin Haematol, 2022, Volume 3, Issue 2, p39-44 | DOI: 10.33696/haematology.3.047
B-cell Acute Lymphoblastic Leukemia with a Normal Platelet Count, Presenting as a Limp in a 2-year-old Child
Limping in children is a common complaint made at pediatric, pediatric orthopedic and in emergency departments. It is defined as a deviation from the normal gait pattern expected for the child’s age. Especially in young children, the ambiguities in the signs and symptoms necessitate extensive investigations to enable a reliable medical assessment for the etiological dilemma of limping.J Clin Haematol, 2022, Volume 3, Issue 2, p45-47 | DOI: 10.33696/haematology.3.048
Multiple Myeloma with Neutrophilia: Two Etiologic Pathways for a Rare Presentation of a Common Diagnosis
Multiple myeloma (MM) is a common hematologic malignancy, with 32,110 new cases diagnosed in the United States in 2019, resulting in 12,960 deaths. While neutrophilia
is also a common entity, it most often arises secondary to other etiologies, such as infection or inflammatory processes.
Concomitant Langerhans Cell Histiocytosis and Chronic Myelomonocytic Leukaemia Responding to 5-azacitidine
Langerhans cell histiocytosis (LCH) is a rare, clonal, haematological disease of myeloid origin involving infiltration of neoplastic cells resembling Langerhans cells in various tissues. LCH cells express normal Langerhans cell markers such as CD1a, Langerin (CD207), and S100.J Clin Haematol, 2022, Volume 3, Issue 2, p61-65 | DOI: 10.33696/haematology.3.050
Karyotypic Profile of Chronic Myeloid Leukemia in Patients Diagnosed at Tertiary Level in Afghanistan
Balanced translocation resulting in fusion of the Abelson gene (ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2 is the pathognomonic molecular driver of CML. The resulting BCRABL 1 fusion gene is both the diagnostic as well as therapeutic target of CML. The first agent with tyrosine kinase inhibitor activity that was licenced in 2000 for treatment of CML patients, was Imatinib, gradually followed by multiple agents with higher efficacy.
Bacterial communication via quorum sensing (QS) molecules, as well as toxin-antitoxin (TA) gene modules located on bacterial chromosomes are well-studied mechanisms. Escherichia coli mazEF is a stress-induced TA system mediating cell death requiring a QS extracellular death factor (EDF), the pentapeptide NNWNN. MazF is an endoribonuclease specific for ACA sites. During adverse conditions, the activated MazF generates a stress induced translation machinery, composed of MazF-processed mRNAs and selective ribosomes that specifically translate these processed mRNAs.
Apoptosis is a physiological response in development and homeostasis of metazoans. Apoptosis is triggered during pathological events as a means to renew affected tissues and eliminate cancer cells. The immune system regulates the extrinsic pathway of apoptosis, where signals such as TNFα or displayed ligands on the surface of immune cells trigger signal cascades by death receptors present on targeted cells.
Prevalence of Symptom Clusters in Cancer Patients at First Presentation in Palliative Care Clinic as per Different Disease Groups
Cancer has its own disease burden and patients usually suffer from symptom clusters when they are referred for palliative treatment. Identification of symptom cluster trajectories will help clinician to take into account measures that can optimize quality of life of palliative patients. Therefore the aim of this paper is to determine the overall prevalence of symptoms and symptoms clusters in different disease groups according to etiology at the time of first visit to Palliative care clinic by using HIS Palliative First Assessment note indicating Edmonton symptom scale.
Although NK cells are recognized as effector lymphocytes of the innate immune system, they also regulate the adaptive immune response by releasing inflammatory cytokines and developing immunological memory. Unlike other lymphocytes such as T or B cells, NK cells do not express rearrangeable, antigen-specific receptors.
The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.
VA-Radiation Oncology Quality Surveillance Program: Enhancing Quality Measure Data Capture, Measuring Quality Benchmarks and Ensuring Long Term Sustainability of Quality Improvements in Community Care
High quality cancer care improves patient survival and quality of life. Radiation plays an important role in cancer management, given that over 50% of all cancer patients receive radiation therapy as either a primary treatment or for palliation. Ensuring quality of radiotherapy specifically, is therefore important to achieving optimal patient outcomes.
Liver fibrosis is a reversible wound-healing response in which a variety of cells and factors are involved in and results in excessive deposition of extracellular matrix (ECM). Cirrhosis is one of the significant causes of portal hypertension and end-stage liver disease, and it is the 14th most common cause of death around the world. Approximately 1.03 million people worldwide die from liver cirrhosis every year.
Reduced BCR Signaling and a Metabolic Shift Accompanies Malignant Progression of Follicular Lymphoma: A Lesson from Transcriptomics
Lymphoma represents the most common form of hematological malignancy in the developed world, accounting for 3.6% of all cancers and 55.6% of all blood cancers in Europe, with non-Hodgkin lymphomas (NHL) representing 90% of cases.
MicroRNAs (miRNAs) are short double-stranded regulatory molecules derived from precursor transcripts called primary miRNAs (pri-miRNAs) and transcribing in the nucleus from chromosomal DNA by the RNA polymerase II. These pri-miRNAs were shown to contain internal imperfect hairpin structures which are processed by DCL (dicer-like) enzyme
In recent years, various discussions, disagreements and opinions are seen in the field of athletics. For example, in long distance such as marathon, the recommended way of running has changed. In other words, it has been said that landing with the heel is good before, but recently there is some information that the first-class runner is landing on the toe
HPV 16/18 E6 oncoprotein has been evaluated as a useful biomarker with prognostic abilities as it can detect pre-cancer and cancerous states of cervical cancer progression. A positive E6 assay indicates a high correlation to the cervical cancerous phenotype, not the potential for cervical cancer, thus high specificity in triaging patients during screening. E6 levels of expression associate directly with the severity of cervical intraepithelial neoplasia (CIN) lesions and the risk of
Family Planning Laboratory Review of Factors Affecting the Choice of Contraceptive Methods in Three Teenagers Populations' in Thrace, Greece
Contraception encompasses the concept of avoiding a pregnancy, and is aimed at women of reproductive age who, although are sexually active, do not want to achieve any pregnancy at their option fertility preservation and family planning
Antisense Inhibition of accA in E. coli Suppressed luxS Expression and Increased Antibiotic Susceptibility
Multidrug resistant (MDR) bacteria, which are resistant to more than one antibiotic, present an enormous challenge for medical communities and organizations worldwide. For example, Acinetobacter baumannii is a highly contagious MDR gram-negative bacterium (GNB) that inhabits hospitals and causes 64% of urinary tract infections associated with the use of catheters. Alexopoulou et al. found that there were more healthcare-associated infections caused by GNB than Gram-positive Cocci (GPC) bacte
Psychosocial Aspects of Drug Prescription: Recognizing These Phenomena to Improve the Quality of Clinical Practice
The medical prescription corresponds to a complex act, which requires knowledge, professional experience, specific skills, a great sense of responsibility and an ethical attitude.
Commentary on “Integrative Transcriptomics, Proteomics, and Metabolomics Data Analysis Exploring the Injury Mechanism of Ricin on Human Lung Epithelial Cells”
Ricin toxin (RT) is classified as a potential bio-threat agent in assassinations and terrorism due to its extreme toxicity. Due to aerosol RT exposure is the most lethal route, it is urgent to study its injury mechanism.
The ventricular septal defect (VSD) is the most frequent congenital heart disease in humans. It is defined as an opening in the septum separating the left and the right ventricle. This gap results in a mixture of oxygenated and deoxygenated blood and in an enhanced blood flow towards the lung and the left ventricle, a condition that leads to severe diseases such as left ventricular hypertrophy as well as pulmonary edema and dilatation.
The last years have witnessed an increased interest in the genetic, epigenetic and transcriptional heterogeneity of mammalian hearts under basal and disease conditions. Although it is known for a long time that the heart consists of several, functionally different cell populations, more detailed insights into the potential heterogeneity of individual cell populations, such as cardiomyocytes, endothelial cells or fibroblasts were hindered by the lack of appropriate techniques.
Commentary on: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound Beta 1- Adrenergic Receptor
G protein coupled receptors (GPCRs) comprise a large superfamily of transmembrane proteins containing more than 800 unique family members. Critically, GPCRs mediate most of the cell responses to extracellular stimuli including hormones, neurotransmitters, light, taste, etc.
By deduction from complexity of (behavioral) models, we develop an entropic computational tool to distinguish erroneous/redundant eye movements from task relevant eye movements.
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