Volume 3, Issue 2, p35-70
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Prognosis of Patients with Advanced Liver Disease and Positive Stress Echocardiograms: Impact of Coronary Artery Disease, Non-alcoholic Steatohepatitis, and Beta-blocker Therapy
Cardiac Complications are the leading cause of mortality after orthotopic liver transplantation. Advanced liver disease patients with positive DSE are at increased risk. CAD, beta blocker use and NASH are independently associated with cardiac events.J Clin Cardiol, 2022, Volume 3, Issue 2, p35-42 | DOI: 10.33696/cardiology.2.032
Estimated Plasma Volume Status (ePVS) for Diastolic Heart Failure in the Intensive Care Unit: A Retrospective Cohort Study
Diastolic heart failure (DHF) is also be regarded as heart failure with preserved ejection fraction (HFpEF), is estimated to occur in 40 to 50% of patients with HF. More than 70% of HF patients over the age of 65 had HFpEF, and the incidence and prevalence of HFpEF has been increased by 10% every 10 years in comparison to HF with reduced ejection fraction (HFrEF), and this gap is expected to widen in the coming years.J Clin Cardiol, 2022, Volume 3, Issue 2, p43-46 | DOI: 10.33696/cardiology.2.033
Beta 3-Adrenergic Receptor (β3-AR) Activation at the End of Sustained Ischemia and/or Early Reperfusion may Prove to be a Valuable Cardioprotective Strategy
The contribution of β3-AR activation towards ischemiareperfusion (IR) damage largely depends on the disease stage, severity, experimental model as well as drug specificities which should be considered when investigating β3-AR pharmacology for potential therapeutic applications. These conceptions largely contribute to the discrepancies of the subsequent role of β3-AR activation in the cardiovascular disease process.J Clin Cardiol, 2022, Volume 3, Issue 2, p47-50 | DOI: 10.33696/cardiology.2.034
Cardiac Amyloidosis: A Survey of Current Awareness, Diagnostic Modalities, Treatment Practices, and Clinical Challenges Among Cardiologists in Selected Middle Eastern Countries
Cardiac amyloidosis (CA) is a progressive disease affecting the normal cardiac structure and function. CA could be isolated or associated with a spectrum of organ involvement, including the kidneys, lungs, nervous systems, bones, and others.J Clin Cardiol, 2022, Volume 3, Issue 2, p51-59 | DOI: 10.33696/cardiology.2.035
Effects of Anastomotic Angles and Distances of the Bypass Graft to the Stenosis on Blood Flow Hydrodynamics in a Bypass Grafting Coronary Artery
It is believed that the proper distance between the grafting location and the stenosis location and the appropriate angle of graft or transplantation in the blocked artery of the heart are two important factors in the removal or decrease of reappearance and re-development of intimal hyperplasia (IH), blood clotting, and re-blockage of the surgical artery. In the present study, a 3-D geometry of the host coronary artery as non-elastic with 75% symmetric axial cross-sectional area reduction is considered.J Clin Cardiol, 2022, Volume 3, Issue 2, p60-70 | DOI: 10.33696/cardiology.2.036
Chest Pain in Repeated Emergency Department Visitors
Chest pain is the leading symptom in 5 to 8% of all emergency department (ED) visits and is also one of the major reasons of repeated ED visits, causing around 6% of these cases . Generally, in 15 to 25% of patients with chest pain, acute myocardial infarction (AMI) is the underlying cause.
Lipoprotein Apheresis: First FDA Indicated Treatment for Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).
Paradoxical Low Flow Aortic Stenosis: A Clinical Dilemma
Internists as well as cardiologists often receive echocardiogram reports which failed to offer a clear definition of the aortic stenosis (AS) severity due to discordant data regarding the aortic valve gradients and the valve area. Sometimes AS appears severe according to the valve area criteria, in spite of the fact that gradients across the valve are not in the severe range.
Acute Success and Long-term Follow-up of Catheter Ablation of Isthmus-dependent Atrial Flutter; A Comparison of 10 mm Tip Standard, 6 mm Tip Irrigated Radiofrequency, and Cryotherapy Catheters
Various catheter ablation technologies have evolved to improve the procedural success and safety of cavotricuspid isthmus (CTI) block. Numerous studies have compared the different energy types, catheter tip sizes, and energy settings.
A View on the Contribution of Hedgehog Signalling to Ventricular Septal Development
The ventricular septal defect (VSD) is the most frequent congenital heart disease in humans. It is defined as an opening in the septum separating the left and the right ventricle. This gap results in a mixture of oxygenated and deoxygenated blood and in an enhanced blood flow towards the lung and the left ventricle, a condition that leads to severe diseases such as left ventricular hypertrophy as well as pulmonary edema and dilatation.
Hypertrophic Cardiomyopathy and the Troponins: The Enigma Remains
Hypertrophic cardiomyopathy (HCM) is a heart muscle disorder and is the most common form of Mendelianinherited heart disease, affecting approximately 0.2% of the global population. In adults the disease is often inherited as an autosomal dominant trait caused by mutations, mainly in one of the 23 cardiac sarcomere protein genes.
Body Mass Index and Treatment Response in Patients with Cardiac Light-Chain Amyloidosis
Elevated body mass index (BMI) has been associated with an increased risk of cancer and has been shown to have a negative impact on survival in patients with breast, prostate, oral cancer, and leukemia. In plasma cell dyscrasias, obesity has not only been shown to be a risk factor for the development of multiple myeloma, but also has been associated with a higher rate of progression from monoclonal gammopathy of unknown significance (MGUS) to multiple myeloma, and if intervened on, has bee
Mono- and Multi-nucleated Cardiomyocytes Do Not Constitute Transcriptionally Distinct Entities
The last years have witnessed an increased interest in the genetic, epigenetic and transcriptional heterogeneity of mammalian hearts under basal and disease conditions. Although it is known for a long time that the heart consists of several, functionally different cell populations, more detailed insights into the potential heterogeneity of individual cell populations, such as cardiomyocytes, endothelial cells or fibroblasts were hindered by the lack of appropriate techniques.
Commentary on: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound Beta 1- Adrenergic Receptor
G protein coupled receptors (GPCRs) comprise a large superfamily of transmembrane proteins containing more than 800 unique family members. Critically, GPCRs mediate most of the cell responses to extracellular stimuli including hormones, neurotransmitters, light, taste, etc.
Predicting COVID-19 Hospitalized Patients’ Outcome with Homocysteine
The COVID-19 pandemic has provoked a global, rapid increase of cases due to the high infectivity of the etiological agent, COVID-19 virus. In February 2021, over 110 million confirmed COVID-19 cases with 1 million deaths were reported worldwide (www.who.int).
Beneficial Effects of Surgical Closure of Atrial Septal Defect Outweigh Potential Complications in Sick Infants
Atrial septal defect (ASD) is a common congenital heart disease diagnosed during childhood. Persistently increased pulmonary blood flow and dilated right atrium (RA) and right ventricle (RV) result in multiple symptoms and morbidities in adulthood; untreated adults may develop exercise intolerance, congestive heart failure, atrial tachyarrhythmias, pulmonary hypertension (PH), embolic stroke, or even death.
Cardiac Stem Cell Therapy, Quo Vadis
Cardiovascular disease causes 30% of global mortality and is still the number one cause of death worldwide. A main patho-physiological process is the coronary disease leading to malperfusion and ischemic cardiac disease as well as cardiac infarction.
Percutaneous Treatment of Mitral Valve Regurgitation: An Evolving Field
In the past two decades great interest has developed for less-invasive, percutaneous mitral valve (MV) repair strategies. This is mainly due to the increasing number of elderly patients with comorbidities and/or patients with left ventricular (LV) dysfunction, that are associated with a high surgical risk.
Blood Pressure Lowering May Decrease Cognitive Decline; But Are We Ready to Lower Blood Pressure in the Real World?
Dementia and hypertension are highly prevalent, epidemiologically related chronic conditions disproportionately affecting older persons; approximately 97% of persons with dementia and 66% with hypertension are over the age of 65.
The Value of the Left Atrial Appendage Orifice Perimeter of 3D Model Based on 3D TEE Data in the Choice of Device Size of LAmbre™ Occluder
Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it cannot fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography (CT) imaging dataset of the 41 patients who underwent LAA occlusion with LAmbre™ system.
Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19
After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19.
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?
Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life.
Asystole during Tilt Testing-Induced Syncope: A Long-Term Follow-Up
The vasovagal (VV) syncope, a variant of neurally mediated reflex syncopal syndromes is a common clinical entity and is one of a heterogeneous group of disorders of orthostatic intolerance that can be identified during an upright tilt table (TT) test. The clinical response to this test is varied, with a majority of the patients exhibiting a mixed response (vasodepressor-cardioinhibitory) and the remainder either a vasodepressor or cardioinhibitory predominant response depending on the relative d
Thyroid Hormones in Dilated Cardiomyopathy: Is It a Promising Therapeutic Option?
Dilated cardiomyopathy (DCM) is chronic heart muscle disease characterized by progressive ventricular enlargement and contractile dysfunction involving either left or both ventricles. It is considered one of the leading causes of heart failure with reduced ejection fraction (HFrEF) worldwide
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease
Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromo- and extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt.