Archives of Pharmacology and Therapeutics

Review Article Open Access

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Tamer A. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang

Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers.

Review Article Open Access

Pharmacologic Therapies for Non-Muscle Invasive Bladder Cancer: Current and Future Treatments

Ilana P. Goldberg, Benjamin Lichtbroun, Eric A. Singer, Saum Ghodoussipour

Bladder cancer is the sixth most common malignancy in the United States and 70% of cases are non-muscle invasive at the time of diagnosis. Effective treatment is crucial to prevent progression, which occurs in about 30% of patients. The American Urological Association (AUA) guidelines recommend treatment of non-muscle invasive bladder cancer (NMIBC) with intravesical Bacille Calmette-Guerin (BCG) and chemotherapy.

Research Article Open Access

ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation

Kameswari S. Konduri, Ram Pattisapu, Jogi Pattisapu, Girija G. Konduri, John Zwetchkenbaum, Bidhan Roy, Monalisa Barman, Adria Frazier, Brett L. Hurst, Nejat Duzgunes

Inhaled budesonide benefits patients with COVID-19. ProLung™-budesonide enables the sustained, low dose administration of budesonide within a delivery vehicle similar to lung surfactant.

Commentary Open Access

Is There a Simple and Easy Way to Detect Singlet Oxygen? Comparison of Methods for Detecting Singlet Oxygen and Application to Measure Scavenging Activity of Various Compounds

Tokuko Takajo, Kazunori Anzai

Reactive oxygen species (ROS) are known to exert both beneficial and harmful effects in the human body. Singlet oxygen (1O2), is highly reactive and considered as one of the ROS, although it is not a radical molecule.

Commentary Open Access

Artificial Intelligence in Pharma: Positive Trends but More Investment Needed to Drive a Transformation

Peter Henstock

Over the past few years, pharmaceutical R&D has become aware of the potential benefits of leveraging artificial intelligence and its collective subfields including machine learning, deep learning, data science and advanced analytics.

Commentary Open Access

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

Sharuk L. Khan, Falak A. Siddiqui

This article is an extension to our recently published article in Asian Journal of Pharmaceutical and Clinical Research, entitled “Β-Sitosterol: Isolation from Muntingia Calabura Linn. Bark Extract, Structural Elucidation, and Molecular Docking Studies as Potential Inhibitor of SARSCoV-2 Mpro (COVID-19)”[1].

Brief Report Open Access

Pharmacogenetic Variants in the DPYD and TYMS Genes are Clinically Significant Predictors of Fluoropyrimidine Toxicity: Are We Ready for Use in our Clinical Practice

Muhammad Wasif Saif, Hilal Hachem, Sneha Purvey, Ruchi Hamal, Lulu Zhang, Nauman Saleem Siddiqui, Amandeep Godara, Robert B. Diasio

Fluoropyrimidines have been extensively used for almost 6 decades to treat a variety of solid cancers, especially colon, gastric, anal, rectal, head & neck and breast. However, 31–34% of patients encountered grade 3–4 adverse events (AEs) with 0.5% mortality oftennecessitating dose reduction or discontinuation. 

Review Article Open Access

How Traditional Healers Diagnose and Treat Diabetes Mellitus in the Pretoria Mamelodi Area and How Do These Purported Medications Comply with Complementary and Alternative Medicine Regulations

Ondo Z.G

CAM is widely used by patients to treat and prevent certain diseases, providing emotional and physical support [1]. The National Centre for Complementary and Alternative Medicine (NCCAM) defines CAM as a “group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine” [2].

Research Article Open Access

Psychosocial Aspects of Drug Prescription: Recognizing These Phenomena to Improve the Quality of Clinical Practice

Jose Luis Turabian

The medical prescription corresponds to a complex act, which requires knowledge, professional experience, specific skills, a great sense of responsibility and an ethical attitude. 

Editorial Open Access

Platelet Hyperactivity and Dysfunction in Diabetes and Cancer

Bahram Alamdary Badlou

However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.

Research Article Open Access

Molecular Detection of Plasmid - Mediated Quinolone Resistant Genes in Uropathogenic E. coli from Tertiary Referral Hospital in Tehran , Iran

Ali Badamchi, Shima Javadinia, Reza Farahani, Hamid Solgi, Azardokht Tabatabaei

Urinary Tract Infection (UTI) due to Escherichia coli is the most common bacterial infection. Fluoroquinolones are commonly used for the treatment of UTI because isolated microorganisms are frequently resistant to aminopenicillins and trimethoprim- sulfamethoxazole and fluoroquinolones are given orally [1].

Review Article Open Access

Domination of Nephrotic Problems among Diabetic Patients of Bangladesh

Mohiuddin AK

Nearly 80% of people with diabetes live in low and middle-income countries. It increases healthcare use and expenditure and imposes a huge economic burden on the healthcare systems

Editorial Open Access

Diverse Therapeutic Applications of Onion

Preetismita Borah, Bimal Krishna Banik

Onion has been a very useful vegetable for human. The organic molecules present in onion are extremely diverse and exert numerous pharmacological pathways to prevent diseases

Review Article Open Access

Why Do Patients Not Meet the Pharmacological Treatment?

Jose Luis Turabian

Therapeutic compliance has been defined as the degree to which the behaviour of a person corresponds with the recommendations of the health professional [1].