Volume 5, Issue 1, p1-81
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Unapproved use of an approved drug is called “off-label” use. In line with European Medicine Agency’s pharmacovigilance directive, off-label use “relates to situations where a medicinal product is intentionally used for a medical purpose not in accordance with the authorised product information (SmPC).Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p1-4 | DOI: 10.33696/Pharmacol.4.036
The SARS-CoV-2 virus, responsible for covid-19, had an animal origin and jumped to humans in 2019. In 2020 alone, COVID-19 infected almost 100 million people around the planet and ended with the lives of 2 million people. The development in a very short space of time, of vaccines against COVID-19, in response to the urgency of the pandemic, is a transcendental milestone in the history of medicine.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p5-7 | DOI: 10.33696/Pharmacol.4.037
POSTCOVID-19WAR Era, Interaction between Cancer-Hematologic Disorders- Diabetes Significantly Increased by COVID-19 Variants, Aggressively
Understanding the mechanism of bidirectional interaction between different angles of the death triangle is a lifesaving novel idea that I invented in 2018. Platelet hyperactivity and dysfunction in diabetes and cancer patients were already known facts  but whether different COVID-19 variants could activate and/or accelerate death triangle machinery?Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p8-10 | DOI: 10.33696/Pharmacol.4.038
Keeping Ready against Omicron and Future Variants: Can Ivermectin Prophylactic Effects Improve the Vaccination Effects against COVID-19?
The standard treatment options for Coronavirus disease 2019 (COVID-19) remain challenging despite community vaccinations and reduced mortality. As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to evolve and new strains emerge, diversity in the use of existing antiviral drugs has become a crucial therapeutic tool in combating the COVID-19 epidemic.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p11-17 | DOI: 10.33696/Pharmacol.4.039
Proto-oncogenes like C-MYC, EGFR and others have physiological function in regeneration, wound and any stressfully injury to maintain tissue echotexture and healing. Notably, these growth factors work together and had life span to retain to basal level after tissue remodeling and retain its function like what happen in partial hepatectomy.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p18-21 | DOI: 10.33696/Pharmacol.4.040
Reflections on COVID-19 Pharmacological Treatment and Beyond: Beware of “Salads” with Many Ingredients but Low Scientific Content
The pandemic triggered by SARS-CoV-2 has changed since that first case in Wuhan in 2019. We currently have efficient vaccines that have allowed us to return to our daily activities. But, SARS-CoV-2 remains a public health emergency of international concern.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p22-24 | DOI: 10.33696/Pharmacol.4.041
Application of Halides Complexes of Ruthenium (II) in Metallopharmaceuticals and in Material Science: Part-I
Ruthenium readily forms coordinate-complexes and these complexes have their applications in diverse fields. A survey of literature shows that designing of new ligands that can be complexed with Ruthenium (Ru) in various oxidation states can lead to development of new materials with diverse applications.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p25-35 | DOI: 10.33696/Pharmacol.4.042
From Data to Knowledge: A Mini-Review on Molecular Network Modeling and Analysis for Therapeutic Target Discovery
Successful drug development is a risky and lengthy process that can take over ten years and consume billions of dollars. Target discovery is a critical stage of drug development for the identification of key molecules and pathways that can be targeted by novel therapeutics to find more effective treatments. Due to the rapid development in artificial intelligence and machine learning techniques over the past decadeArch Pharmacol Ther, 2023, Volume 5, Issue 1, p36-43 | DOI: 10.33696/Pharmacol.4.043
Dose-dependent Oxidative Damage of Molnupiravir (Antiviral Drug for Treatment of COVID-19) in Lung, Liver, Heart, and Kidney Tissues in Rats
Molnupiravir (MOL) is an orally absorbed prodrug of the ribonucleoside analogue N-hydroxycytidine, which has in vitro activity against several coronaviruses, including SARS-CoV-1 and 2. It remains to be seen whether long term MOL has serious side effects. The side effects of MOL, which was the first to be allowed for oral use during the pandemic process, are not yet fully known. In this study, it was aimed to investigate the the mechanisms of possible dose-dependent damage on liver, lung, heart, and kidney tissues.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p44-52 | DOI: 10.33696/Pharmacol.4.044
Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies
Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p53-66 | DOI: 10.33696/Pharmacol.4.045
Berberine, a naturally occurring alkaloid, is widely explored for several health benefits, including weight management and metabolic disorders. The major pharmacological action of berberine is reported to be by activation of AMP-activated protein kinase, while its other clinical outcomes are devoid of clear mechanism of action/s. Hence in this study a detailed pharmacology of berberine and its two major metabolites (berberrubine, and jatrorrhizine) in humans was evaluated using well established Insilco tools.Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p67-81 | DOI: 10.33696/Pharmacol.4.046
Therapeutic compliance has been defined as the degree to which the behaviour of a person corresponds with the recommendations of the health professional .
Onion has been a very useful vegetable for human. The organic molecules present in onion are extremely diverse and exert numerous pharmacological pathways to prevent diseases
Appropriate medicinal drugs can save life of any patientat risk with high mortality and morbidity. All ongoingcosts and benefits are covered mainly by the health insurance, the pharmaceutical, and alternative medicine industry.
Nearly 80% of people with diabetes live in low and middle-income countries. It increases healthcare use and expenditure and imposes a huge economic burden on the healthcare systems
Molecular Detection of Plasmid - Mediated Quinolone Resistant Genes in Uropathogenic E. coli from Tertiary Referral Hospital in Tehran , Iran
Urinary Tract Infection (UTI) due to Escherichia coli is the most common bacterial infection. Fluoroquinolones are commonly used for the treatment of UTI because isolated microorganisms are frequently resistant to aminopenicillins and trimethoprim- sulfamethoxazole and fluoroquinolones are given orally .
However, the entire coagulation cascade is dysfunctional, in progressed chronic diabetes and cancer patients.
Psychosocial Aspects of Drug Prescription: Recognizing These Phenomena to Improve the Quality of Clinical Practice
The medical prescription corresponds to a complex act, which requires knowledge, professional experience, specific skills, a great sense of responsibility and an ethical attitude.
How Traditional Healers Diagnose and Treat Diabetes Mellitus in the Pretoria Mamelodi Area and How Do These Purported Medications Comply with Complementary and Alternative Medicine Regulations
CAM is widely used by patients to treat and prevent certain diseases, providing emotional and physical support . The National Centre for Complementary and Alternative Medicine (NCCAM) defines CAM as a “group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine” .
Continuous spikes during slow wave sleep (CSWS) syndrome is an age-related and self-limited severe epileptic encephalopathy characterized by electrical status epilepticus in sleep (ESES) on electroencephalogram, seizures, and developmental regression
Accidental admitting and using (un-) known drugs might manipulate health and/or disease(s) of a subject in a positive (healing) and/or negative way (increased mortality and morbidity rate).
Dexamethasone: The First Drug to be Shown to Decrease Mortality in Critically Ill Patients with COVID-19
The precise role of corticosteroids for treatment of coronavirus disease 2019 (COVID-19) is unclear due to lack of randomized trials.
Pharmacogenetic Variants in the DPYD and TYMS Genes are Clinically Significant Predictors of Fluoropyrimidine Toxicity: Are We Ready for Use in our Clinical Practice
Fluoropyrimidines have been extensively used for almost 6 decades to treat a variety of solid cancers, especially colon, gastric, anal, rectal, head & neck and breast. However, 31–34% of patients encountered grade 3–4 adverse events (AEs) with 0.5% mortality oftennecessitating dose reduction or discontinuation.
COVID-19 is the new emerging viral infection that already cause global public health problem [1-3]. More than 220 countries/territories are already attacked and there are more than 17 million patients around the world
This article is an extension to our recently published article in Asian Journal of Pharmaceutical and Clinical Research, entitled “Β-Sitosterol: Isolation from Muntingia Calabura Linn. Bark Extract, Structural Elucidation, and Molecular Docking Studies as Potential Inhibitor of SARSCoV-2 Mpro (COVID-19)”.
Choosing an individual medication for a particular patient is one of the most important clinical decisions in family medicine (FM). Prescription of drugs is currently the main tool of FM and that’s the main source of prescription of drugs.
Miscanthus capensis is a hardy, evergreen, medium-high, clump-forming grass that belongs to the Poaceae family. It is used in South Africa for the treatment of pimples, wounds, eczema, and acne.
Artificial Intelligence in Pharma: Positive Trends but More Investment Needed to Drive a Transformation
Over the past few years, pharmaceutical R&D has become aware of the potential benefits of leveraging artificial intelligence and its collective subfields including machine learning, deep learning, data science and advanced analytics.
Is There a Simple and Easy Way to Detect Singlet Oxygen? Comparison of Methods for Detecting Singlet Oxygen and Application to Measure Scavenging Activity of Various Compounds
Reactive oxygen species (ROS) are known to exert both beneficial and harmful effects in the human body. Singlet oxygen (1O2), is highly reactive and considered as one of the ROS, although it is not a radical molecule.
At the beginning of Covid-19 pandemic, we proposed to use hydroxychloroquine (HCQ) and intranasal interferon (IFN) a-2b spray to prevent SARS-CoV-2.
Since the declaration of COVID-19 as a pandemic in March 2020 , there have been more than 100 million reported cases of COVID-19 worldwide and more than 2.1 million deaths .