Volume 6, Issue 1, p1-33

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Why Can Modulation of α6-Containing GABAA Receptors Reduce the Symptoms of Multiple Neuropsychiatric Disorders?

α6-containing GABAA receptors (α6GABAARs) are strongly expressed in cerebellar granule cells, where they mediate a correctly timed and precise coordination of all muscle groups that execute behavior and protect the brain from information overflow. Recently, it was demonstrated that positive modulators with a high selectivity for α6GABAARs (α6-modulators) can reduce the symptoms of multiple neuropsychiatric disorders in respective animal models to an extent comparable with established clinical therapeutics.

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p1-7 | DOI: 10.33696/Pharmacol.6.047

Aldosterone Synthase Inhibitors for Treatment of Hypertension and Chronic Kidney Disease

Aldosterone excess is known to worsen hypertension and kidney function. Three selective aldosterone synthase inhibitors (ASIs) were evaluated in 3 phase 2 trials. In the first study, the ASI baxdrostat 2 mg orally once daily decreased systolic blood pressure (SBP) by 11.0 mmHg compared with placebo after 12 weeks in patients with treatment-resistant hypertension. In the second study including patients with uncontrolled hypertension, placebo-corrected reduction in SBP with lorundrostat 50 mg once daily was 9.6 mmHg after 8 weeks.

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p8-12 | DOI: 10.33696/Pharmacol.6.048

Comprehensive Network and Structural Analysis of Bovine Papillomavirus, Squamous Cell Carcinoma Markers, and Elucidation of Efficacy Mechanisms of Phytochemicals from Thuja Occidentalis

Papillomaviruses infect cutaneous tissue in various species including bovines and from benign warts to malignant squamous cell carcinoma causing severe economic losses to the farmers. The mechanisms by which bovine papillomaviruses interact with host tissue are unclear. Hence in this study using classical network analysis tools, we evaluated interactions of Bovine papilloma (BPV) variants, with markers and receptors implicated in squamous cell carcinoma.

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p13-20 | DOI: 10.33696/Pharmacol.6.049

The Domino Effect of Polypharmacy. A Dangerous Catalyst That Starts Numerous Bio-Psycho-Social Chain Reactions

Increasing medicalization causes some disconcerting trends in medical decision making. Polypharmacy is one of its most important consequences. The tendency to equate the concepts of risk factor and disease, the changes in the biomedical assessment of the severity of many health problems, and the increase in the number of pharmacological treatments create a growing set of multimorbidity and polypharmacy, and this produces a dramatic domino effect

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p21-23 | DOI: 10.33696/Pharmacol.6.050

POSTCOVID-19 WAR Era, Abnormally Some Patients being Affected by Exceptional Disease Progression, and Accelerated Excessive Mortality Rate

From 2019, POSTCOVID-19 pandemic attacks, human beings were under pandemic-attacked condition that caused by different industrial modern diseases, and being confronted with unusual disease progression, which increased abnormal excess mortality and morbidity rates. The exact mechanism of action is not completely elucidated yet. What is (un)known?

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p24-26 | DOI: 10.33696/Pharmacol.6.051

Schisandra chinensis in Liver Disease: Exploring the Mechanisms and Therapeutic Promise of an Ancient Chinese Botanical

Background: Schisandra chinensis is a traditional Chinese herbal medicine that has been used for centuries for liver health. The active lignans in Schisandra, including schisandrin and gomisins, have exhibited anti-inflammatory, antioxidant, and hepatoprotective properties in preliminary studies. With rising rates of chronic liver diseases globally, there is interest in the potential therapeutic role of Schisandra

Arch Pharmacol Ther, 2024, Volume 6, Issue 1, p27-33 | DOI: 10.33696/Pharmacol.6.052

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