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Archives of Pharmacology and Therapeutics
ISSN: 2688-9609
2023
Volume 5, Issue 1, p1-35
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Off Label Use as an Indicator of Therapeutic Need in Pediatrics
Silvia Miriam Cammarata
Unapproved use of an approved drug is called “off-label” use. In line with European Medicine Agency’s pharmacovigilance directive, off-label use “relates to situations where a medicinal product is intentionally used for a medical purpose not in accordance with the authorised product information (SmPC).
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p1-4 | DOI: 10.33696/Pharmacol.4.036
The Role of the General Practitioner in Vaccination against COVID-19
Jose Luis Turabian
The SARS-CoV-2 virus, responsible for covid-19, had an animal origin and jumped to humans in 2019. In 2020 alone, COVID-19 infected almost 100 million people around the planet and ended with the lives of 2 million people. The development in a very short space of time, of vaccines against COVID-19, in response to the urgency of the pandemic, is a transcendental milestone in the history of medicine.
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p5-7 | DOI: 10.33696/Pharmacol.4.037
POSTCOVID-19WAR Era, Interaction between Cancer-Hematologic Disorders- Diabetes Significantly Increased by COVID-19 Variants, Aggressively
Bahram Alamdary Badlou
Understanding the mechanism of bidirectional interaction between different angles of the death triangle is a lifesaving novel idea that I invented in 2018. Platelet hyperactivity and dysfunction in diabetes and cancer patients were already known facts [1] but whether different COVID-19 variants could activate and/or accelerate death triangle machinery?
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p8-10 | DOI: 10.33696/Pharmacol.4.038
Keeping Ready against Omicron and Future Variants: Can Ivermectin Prophylactic Effects Improve the Vaccination Effects against COVID-19?
Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Fatemeh Aziziyan, Chanour Tavakol
The standard treatment options for Coronavirus disease 2019 (COVID-19) remain challenging despite community vaccinations and reduced mortality. As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to evolve and new strains emerge, diversity in the use of existing antiviral drugs has become a crucial therapeutic tool in combating the COVID-19 epidemic.
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p11-17 | DOI: 10.33696/Pharmacol.4.039
Proto-oncogenes Crosstalk, Feedback and Expression, and Anticancer Drugs Resistance
Mahmoud M. Elalfy, Mona G. Elhadidy, Eman Mohamed El Nashar
Proto-oncogenes like C-MYC, EGFR and others have physiological function in regeneration, wound and any stressfully injury to maintain tissue echotexture and healing. Notably, these growth factors work together and had life span to retain to basal level after tissue remodeling and retain its function like what happen in partial hepatectomy.
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p18-21 | DOI: 10.33696/Pharmacol.4.040
Reflections on COVID-19 Pharmacological Treatment and Beyond: Beware of “Salads” with Many Ingredients but Low Scientific Content
Jose Luis Turabian
The pandemic triggered by SARS-CoV-2 has changed since that first case in Wuhan in 2019. We currently have efficient vaccines that have allowed us to return to our daily activities. But, SARS-CoV-2 remains a public health emergency of international concern.
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p22-24 | DOI: 10.33696/Pharmacol.4.041
Application of Halides Complexes of Ruthenium (II) in Metallopharmaceuticals and in Material Science: Part-I
Vishnu Kumar Sahu, Anil Kumar Soni, Kavindra Kumar Mishra, Rajesh Kumar Singh
Ruthenium readily forms coordinate-complexes and these complexes have their applications in diverse fields. A survey of literature shows that designing of new ligands that can be complexed with Ruthenium (Ru) in various oxidation states can lead to development of new materials with diverse applications.
Arch Pharmacol Ther, 2023, Volume 5, Issue 1, p25-35 | DOI: 10.33696/Pharmacol.4.042
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