Journal of Cellular Signaling

2024

Volume 5, Issue 1, p1-50

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Review Article Open Access

Specific Subcellular Localization of Phosphoinositide-Specific Phospholipase C enzymes in Different Human Osteosarcoma Cell Lines

Matteo Corradini, Marta Checchi, Marta Benincasa, Marzia Ferretti, Francesco Cavani, Carla Palumbo, Vincenza Rita Lo Vasco

The role of signal transduction in cancer progression is well established and actively studied, including in osteosarcoma. The signal transduction pathways involved in the regulation of calcium metabolism are being intensively studied, with particular regard to phosphoinositide-specific phospholipase C (PLC) signaling. This family of enzymes helps to modulate calcium metabolism and is interconnected with additional signaling molecules belonging to different pathways.

J Cell Signal, 2024, Volume 5, Issue 1, p1-9 | DOI: 10.33696/Signaling.5.107

Research Article Open Access

MKP-2 Deficiency Leads to Lipolytic and Inflammatory Response to Fasting in Mice

Sadie Junkins, Gabrielle Westenberger, Jacob Sellers, Isabel Martinez, Nabin Ghimire, Cassandra Secunda, Morgan Welch, Urja Patel, Kisuk Min, Ahmed Lawan

The liver plays a crucial role in maintaining homeostasis for lipid and glucose. Hepatic lipid synthesis is regulated by nutritional signals in response to fasting and refeeding. It is known that overnutrition regulates MAPK-dependent pathways that control lipid metabolism in the liver by activating MAPK phosphatase-2 (MKP-2). Uncertainty still exists regarding the regulatory mechanisms and effects of MKP-2 on hepatic response to fasting.

J Cell Signal, 2024, Volume 5, Issue 1, p10-23 | DOI: 10.33696/Signaling.5.108

Research Article Open Access

Monitoring Transcription of miR-15a and miR-124 in Mesenchymal Stem Cells from Adipose Tissue Origin Differentiated into Pancreatic Beta-cells

Hadi Rajabi

MicroRNAs are small, noncoding pieces of nucleic acid with the potential to control mRNA translation. These sequences participate in the regulation of cell dynamic growth and differentiation. In this study, the expression of miR-15a and miR-124 was monitored in adipose-derived tissue stem cells committed to pancreatic β cells in vitro over 28 days. In the current experiment, adipose-derived mesenchymal stem cells were incubated in an induction medium to accelerate differentiation toward the endocrine pancreatic lineage for 28 days with a three-stage protocol.

J Cell Signal, 2024, Volume 5, Issue 1, p24-29 | DOI: 10.33696/Signaling.5.109

Research Article Open Access

Phorbol-12-Myristate-13-Acetate (PMA) Reactivates Replication from HIV-1 Latency and Induces Jurkat Cell Death

Xue Wang, Jiangqin Zhao, Indira Hewlett

HIV-1 has the capability to establish latency during early infection in CD4+ cells, posing a significant challenge to the efforts aimed at curing HIV-1/AIDS. One extensively explored strategy to address this viral latency is the "shock-and-kill" approach. This involves reactivating viral replication using latency reversal agents (LRAs) to induce the death of infected cells. Regrettably, no LRAs with proven effectiveness have been identified thus far.

J Cell Signal, 2024, Volume 5, Issue 1, p30-40 | DOI: 10.33696/Signaling.5.110

Review Article Open Access

Role of Exosomal MicroRNAs in Modulating the Response of Cancer Cells to Paclitaxel Treatment

Lanqing Zhao, Cheng Lv, Hui Xie, Xiaoxu Ding

MicroRNAs (miRNAs) play important roles in gene regulation and have been implicated in various human diseases, including cancer. MiRNAs can be packaged in exosomes and transferred between cells. These exosomal miRNAs regulate intercellular communication and influence almost all aspects of cancer biology, including proliferation, apoptosis, invasion, metastasis, and angiogenesis.

J Cell Signal, 2024, Volume 5, Issue 1, p41-50 | DOI: 10.33696/Signaling.5.111

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Deubiquitinase as Potential Targets for Cancer Immunotherapy

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Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties

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Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP₅₃-Mutated Cancers

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Physiotherapy Research in a Danish University Hospital: A Retrospective Review, 2010-2018

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Role of the Gut Microbiome in the Modulation of Cancer Immunotherapy Response

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Do Support Vector Machines Play a Role in Stratifying Patient Population Based on Cancer Biomarkers

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Prognostic Role of Human Epididymis Protein ₄ (HE₄) in Ovarian Cancer Treatment: Our Point of View

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First In silico Structural Model of Glucokinase-1 from Phytophthora infestans Reveals a Possible Pyrophosphate Binding Site

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Molecular Detection of Plasmid - Mediated Quinolone Resistant Genes in Uropathogenic E. coli from Tertiary Referral Hospital in Tehran , Iran

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Journal of Cellular Signaling

2024

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