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Archives of Cancer Biology and Therapy

ISSN: 2692-8302

2021

Volume 2, Issue 2, p29-53

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Commentary Open Access

Exosome to Promote Cancer Progression via Its Bioactive Cargoes

Austin McMasters, Kelly M McMasters, Hongying Hao

Exosomes are membranous vesicles ranging in size from 30–100 nm in diameter. They are secreted from multiple cell types into the body fluids through exocytosis, a process commonly used for receptor discharge and intercellular communications.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p29-34 | DOI: 10.33696/cancerbiology.2.021
Commentary Open Access

Genetic Predisposition of Breast Cancer in the United Arab Emirates

Ajda Altino, Ahmed Abdel-Aziz, Mouza Al Ameri

This commentary refers to our published article, as highlighted in this article most common gene causing breast cancer in the population living in the United Arab Emirates is BRCA2 followed by BRCA1. This is the first publication discussing about clinical and pathological features of breast cancer in woman with a positive genetic mutation in the United Arab Emirates.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p35-36 | DOI: 10.33696/cancerbiology.2.022
Case Report Open Access

Primary Small Cell Neuroendocrine Carcinoma of Bladder – A Rare Diagnostic Entity

Prachi, Gaurav Sharma

Primary small cell neuroendocrine carcinoma of the urinary bladder is a rare histological type shows poor differentiation and behaves in a highly aggressive manner. It accounts to 0.3- 0.7% of all bladder tumors [1,2]. Neuroendocrine carcinomas predominantly occur in respiratory and gastrointestinal tract and very rarely in the urinary bladder.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p37-39 | DOI: 10.33696/cancerbiology.2.023
Editorial Open Access

Molecular Biology for BCR-ABL1 Quantification for Chronic Myeloid Leukemia Monitorization and Evaluation

Anelis Maria Marin, Gabriela Silva Soares, Dalila Luciola Zanette, Mateus Nóbrega Aoki

Chronic Myeloid Leukemia (CML) is a clonal disorder originated by a pluripotent hematopoietic stem cell, which presents the translocation t(9;22) (q34;q11) in 90% of the cases.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p40-42 | DOI: 10.33696/cancerbiology.2.024
Mini Review Open Access

The Impact of Dido on the Epithelial-Mesenchymal Transition

Agnes Fütterer, Amaia Talavera-Gutiérrez, Carlos Martínez-A

The human body is constituted by more than 200 committed cell types [1], all of which derive from the zygote, a single totipotent cell that divides and differentiates into all the cells of an organism throughout its development. Out of this diversity, we focus our interest here on the epithelial and the mesenchymal cells.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p43-49 | DOI: 10.33696/cancerbiology.2.025
Commentary Open Access

SorLA Targeting - A Method to Overcome Therapy Resistance in Breast Cancer

Hussein Al-Akhrass, Nicolas Pasquier, Johanna Ivaska

Tyrosine kinase-type cell surface receptor HER2- targeted therapies have dramatically improved breast cancer patients’ outcome compared to conventional chemotherapies. In the clinic, HER2 monoclonal antibody trastuzumab with chemotherapy represent the gold standard treatment of HER2-positive breast cancer.

Arch Cancer Biol Ther, 2021, Volume 2, Issue 2, p50-53 | DOI: 10.33696/cancerbiology.2.026
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Recommended Articles

Acute Abdomen due to Perforation of Small Bowel Malignant Melanoma Metastasis

Primary tumors of the small bowel are a rare condition, accounting for 2 to 3% of gastrointestinal tumors. Malignant melanoma is the most common metastatic tumor found in the gastrointestinal tract [1]. It can be localized in different sites, from the oral cavity to the anus. It can also be present as a primary lesion.

Exosome to Promote Cancer Progression via Its Bioactive Cargoes

Exosomes are membranous vesicles ranging in size from 30–100 nm in diameter. They are secreted from multiple cell types into the body fluids through exocytosis, a process commonly used for receptor discharge and intercellular communications.

Primary Small Cell Neuroendocrine Carcinoma of Bladder – A Rare Diagnostic Entity

Primary small cell neuroendocrine carcinoma of the urinary bladder is a rare histological type shows poor differentiation and behaves in a highly aggressive manner. It accounts to 0.3- 0.7% of all bladder tumors [1,2]. Neuroendocrine carcinomas predominantly occur in respiratory and gastrointestinal tract and very rarely in the urinary bladder.

The Link of Nutrient Fluxes to Hepatic Insulin Resistance at Gene Expression

Insulin resistance has been studied extensively at systemic, organ, tissue and cellular and molecular levels. Overnutrition plays an essential role in the development of chronic metabolic diseases such as obesity and type 2 diabetes. For subjects without genetic defects, the development of insulin resistance and type 2 diabetes is a graduate process. How the transition from an insulinsensitive state to an insulin-resistant state occurs, and what the roles of nutrients are in the process have not been fully understood. Here, we try to summarize the current understanding of insulin-regulate gene expression in the liver, and describe a phenomenon of hepatic insulin resistance at gene expression (HIRAGE), which may be linked to overnutrition.

 

Leucocyte-Tumor Cell Hybridization Can Initiate Cancer Metastasis

According to estimates from the International Agency for Research on Cancer, by the year 2030 there will be 22 million new cancer cases and 13 million deaths per year. The main reason for death from cancer is not the initial tumor but it’s metastasis to distant parts of the body, yet this process has remained poorly understood for quite some time.

The Role of ERO1α in Modulating Cancer Progression and Immune Escape

The failure to eradicate minimal residual disease often located at metastatic sites and/or the bone marrow niche continues to be a clinical barrier for successful treatments in cancer.

MicroRNA Signature Targeting Transient Receptor Potential Channels in the Prognosis and Therapy of Cancer

This short communication would to be the continuation of the Santoni’s paper entitled “Targeting Transient Receptor Potential Channels by MicroRNAs drives tumor development and progression” published in: Calcium Signaling, Advances in Experimental Medicine and Biology

Pharmacologic Therapies for Non-Muscle Invasive Bladder Cancer: Current and Future Treatments

Bladder cancer is the sixth most common malignancy in the United States and 70% of cases are non-muscle invasive at the time of diagnosis. Effective treatment is crucial to prevent progression, which occurs in about 30% of patients. The American Urological Association (AUA) guidelines recommend treatment of non-muscle invasive bladder cancer (NMIBC) with intravesical Bacille Calmette-Guerin (BCG) and chemotherapy.

Primary Small Cell Neuroendocrine Carcinoma of Bladder – A Rare Diagnostic Entity

A 75-year-old male patient presented with gross haematuria and pelvic pain since a month. He is a chronic smoker with 40-pack year index. His family history is insignificant. Ultrasonography showed 2 × 2 cm broad based solid heteroechoic mass along the left lateral wall of urinary bladder.

Control of CD4 Helper and CD8 Cytotoxic T cell Differentiation

Engagement of mature T cell receptor (TCR), a multiprotein complex consisting of an αβ heterodimer associated with invariant CD3 signaling proteins, on CD4+CD8+ double positive (DP) thymocytes by selfpeptide/ self-MHC complex on thymic stromal cells results in negative selection of thymocytes expressing strong affinity TCRs and

Chronic IL-1 Exposed AR+ PCa Cell Lines Show Conserved Loss of IL-1 Sensitivity and Evolve Both Conserved and Unique Differential Gene Expression Profiles

Inflammation drives prostate cancer (PCa) progression. While inflammation is a cancer hallmark, the underlying mechanisms mediating inflammation-induced PCa are still under investigation. Interleukin-1 (IL-1) is an inflammatory cytokine that promotes cancer progression, including PCa metastasis and castration resistance. We previously found that acute IL-1 exposure represses PCa androgen receptor (AR) expression concomitant with the upregulation of pro-survival proteins, causing de novo accumulation of castration-resistant PCa cells.

Right Atrial Metastasis from Melanoma Treated with Immunotherapy

It is long known that melanoma has the ability to metastasize widely. Unusual sites of metastases are seen including intracardiac. The literature reports cases of cardiac metastases however, most reports pre-date the more recent era of immunotherapy and targeted agent use and do not describe systemic treatment responses.

Purinergic P2X7 Receptor as a Potential Targeted Therapy for COVID-19-associated Lung Cancer Progression

Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection is a serious threat to lung cancer patients. Hereby, we hypothesize that Coronavirus disease 2019 (COVID-19) may contribute to lung cancer progression by increasing extracellular adenosine triphosphate (ATP) levels and hyperactivating the purinergic P2X purinoceptor 7 receptor (P2X7R).

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