Volume 2, Issue 2, p53-101
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
The Silencing of Casein Kinase I Attenuated Neuromuscular Impairment in a Preclinical Mouse Model of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a fatal progressive neurodegenerative disease, which results in the destruction of upper and/or lower motor neurons in the brain and spinal cord. It usually affects people between 40 and 60-year-old and the average survival from onset to death is 3–4 years .J Exp Pathol, 2021, Volume 2, Issue 2, p53-62 | DOI: doi.org/10.33696/pathology.2.016
Verruciform xanthoma is an uncommon benign mucocutaneous lesion that has a verruciform (wart-like) appearance. It was first described by Shafer in the year 1971 affecting the oral mucosa. The most common site for verruciform xanthoma is the oral mucosa of the gingiva and alveolar mucosa. Extraoral verruciform xanthoma is extremely uncommon.J Exp Pathol, 2021, Volume 2, Issue 2, p63-66 | DOI: 10.33696/pathology.2.017
Tracheostomy insertion is a common procedure used to support weaning from mechanical ventilation or following head and neck surgery. Resolution of the clinical need for tracheostomy is followed by a process of tracheostomy weaning and subsequent decannulation.J Exp Pathol, 2021, Volume 2, Issue 2, p67-74 | DOI: 10.33696/pathology.2.018
Can Early Home administration of Azithromycin with Zinc Help Prevent Severe COVID-19 Disease Progression and Long-COVID?
The novel SARS-CoV-2 belongs to the Betacoronavirus family and contains a single-stranded positive-sense RNA genome. Similar to the two other coronaviruses, SARSCoV- 1 and MERS-CoV, SARS-CoV-2 is also likely to have originated in bats, which serve as established reservoirs for various pathogenic coronaviruses . Although it is still unconfirmed, the most commonly admitted hypothesis suggests that SARS-CoV-2 is transmitted from bats to humans via an unidentified intermediate host species (zoonotic transmission).J Exp Pathol, 2021, Volume 2, Issue 2, p75-89 | DOI: 10.33696/pathology.2.019
Faecal Microbiota Transplantation as Primary Treatment for Clostridioidoes difficile Infection-evidence for Change
Clostridioides difficile is an anaerobic spore-forming gram positive bacillus that infects the gut microbiota leading to gastrointestinal disease with varied severities ranging from self-limiting diarrhea to life-threatening pseudomembranous colitis,J Exp Pathol, 2021, Volume 2, Issue 2, p90-101 | DOI: 10.33696/pathology.2.020
Although NK cells are recognized as effector lymphocytes of the innate immune system, they also regulate the adaptive immune response by releasing inflammatory cytokines and developing immunological memory. Unlike other lymphocytes such as T or B cells, NK cells do not express rearrangeable, antigen-specific receptors.
While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency.
Ketamine has long been used in the field of anesthesia . Its rapid and long-acting analgesic effects associated with its dissociative properties have also established its use in prehospital and emergency department patients.
The currently ongoing coronavirus pandemic, the SARSCOV- 2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of.
Gender Disparities in Outcomes Following Pulmonary Embolism Treatment in the Intensive Care Unit; A Multi-center Retrospective Cohort Study
Pulmonary embolism (PE) is a blockage of blood flow in the pulmonary artery bed that can result in a life-threatening and potentially reversible right ventricular failure . PE remains one of the leading causes of poor prognosis and death, particularly when a shock or right ventricular failure occurs . According to studies, PE is generally manifested in a nonspecific manner
The hepatitis C virus (HCV) genome was isolated during the late 1980s using molecular cloning techniques. It is recognized as the cause of most cases of percutaneously transmitted non-A, non-B hepatitis. It is estimated, that up to 200 million people worldwide are infected with the hepatitis C virus (HCV), more than 3% of the world population.
Mega-Dose Dietary Riboflavin in Treatment in Keratoconus, Post-Refractive Cornea Ectasia and Migraine. Has Its Time Arrived?
Recently, several studies and investigators have shown the beneficial effects of high dose dietary riboflavin (vitamin B2) in the treatment of keratoconus, post-refractive (LASIK, PRK & Radial Keratotomy) ectasia (with sunlight exposure) and patients treated with our own protocol (NIH Clinical Study – www.clinicaltrials.gov - # NCT 03095235) discovered significant relief for intractable migraine headaches and/or ophthalmic migraine (classic migraine visual symptoms without headache).
With readily available cross-sectional imaging, asymptomatic localized renal masses (LRMs) are often incidentally found. The standard management for LRM has been surgical resection, however, detection of masses that are benign or with low metastatic risk has led to interest in minimally invasive alternatives such as percutaneous thermal ablation (TA) or active surveillance
Lipoprotein(a) [Lp(a)] is a genetically determined lowdensity lipoprotein (LDL) particle that is comprised of apolipoprotein(a) [apo(a)] and apolipoprotein B-100 (apoB) moieties. It is well-established that elevated Lp(a) is an independent risk factor for cardiovascular disease (CVD).
Five months into the COVID-19 pandemic, the U.S. death toll from the virus has now surpassed 100,000 people. Many more cases remain nationwide, while an unknown number of patients currently harbor the virus asymptomatically. While health officials are now optimistic regarding the decline in prevalence and number of deaths due to COVID-19 and the possibility of a vaccine by the fall, we cannot lose sight of the bigger picture: the next pandemic.
Rituximab is a chimeric (20% rodent and 80% human) monoclonal antibody that binds to the CD20 antigen present on the cell surface and leads to depletion of mature B-cells [1,2]. It is the first approved monoclonal antibody to be used in the therapy of indolent B-cell non- Hodgkin’s lymphoma and chronic lymphocytic leukemia
Generating Awareness and a Planned Multidisciplinary Treatment Approach Can Save Both the Sight and Life in Retinoblastoma in Developing Countries
While rare, retinoblastoma is the most common (1:16000 – 18000 live births) intraocular and life threatening tumor of childhood [1,2]. According to the World Health Organization (WHO), 66% of children present with symptoms before 2 years of age and 95% before 5 years of age. About 8000 new cases are detected annually with the highest incidence in Africa and India. In fact, more than 1400 cases each year are from India .
Glucocorticoids (GCs) are defined by their role in maintaining glucose homeostasis and natural GCs are a class of corticosteroids secreted by the adrenal cortex. Cortisol is the most important natural GC in humans. Cellular cortisol levels are regulated by the tissue-specific metabolic enzymes 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD 1 and 2); 11β-HSD 1 converts inactive cortisone to active cortisol, while 11β-HSD 2 has the opposite function.
Spontaneous Resolution of Infected Pancreatic Necrosis after Fistulization into Upper Gastrointestinal Tract
A 67-year-old female with a history of arterial hypertension and previous hysterectomy, was recovered, in July 2019, for moderately-severe acute biliary pancreatitis with evidence of stones in gallbladder and bile duct and pancreatic necrosis on imaging (Magnetic Resonance Cholangiopancreatography. A contrast enhanced CT, a week after the admission, showed necrotic areas in the pancreas and a large peripancreatic fluid collection (60 mm long) with air pockets within (acute necrotic collection, with signs of infection. Since she was haemodynamically stable and there was no evidence of organ failure, according to “step-up approach”, she was managed medically with antibiotics (piperacillin-tazobactam + metronidazole) and fluids.
In the article, “Mental Health Framework: Coronavirus pandemic in post-Katrina New Orleans” , Shervington and Richardson offer recommendations about how to anticipate and address disaster-related, trauma exposures associated with the coronavirus pandemic
In January 2020, the World Health Organization (WHO) classified COVID-19 to be a Public Health Emergency of International Concern and declared it a pandemic on March 11, 2020 . Over one hundred and eighty-five million people have been infected by SARS-CoV-2 and roughly four million have died worldwide so far
Ultrasounds are acoustic vibrations that are not perceived by the human ear as their frequency is greater than 20,000 Hz. They are artificially generated by the action of the electric current, whose polarity is periodically reversed, on a quartz crystal, subjecting it, by the action of the electromagnetic field created, to successive contractions and expansions. This alternation of movements generates vibrations, which, transmitted to cellular and intercellular structures, cause collisions and generate heat.
We are witnessing the evolution of the diagnostic imaging that is rapidly becoming available to Women’s Health physicians (OB/GYN’s), enabling the use of technology to augment our ability to medically palpate on examination of the patient, to identify conditions which we were unable to appreciate a short time ago.
The etiology of fetal growth restriction is rooted in inadequate maternal-placental vascular malperfusion (MVM) of the placenta. Risk factors for MVM are broad and include maternal, fetal, and placental antecedent determinants.
Therapeutic compliance has been defined as the degree to which the behaviour of a person corresponds with the recommendations of the health professional .
Scientific Archives is a global publisher initiated with the mission of ensuring equal opportunity for accessing science to research community all over the world. Spreading research findings with great relevance to all channels without any barrier is our goal. We want to overcome the challenges of Open Access with ensured quality and transparency.