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2022

Volume 3, Issue 1, p1-28

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Adenosquamous Carcinoma of Ascending Colon: Where an Unseen is Seen

Colorectal carcinoma is one of the most malignant solid tumors in Western countries. With the exception of the lower rectum, most primary malignant colorectal tumors are adenocarcinomas.

J Exp Pathol, 2022, Volume 3, Issue 1, p1-5 | DOI: 10.33696/pathology.3.031

Cancer Stem Cells, Together with Mesenchymal Stem Cells and Other Cooperative Cells, Govern the Initiation and Development of Cancer

Until the end of last century, the origin and development of cancers were mostly attributed to the proliferation of their active cells, operative in collaboration with non-cancer cells of the patients. In particular, an important role was attributed to cells now recognized as mesenchymal stem cells (MSCs), first considered a few decades ago. Initially, however, the role attributed to these cells was only limited.

J Exp Pathol, 2022, Volume 3, Issue 1, p6-11 | DOI: 10.33696/pathology.3.032

Can Artificial Intelligence Help?

Papillary thyroid carcinoma (PTC) is the fifth most common malignant tumor in women worldwide and the most common cancer in women younger than 25 years [1]. Fortunately, the first is that the prognosis is excellent compared to other malignant tumors [2].

J Exp Pathol, 2022, Volume 3, Issue 1, p12-15 | DOI: 10.33696/pathology.3.033

Newborns’ Hearing Health Associated with Infectious Diseases in Primary Healthcare Infectious Diseases and Neonatal Hearing Screening

According to the World Health Organization [1], hearing loss is unevenly distributed worldwide and importantly associated with each region’s per capita income. Hearing is one of the most important human senses [2], and a healthy auditory system is a prerequisite to language and auditory skill development [3]. Hence, it is a serious matter for patients when their auditory health is affected.

J Exp Pathol, 2022, Volume 3, Issue 1, p16-22 | DOI: 10.33696/pathology.3.034

The Proliferative Changes of Renal Afferent Arteriolar Walls and Renin-Angiotensin-Aldosterone System Inhibitors

The hyperfiltration theory of Brenner et al. in 1982 [1], is widely recognized and studied closely as a final common pathway of kidney function deterioration from some point to the irreversible end-stage by any first kidney insult. In the paper, the deterioration of kidney function is induced because of the glomerular hemodynamics,

J Exp Pathol, 2022, Volume 3, Issue 1, p23-28 | DOI: 10.33696/pathology.3.035

Recommended Articles

Endoscopic Ultrasound-Guided Liver Biopsy; the Pathologist’s Perspective

In this study, the safety and efficacy of liver biopsies performed by endoscopic ultrasound (EUS-LB) were compared with those performed via the traditional percutaneous route at our Medical Center between January 2018 and August 2019.

Arid5a Inroads to Immunity, Inflammation, and Cancer

The immune system is essential to host defense because it senses attacking pathogens and elicits protective immune responses. Although immune responses can protect against pathogens, uncontrolled immune responses cause tissue damage and other pathological consequences through their inflammatory mediators. 

Application of Encapsulated Probiotics in Health Care

Probiotics are generally defined as nonpathogenic living organisms that have beneficial effects on host health. The term “probiotic” means “for life” that is derived from Greek language. At first, probiotics was defined as substances that are produced with microorganisms and promote the other microorganisms.

A New Player in an Old Story: FBXO16 Prevents Breast Cancer Tumorigenesis through Disrupting Cellular Function of Nuclear β-Catenin

β-Catenin is the central modulator of the canonical Wnt signaling pathway. Upon Wnt on state, β-Catenin is translocated to the nucleus and function as a transcription coactivator for several oncogenes. In Wnt off state, β-catenin is mostly localized in the cytoplasm and sequestered by the destruction complex, the negative regulator of β-catenin expression [2,3].

Pancytopenia: An Update

Peripheral pancytopenia is not a disease by itself; rather it describes simultaneous presence of anemia, leucopenia and thrombocytopenia resulting from a number of disease processes.

The Clinicopathological and Genetic Characteristics of High-grade Gliomas with Histone H3.3 G34 Mutation in Teenagers and Young adults

Chromatin is composed of nucleosomes, with each nucleosome consisting of an octamer of two copies each of histones H3, H4, H2A, and H2B. Chromatin is critical for the control of transcription, replication, DNA repair and other aspects of genomic stability.

Liposarcoma of Laryngeal Vallecula

Liposarcoma (LS) is the most common soft tissue sarcoma (20% of the tumors in adults). This neoplasm was first described by Virchow in 1857 and has been well documented thereafter. Liposarcoma is a common soft tissue malignant tumor and is often found in the lower extremities and retro peritoneum. Only about 5.6% of liposarcomas are found in the head and neck and most of these tumors arise from the soft tissues of the neck [1-3].

Acellular Dermal Matrix in Prosthetic Breast Reconstructive Surgery with Prepectoral Technique: A Literature Review

Breast cancer is the second most commonly diagnosed cancer worldwide, with an incidence of 2.088.850 and a mortality rate of 627,000. Incidence and mortality rate in Europe were 522,513 and 92,000, respectively, while in Italy accounted for 53,000 diagnoses and 12,000 deaths.

Succinate Accumulation Links Mitochondrial MnSOD Depletion to Aberrant Nuclear DNA Methylation and Altered Cell Fate

Epigenetic processes provide a mechanism for integrating metabolic inputs and translating them into various phenotypic outputs [1,2]. Indeed, epigenetic modifiers often require or are inhibited by key citric acid cycle (CAC) metabolites (e.g. succinate,

Mechanistic and Translational Advances Using iPSC-Derived Blood Cells

The human induced pluripotent stem cell (iPSC) technology was developed more than ten years ago and has provided important tools for the mechanistic and cellular interrogation of many diseases [1]. To generate iPSC lines, somatic cells are reprogrammed into cells resembling embryonic stem cells by the overexpression of key transcription factors.

Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice

Candida spp. are often detected from fungal cultures or mycobiome analysis of respiratory secretions, but are not usually treated since, even if detected persistently, the presence is assumed to be benign colonization unless invasive candidiasis in deeply immunocompromised subjects is suspected.

Impact on Microbiology Laboratory Turnaround Times Following Process Improvements and Total Laboratory Automation

Total laboratory automation (TLA) involves the integration of pre- and post-analytical processes through incorporation of multiple, modular systems to perform different tests, on diverse matrices, within the clinical microbiology laboratory, and typically consists of automation for plating, incubation,

Epidemiologic, Clinical, and Biological Characteristics of Adult T-cell Leukemia/Lymphoma in Martinique (1983- 2013)

Adult T-cell leukemia/lymphoma (ATL) was first described in the Southwest islands of Japan in 1977 [1]. Then, the HTLV-1 (human T-lymphotropic virustype 1) was isolated in the United States in 1981 in two patients, one with mycosis fungoïdes and the other with Sezary syndrome [2,3], which have been consequently renamed.

Adenosarcoma of Uterus with Sarcomatous Overgrowth and Rhabdomyoblastic Differentiation - A Rare Pathological Entity

Uterine adenosarcoma is a rare malignancy. It is defined as a biphasic tumor composed of both sarcomatous stroma and benign epithelial components. When the sarcomatous component occupies more than 25 % of the tumor then it is referred to as the sarcomatous overgrowth which accounts to about 10% of uterine adenosarcoma cases [1].

News About the Extracellular Vesicles from Mesenchymal Stem Cells: Functions, Therapy and Protection from COVID-19

The present Commentary is a critical follow-up of a previous review about “Extracellular vesicles, news about their role in immune cells: physiology, pathology and diseases”, appeared in Clinical and Experimental Immunology last June 2019 [1].

The Silencing of Casein Kinase I Attenuated Neuromuscular Impairment in a Preclinical Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a fatal progressive neurodegenerative disease, which results in the destruction of upper and/or lower motor neurons in the brain and spinal cord. It usually affects people between 40 and 60-year-old and the average survival from onset to death is 3–4 years [1].

Verruciform Xanthoma of the Tongue: Case Report and Review of Literature

Verruciform xanthoma is an uncommon benign mucocutaneous lesion that has a verruciform (wart-like) appearance. It was first described by Shafer in the year 1971 affecting the oral mucosa. The most common site for verruciform xanthoma is the oral mucosa of the gingiva and alveolar mucosa. Extraoral verruciform xanthoma is extremely uncommon.

Identification of Laryngotracheal Stenosis During Weaning from Tracheostomy – A Clinical Conundrum

Tracheostomy insertion is a common procedure used to support weaning from mechanical ventilation or following head and neck surgery. Resolution of the clinical need for tracheostomy is followed by a process of tracheostomy weaning and subsequent decannulation.

Can Early Home administration of Azithromycin with Zinc Help Prevent Severe COVID-19 Disease Progression and Long-COVID?

The novel SARS-CoV-2 belongs to the Betacoronavirus family and contains a single-stranded positive-sense RNA genome. Similar to the two other coronaviruses, SARSCoV- 1 and MERS-CoV, SARS-CoV-2 is also likely to have originated in bats, which serve as established reservoirs for various pathogenic coronaviruses [1]. Although it is still unconfirmed, the most commonly admitted hypothesis suggests that SARS-CoV-2 is transmitted from bats to humans via an unidentified intermediate host species (zoonotic transmission).

Faecal Microbiota Transplantation as Primary Treatment for Clostridioidoes difficile Infection-evidence for Change

Clostridioides difficile is an anaerobic spore-forming gram positive bacillus that infects the gut microbiota leading to gastrointestinal disease with varied severities ranging from self-limiting diarrhea to life-threatening pseudomembranous colitis,