Volume 3, Issue 2, p29-64

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Evaluation of the Relationship between Capillaroscopic Symptoms and the Severity of Systemic Lupus Erythematous

Systemic lupus erythematous (SLE) is one of the most common rheumatic diseases with a global incidence of 50 to 70 cases per million people and the prevalence of 500 cases per one million people resulted in significant functional disabilities in 6.2% of cases [1].

J Exp Pathol, 2022, Volume 3, Issue 2, p29-34 | DOI: 10.33696/pathology.3.037

Non-Interventional Treatment of Post-Dural-Puncture Headache; High-Flow Oxygen and Pro-Serotonin Agents a Safe and Effective Alternative

Lumbar punctures are commonly performed for diagnostic and/or therapeutic purposes by threading a needle through the outermost layer of the meninges, the dura mater, and into the intrathecal space within the lumbar region of the spine [1]. The intrathecal space contains cerebrospinal fluid (CSF), a clear and colorless fluid, which surrounds the brain and spinal cord and can provide information regarding intracranial pressures, presence of diseases involving the central nervous system (CNS) or surrounding meninges [2-4]. A common complication of dural puncture is a postdural puncture headache (PDPH) which is defined by The International Headache Society as a “headache that develops within 5 days of dural puncture and resolves within 1 week spontaneously or within 48 hours after effective treatment of the spinal fluid leak”

J Exp Pathol, 2022, Volume 3, Issue 2, p35-39 | DOI: 10.33696/pathology.3.038

Differential Expression of Long Non-coding Ribonucleic Acid (RNA) Genes in Endometriosis-associated Ovarian Cancer (EAOC): A Pilot Meta-analysis for Pathological Insights and Potential Diagnostic Biomarker Identification

Ovarian cancer affects 15 women per 100,000 in Europe [1] but it is not one disease. Epithelial malignancy the most common type of ovarian malignancy and defines the groups termed carcinoma [2,3]. Other malignant subtypes include sarcomas, germ cell tumors and sex-cord stromal tumors [1]. Ovarian carcinomas are subdivided based on histological features, the most common being high-grade serous carcinoma which makes up around 70% of ovarian carcinomas [2,4]. Up to 10% of ovarian carcinomas are endometrioid subtype, having phenotypic and molecular resemblances to endometroid adenocarcinomas that arise in the endometrial cavity [3,5] Clear cell carcinoma (OCCC) and endometrioid carcinoma of the ovary (EnOC) occur on a background of ovarian endometriosis in as many as 70% of cases [6,7]. OCCC is equally as common as endometroid type, perhaps reflecting this shared origin and collectively are often referred to as Endometriosis-Associated Ovarian Carcinomas (EAOCs). Mucinous carcinoma is less common than endometriosisrelated carcinomas at around 3% of ovarian carcinomas [2].

J Exp Pathol, 2022, Volume 3, Issue 2, p40-54 | DOI: 10.33696/pathology.3.039

The Duration of Mechanical Ventilation is the Main Cause of Bacterial/Fungal Superinfection in Critically Ill Patients with COVID-19 at Altitude

The COVID-19 pandemic is associated with a large number of patients spending long periods of time in intensive care units (ICUs), many of them suffering bacterial/fungal superinfections. However, both the incidence and cause of bacterial/fungal superinfections in COVID-19 critically ill patients remain poorly investigated in hospitals located at high altitudes (above 2500 meters).

J Exp Pathol, 2022, Volume 3, Issue 2, p55-64 | DOI: 10.33696/pathology.3.040

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