Archives of Gastroenterology Research

2023

Volume 4, Issue 1, p1-51

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Case Report Open Access

Neurofibromatosis Type 1 and Crohn’s Disease Association: Case Report

Aamir AlShahrabally, D Coghlan, S Quinn

We described a 15-year-old- a boy who presented with neurofibromatosis type 1 and Crohn’s disease. Neurofibromatosis 1 (NF1) is the most common form of NF, affecting 1 in 3000 individuals. Crohn’s disease is one of the inflammatory bowel diseases. Its incidence is significantly rising in Ireland. Concomitant association of NF1 and Crohn’s disease is a rare finding. This is the first case reported in the paediatric population.

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p1-3 | DOI: 10.33696/Gastroenterology.4.041

Review Article Open Access

Exploring the Use of Point of Care Ultrasound in Screening for Non-Alcoholic Fatty Liver Disease: A Systematic Literature Review and Meta-Analysis

Oscar L. Hernandez, Zoilo Karim Suarez Yeb, Talwinder Nagi, Muhammad Adnan Haider, Charles Vallejo, Fatima Ahson

Non-alcoholic fatty liver disease (NAFLD) is a major cause of cirrhosis and liver failure globally. Despite its broad impact, screening recommendations for NAFLD remain varied based between gastrointestinal societies. Point of care ultrasound (POCUS) has emerged as a new form of screening and diagnosing intrabdominal pathologies including NAFLD. We aimed to estimate the effectiveness of POCUS in screening for NAFLD

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p4-11 | DOI: 10.33696/Gastroenterology.4.042

Clinical Image Open Access

A Rare Endoscopic Finding: Gastric Diverticulum

Yi-Xue Zhou, Qiao-Yun Tong, Wei Liu

A 40-year-old man received upper gastrointestinal endoscopic scan during a health check-up. There was no history suggestive of Helicobacter pylori eradication, reflux esophagitis, peptic ulcer disease and upper abdominal surgery. Endoscopy revealed a wide-mouthed diverticulum of the size of 1.5 × 2 cm between the fundus and greater curvature of the stomach (Figure 1).

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p12-13 | DOI: 10.33696/Gastroenterology.4.043

Review Article Open Access

Preclinical Promise and Clinical Challenges for Innovative Therapies Targeting Liver Fibrogenesis

Tamer A. Addissouky, Majeed M. A. Ali, Ibrahim El Tantawy El Sayed, Yuliang Wang, Ayman El Baz, Naglaa Elarabany, Ahmed A. Khalil

Liver fibrosis resulting from chronic liver injury can progress to cirrhosis and liver failure. Current treatments are limited, creating an urgent need for novel antifibrotic therapies. Multiple emerging approaches have shown preclinical promise in inhibiting liver fibrogenesis or stimulating regeneration, including artificial liver support, stem cell therapy, cell/gene therapy, nanomedicines, immunotherapy, and herbal medicines.

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p14-23 | DOI: 10.33696/Gastroenterology.4.044

Review Article Open Access

Advancements in Drug Delivery Systems for Natural Compounds Targeting Metabolic Disorders Associated with Inflammation

Roberto Sam, Sel Neal

The global incidence of metabolic disorders is on the rise, posing a significant challenge to public health. With remarkable advancements in diagnostic tools and clinical procedures, our understanding of the etiology and underlying pathophysiology of these disorders has expanded considerably. Furthermore, the utilization of in vitro and in vivo experimental models, preceding clinical investigations, has catalyzed numerous breakthroughs in biomedicine, particularly in the identification and development of potential drug candidates for the management of metabolic disorders.

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p24-35 | DOI: 10.33696/Gastroenterology.4.045

Opinion Article Open Access

Blastocystosis and Urticaria: An Overview from a Syndemic Perspective

Luis Fonte Galindo, Yamilé Aleaga Santiesteban, María Ginori Gilke, Yosiel Molina, Yisel Hernández Barrios

Numerous studies have found an association between infection by some species of intestinal parasites and the development of urticarial lesions. In this document we have commented on the published findings that show the association between infection by Blastocystis spp. and urticaria, and on the theorizations in relation to the mechanisms that would explain it.

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p36-42 | DOI: 10.33696/Gastroenterology.4.046

Commentary Open Access

Pediatric Functional Constipation in Clinical Practice: The Continuous Search for the Light at the End of the Tunnel

Nilton Carlos Machado, Juliana Tedesco Dias, Gabriela Nascimento Hercos, Thabata Koester Weber, Mary de Assis Carvalho

Functional constipation (FC) has a pooled world prevalence of 9.5%, a clear definition by Rome IV Criteria, and the NAPGHAN/ESPGHAN guidelines recommendation for management. With well-defined parameters, this commentary discusses the paths followed by the literature to implement different therapeutic modalities over time. The text will prioritize information based on systematic reviews, meta-analyses, or reviews.

Arch Gastroenterol Res, 2023, Volume 4, Issue 1, p43-51 | DOI: 10.33696/Gastroenterology.4.047

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Development of HPV 16/18 E6 Oncoprotein Paperbased Nanokit for Enhanced Detection of HPV 16/18 E6 Oncoprotein in Cervical Cancer Screening

According to global cancer statistics GLOBOCAN, carcinoma of cervix is ranked as the fourth most common malignancy among women worldwide with an estimation of 570,000 cases and 311,000 deaths in 2018. It is the second most common female malignancy in Lowand- Middle Income Countries (LMICs). In Kenya, the prevalence is 25 cases per 100,000 women. Approximately 75% cases of cervical cancer are caused by persistent infections of the cervical mucosal epithelium with carcinogenic types of human papillomaviruses (HPVs) mainly 16 and 18.

Is Citrate A Critical Signal in Immunity and Inflammation?

When immune cells are activated, they undergo metabolic change in order to have sufficient energy to function effectively. The Krebs cycle is one of the most important pathways involved in this response and citrate, a critical component of this pathway, regulates carbohydrate and lipid metabolism.

Pain Outcomes with an Elliptical Regimen (POWER) Study: Identifying the Proper Dosage of Exercise for Therapeutic Effect in Persons with Chronic Back Pain

Low back pain (LBP) is one of the most prevalent conditions that will affect 70-85% of individuals at some point in their life [1]. LBP accounts for 2.3% of all visits to the physician, and is the most common area of the body to experience pain [2]. Exercise has been a mainstay for managing persons with chronic low back pain for almost 40

Cardiac Stem Cell Therapy, Quo Vadis

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Dendorbium Nobile Lindl. Alkaloids Suppress NF-κB and NLRP3 Signaling Pathways to Attenuate Lipopolysaccharide-induced Neuroinflammation

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TNFAIP8: Inflammation, Immunity and Human Diseases

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CTLA-4 and PD-L₁ or PD_-1 Pathways: Immune Checkpoint Inhibitors and Cancer Immunotherapy

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Cancer Nanomedicine: Strategies to Enhance Tumor Delivery and Immunotherapy

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Pharmacologic Therapy with Niacin for Nonalcoholic Fatty Liver Disease (NAFLD): Emerging Evidence

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The Role of Anemia in Term and Preterm Pregnancies: Evidence from the Brazilian Multicenter Study on Preterm Birth (EMIP)

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Refractory Gastro-oesophageal Reflux Disease and Laryngopharyngeal Reflux - Use the Bottom up Approach

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Archives of Gastroenterology Research

2023

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