Volume 5, Issue 2, p22-56

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

IL-1 in Abdominal Aortic Aneurysms

Abdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation through immune cell recruitment and activation,

J Cell Immunol, 2023, Volume 5, Issue 2, p22-31 | DOI: 10.33696/immunology.5.163

Is Interstitial Macrophage Mainly Responsible for Lung Injury in SARS-CoV-2 Infection?

The course of the COVID-19 pandemic has led to high mortality rates worldwide, which justifies the development of various research studies aimed at elucidating the physiopathological mechanisms involved in the development of lung injury associated with this disease. The angiotensin-converting enzyme 2 (ACE2) receptor

J Cell Immunol, 2023, Volume 5, Issue 2, p32-35 | DOI: 10.33696/immunology.5.165

Exploring the Potential of Probiotics in Boosting the Immune System's Response to Reduce the Severity of Malaria

Malaria, caused by various strains of malaria parasites such as Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi, is a major threat to human health worldwide. It is estimated that around 3.3 billion people are at risk of developing this disease [1]. Recent research on the human microbiome has revealed a link between resident microbial communities and the risk of blood parasites, offering potential for microbialbased disease treatments such as probiotics [2].

J Cell Immunol, 2023, Volume 5, Issue 2, p36-40 | DOI: 10.33696/immunology.5.166

Sharing Weal and Woe: A Commentary on “Gasdermin E Regulates the Stability and Activation of EGFR in Human Non-Small Cell Lung Cancer Cells”

Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of Non-Small Cell Lung Cancer Cells (NSCLC). Chemoresistance to tyrosine kinase inhibitors (TKIs), which is elicited by EGFR mutations, is a key challenge for NSCLC treatment. In the present study, we demonstrate a critical role of gasdermin E (GSDME), an important protein for pyroptosis, in the maintenance of EGFR stability and activation.

J Cell Immunol, 2023, Volume 5, Issue 2, p41-44 | DOI: 10.33696/immunology.5.167

Dysregulated CXCL12 Expression in Osteoblasts Promotes B-lymphocytes Preferentially Homing to the Bone Marrow in MRL/lpr Mice

Peripheral circulating B-lymphocytes and B-lymphocytes in the bone marrow (BM) show different responses to lymphotoxic or immunosuppressive agents. We explored the existence of a dysregulated distribution of B-lymphocytes between peripheral and BM compartments and the underlying mechanisms. The percentage of CXC chemokine receptor 4+ B (CXCR4+ B) cells was decreased in the peripheral blood (PB) and increased in the BM of MRL/lpr mice and SLE patients.

J Cell Immunol, 2023, Volume 5, Issue 2, p45-56 | DOI: 10.33696/immunology.5.168

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