Journal of Cellular Immunology

2021

Volume 3, Issue 6, p355-418

Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.

Commentary Open Access

Joint Health Markers in Hemophilia: The State of the Art

E.D.P. van Bergen, S.C. Mastbergen, F.P.J.G. Lafeber, R.E.G. Schutgens, L.F.D. van Vulpen

Recurrent joint bleeds in hemophilia lead to (irreversible) joint damage, so-called hemophilic arthropathy causing major morbidity amongst hemophilia patients. Progression of arthropathy is monitored by clinical examination and imaging, but sensitive joint outcome measurements detecting early and subclinical joint damage are lacking. Biochemical markers reflecting joint tissue turnover can potentially provide this significant information about the joint status.

J Cell Immunol, 2021, Volume 3, Issue 6, p355-363 | DOI: 10.33696/immunology.3.124

Review Article Open Access

Megalin-Mediated Trafficking of Mitochondrial Intracrines: Relevance to Signaling and Metabolism

David Sheikh-Hamad, Michael Holliday, Qingtian Li

The multi-ligand binding protein megalin (LRP2) is ubiquitously expressed and facilitates cell uptake of hormones, nutrients and vitamins. We have recently shown megalin is present in the mitochondria of cultured epithelial and mesenchymal cells, as well as many organs and tissues. Mitochondrial megalin associates with stanniocalcin-1 and SIRT3; two proteins that promote anti-oxidant defenses.

J Cell Immunol, 2021, Volume 3, Issue 6, p364-369 | DOI: 10.33696/immunology.3.118

Commentary Open Access

The Return of Tocilizumab for Patients with COVID-19 Pneumonia

Kathy Tin, DO, Annamarie Fernandes, MD, Roderick Go, DO

The COVID-19 pandemic has been devastating for many for over one year. Vaccination has helped decrease the number of cases, but there are still multiple challenges to end the pandemic, such as the advent of variants, vaccine hesitancy, access to vaccines, and the impaired efficacy of vaccines in immunocompromised persons. Due to the hyperinflammatory state of SARS-COV-2 infections, research has been done on treatments that curtail the hyperinflammation.

J Cell Immunol, 2021, Volume 3, Issue 6, p370-374 | DOI: 10.33696/immunology.3.119

Commentary Open Access

Proteome-wide Epitope Prediction: Leveraging Bioinformatic Technologies in Rational Vaccine Design

Lindsay M.W. Piel, Stephen N. White

Artificial intelligence-based prediction technologies have allowed definition of T-cell epitopes presented by Major Histocompatibility Complex (MHC) molecules with allele-specificity of presentation. While some have utilized these technologies on a smaller scale, recent work has expanded the workable proteome size, leveraged both classes of Major Histocompatibility (MHC) molecules, extended the range of host species assessed during comparative analysis, and incorporated pathogen genetic diversity to highlight broadly useful epitopes.

J Cell Immunol, 2021, Volume 3, Issue 6, p375-379 | DOI: 10.33696/immunology.3.120

Commentary Open Access

Application of Mucosal Immune-related Molecular Adjuvants CCL19 and CCL28 in Enhancing the Function of HSV-2 gD DNA Vaccine

Yan Yan, Xu Wang, Renfang Chen

Herpes simplex virus type 2 (HSV-2) develops an annual incidence of 2.3 million people worldwide, which can lead to life-long latent infections, asymptomatic and reactivations, and with occasional symptomatic episodes causing ulcerative lesions in the genitalia and naus. The most serious complications are the long-term neurological sequelae and death of newborns during pregnancy.

J Cell Immunol, 2021, Volume 3, Issue 6, p380-386 | DOI: 10.33696/immunology.3.121

Commentary Open Access

Targeting Ovarian Cancer with IL-2 Cytokine/Antibody Complexes: A Summary and Recent Advances

Yilun Deng, Ryan M Reyes, Chenghao Zhang, José Conejo-Garcia, Tyler J. Curiel

Interleukin (IL)-2 was first identified as a potent T cell growth factor in 1976 and cloned in 1983. In the late 1990s, IL-2 gained further attention as the first immunotherapy demonstrating clinical efficacy against metastatic cancer, as high dose IL-2 was approved by the United States Food & Drug Administration (FDA) for the treatment of metastatic renal cell carcinoma in 1992 and metastatic melanoma in 1998.

J Cell Immunol, 2021, Volume 3, Issue 6, p387-396 | DOI: 10.33696/immunology.3.122

Research Article Open Access

Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease

Tyler C. Hammond, Xin Xing, Lucy M. Yanckello, Arnold Stromberg, Ya-Hsuan Chang, Peter T. Nelson, Ai-Ling Lin

Alzheimer’s disease (AD) is the most common form of dementia with hallmarks of ß-amyloid (Aß) plaques, tau tangles, and neurodegeneration. Studies have shown that neurodegeneration components, especially brain metabolic deficits, are more predictable for AD severity than Aß and tau. However, detailed knowledge of the biochemical composition of AD brain tissue vs. normal brain tissue remains unclear.

J Cell Immunol, 2021, Volume 3, Issue 6, p397-412 | DOI: 10.33696/immunology.3.123

Commentary Open Access

Rethinking Radiation Dose-Fractionation in the Immuno- Oncology Era

Joseph Sia, Nicole M. Haynes

Leveraging the immunomodulatory effects of radiation therapy (RT) for synergy with immunotherapeutic agents for the treatment of cancer is an area of immense interest. A pressing deficiency in the translation of this strategy into the clinic is the lack of clarity on the impact of radiation dose-fractionation on host anti-cancer immune defences.

J Cell Immunol, 2021, Volume 3, Issue 6, p413-418 | DOI: 10.33696/immunology.3.125

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Journal of Cellular Immunology

2021

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