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Journal of Nanotechnology and Nanomaterials
ISSN: 2692-630X
Volume 1, Issue 2, p31-85
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Development of HPV 16/18 E6 Oncoprotein Paperbased Nanokit for Enhanced Detection of HPV 16/18 E6 Oncoprotein in Cervical Cancer Screening
According to global cancer statistics GLOBOCAN, carcinoma of cervix is ranked as the fourth most common malignancy among women worldwide with an estimation of 570,000 cases and 311,000 deaths in 2018. It is the second most common female malignancy in Lowand- Middle Income Countries (LMICs). In Kenya, the prevalence is 25 cases per 100,000 women. Approximately 75% cases of cervical cancer are caused by persistent infections of the cervical mucosal epithelium with carcinogenic types of human papillomaviruses (HPVs) mainly 16 and 18.
J Nanotechnol Nanomaterials, 2020, Volume 1, Issue 2, p31-45 | DOI: 10.33696/Nanotechnol.1.006Engineered Rh Nano-networks on DNA for SERS Applications
The study of surface and interfacial science via analytical techniques is a growing interest in the easy mode of diagnosing probe molecules adsorbed on the surface. In that line, Raman spectroscopy is an analytical method that is inefficient to carry the surface analysis employing their weak cross-sectional scattering until the discovery of Surface-Enhanced Raman Scattering (SERS) in late 1970s
J Nanotechnol Nanomaterials, 2020, Volume 1, Issue 2, p57-64 | DOI: 10.33696/Nanotechnol.1.007Multidirectional Benefits of Nanotechnology in the Diagnosis, Treatment and Prevention of Tuberculosis
Despite the curious advancement in medical science and therapeutics, tuberculosis (TB) persist the primary factor of mortality than any other infectious disease and socioeconomic disaster for millions of people around the world. According to the World Health Organization (WHO), World’s One-third of the population is infected with this disease and of these, 8 to 10 million people develop active disease and 2 million people die each year and the rest of the infected people remain asymptomatic.
J Nanotechnol Nanomaterials, 2020, Volume 1, Issue 2, p46-56 | DOI: 10.33696/Nanotechnol.1.008Ligand-free Few Atoms Ag Nanoclusters Synthesis and Their Potential Application as Photocatalytic Agents
Reducing the size of a metal from macroscopic to the nanoscale generates a scaling behavior in physical and chemical properties due to the large surface-to-volume fraction. While a further size reduction to small clusters under 2 nm (<~100 atoms) yield geometric and electronic structurwhich are still different from their nanoparticle (NP) counterpart.
J Nanotechnol Nanomaterials, 2020, Volume 1, Issue 2, p65-71 | DOI: 10.33696/Nanotechnol.1.009Developing Neo-bioplastics for the Realization of Carbon Sustainable Society
Plastic is a composite material made from organic polymers and can be freely molded into a film, fiber, or plate by heat or pressure processing. In 1839, Goodyear proposed the vulcanization of natural rubbers, while E. Simon discovered polystyrene
J Nanotechnol Nanomaterials, 2020, Volume 1, Issue 2, p72-85 | DOI: 10.33696/Nanotechnol.1.010DNA Nanotechnology Engineered Vesicle for Mimicking Biomolecular Signaling
Bio-inspired strategy is kind of interesting to fabricate devices and perform dynamic operations [1]. Various devices have been made, such as airplane, radar and submarine. In life science, as the fundamental entity, million years’ evolution enables cell becomes the most successful functionality.
Exploiting Nanotechnology to Target Viruses
Infectious diseases caused by microorganisms of the most varied natures and by viral entities cause millions of deaths every year. Around the world, viral infections have impacted civilizations’ circumstances since the earliest times, including the current panorama of the SARS-CoV-2 pandemic known as coronavirus disease in 2019 (COVID-19). In this sense, in the last century,
Bioconjugation of AuNPs with HPV 16/18 E6 Antibody through Physical Adsorption Technique
HPV 16/18 E6 oncoprotein has been evaluated as a useful biomarker with prognostic abilities as it can detect pre-cancer and cancerous states of cervical cancer progression. A positive E6 assay indicates a high correlation to the cervical cancerous phenotype, not the potential for cervical cancer, thus high specificity in triaging patients during screening. E6 levels of expression associate directly with the severity of cervical intraepithelial neoplasia (CIN) lesions and the risk of
Development of HPV 16/18 E6 Oncoprotein Paperbased Nanokit for Enhanced Detection of HPV 16/18 E6 Oncoprotein in Cervical Cancer Screening
According to global cancer statistics GLOBOCAN, carcinoma of cervix is ranked as the fourth most common malignancy among women worldwide with an estimation of 570,000 cases and 311,000 deaths in 2018. It is the second most common female malignancy in Lowand- Middle Income Countries (LMICs). In Kenya, the prevalence is 25 cases per 100,000 women. Approximately 75% cases of cervical cancer are caused by persistent infections of the cervical mucosal epithelium with carcinogenic types of human papillomaviruses (HPVs) mainly 16 and 18.
In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach
SARS-CoV-2 belongs to the genus Beta of the Coronaviridae family of enveloped single-stranded, positive-sense ribonucleic acid (RNA) with a genome length of 30,000bp. The virion is composed of various non-structural (RNA dependent RNA polymerase also known as RdRp) and structural proteins such as Spike (S), Nucleocapsid (N), Matrix (M), and Envelope (E) proteins.
Admitting UnKnown Biosimilar- Drugs Affects Thrombosis and Haemostasis Processes
Accidental admitting and using (un-) known drugs might manipulate health and/or disease(s) of a subject in a positive (healing) and/or negative way (increased mortality and morbidity rate).
Multidirectional Benefits of Nanotechnology in the Diagnosis, Treatment and Prevention of Tuberculosis
Despite the curious advancement in medical science and therapeutics, tuberculosis (TB) persist the primary factor of mortality than any other infectious disease and socioeconomic disaster for millions of people around the world. According to the World Health Organization (WHO), World’s One-third of the population is infected with this disease and of these, 8 to 10 million people develop active disease and 2 million people die each year and the rest of the infected people remain asymptomatic.
Ligand-free Few Atoms Ag Nanoclusters Synthesis and Their Potential Application as Photocatalytic Agents
Reducing the size of a metal from macroscopic to the nanoscale generates a scaling behavior in physical and chemical properties due to the large surface-to-volume fraction. While a further size reduction to small clusters under 2 nm (<~100 atoms) yield geometric and electronic structurwhich are still different from their nanoparticle (NP) counterpart.
Developing Neo-bioplastics for the Realization of Carbon Sustainable Society
Plastic is a composite material made from organic polymers and can be freely molded into a film, fiber, or plate by heat or pressure processing. In 1839, Goodyear proposed the vulcanization of natural rubbers, while E. Simon discovered polystyrene
Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery in Stage 1B2 Cervical Cancer
In 2020 we published a series of 18 patients who underwent neoadjuvant chemotherapy (NACT) and vaginal radical trachelectomy (VRT) as a fertility sparing alternative in stage 1B2 cervical cancer.
Green Nanotechnology: The Influence of Intermolecular and Supramolecular Interactions
In the last decade, the study of nanometer-scale particles has grown exponentially worldwide. This growth is due to the broad field of nanostructures applications, which, due to their dimensions in nanometric sizes, have new properties not found in micro and macro scale. These properties result from the increase in the ratio between the surface area and volume, and the nanostructures’ size directly influences these. Tolerance to temperature, variety of colors, changes in chemical reactivity,
Drugs and Family Medicine: Form and Content
Choosing an individual medication for a particular patient is one of the most important clinical decisions in family medicine (FM). Prescription of drugs is currently the main tool of FM and that’s the main source of prescription of drugs.
Purinergic System and Cervical Cancer: Perspectives
We have recently published an article entitled “Purinergic signaling and tumor microenvironment in cervical Cancer”. In this paper, we reviewed the last studies about purinergic signaling and cervical cancer, highlighting the intrinsic factors related to the inflammatory process, such as extracellular nucleotides and adenosine - components of the purinergic system.
Nanotechnology in Water Treatment: An Optimistic Perspective for the Near Future
Unequal access to drinking water and basic sanitation are old issues in Brazil and worldwide. Besides, this situation foments the proliferation of infectious parasitic diseases. Moreover, mainly in underdeveloped countries, it victimizes socioeconomically vulnerable people. The degree of water contamination analysis, usually by fecal matter, is made by the number of microorganisms present in the sample, including Escherichia coli or thermotolerant coliforms. In addition, several
Folic acid-chitosan Nanomaterials for delivery of dietary polyphenols
Despite the health benefits associated with polyphenols, the bioavailability of many polyphenols limits their effects. Problems with poor solubility fast-metabolism and food preparation techniques limit the bioavailability and bioactivity of these dietary micronutrients. Encapsulation of polyphenols has shown to protect and increase bioavailability of these dietary compounds and to enhance their anticancer activity.
Using Intralipid to Improve Delivery of Anti-Cancer Nanodrugs: Effects on RES Clearance and Toxi city, EPR, and Immune Modulation
Encapsulation of therapeutic molecules (e.g., small molecule inhibitors, mRNA, siRNA, aptamers, etc.) into nanomaterials can improve the solubility and blood circulation of the drugs, alter their biodistribution, decrease their toxicities, overcome drug resistance, and facilitate their entry into target cells. The development of anti-cancer nanodrugs has been the focus of intense study for decades. Several anti-cancer nanodrugs have been approved for clinical use all over the world.
Nanotechnology for Water Purification – Current Trends and Challenges
Environmental pollution is a significant concern in both developing and developed countries. The pollution load in the environment accumulates as a result of anthropogenic activity. Both organic and inorganic contaminants are hazardous to living things, and their incidence and persistence have risen dramatically in current years.
A Comprehensive Commentary of “Smart Design of High-Performance Surface Enhanced Raman Scattering Substrates”
Recently, our group published a review about surface enhanced Raman scattering (SERS) in SmartMat, which summarized the recent developments of noble metal and semiconductor SERS substrates, and then proposed the key factors for substrate design and future directions.
A Review on Nanotechnology: Applications in Food Industry, Future Opportunities, Challenges and Potential Risks
Nanotechnology is an evolving revolution with enormous promise in a variety of fields, including mechanics, medicine, and the food business. Nanoparticles owing to having greater surface area and enhanced rates of mass transfer seem to pose higher biological and chemical activities, penetrability, catalytic behaviour, enzymatic reactivity, and quantum
Cervical Cancer Prevalence in sub-Saharan Africa and HPV Vaccination Policy: A Public Health Grand Challenge?
“Women are not dying because of diseases we cannot treat. They are dying because societies have yet to make the decision that their lives are worth saving.”
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