Tuberculosis (TB) remains a considerable global health threat and this is the second leading cause of death among all infectious diseases, caused by the bacterium Mycobacterium tuberculosis (Mtb). TB commonly influences the lungs, but it can also affect other parts of the body such as kidney, brain or spine. When drug can no longer kill the TB bacteria, disease is called as drug resistant TB. Besides drug resistant issues long term and multiple drugs regimes are allied with severe side effects such as organ toxicity. Scientific world believe that nanotechnology proposed new ways to address residual scientific concerns for TB. Nanotechnology based ideology have important prospective for diagnosis, treatment and prevention of tuberculosis (TB). Some nanotechnologybased targeting systems offer a promising solution as their nanostructure systems are highly efficient in encapsulating important amount of TB drugs, highly stable, feasible for distinct administration routes such as oral, intravenous and inhalation and could be designed to inhibit systemic clearance and pre-mature degradation. The development of nanoparticle-based aerosol vaccine is undergoing which could provide a great potential in prevention of tuberculosis infection. Considering the role of nanoparticles (NPs) in these three aspects like diagnosis, treatment and prevention of tuberculosis, this article attempts to compile these aspects in hope for better upgrade.
Nanotechnology, Mycobacterium tuberculosis, Drugs, NPs, Granuloma, Isoniazid