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Journal of Experimental Pathology
ISSN: 2694-5061
Volume 2, Issue 4, p151-184
Articles published in this issue are Open Access and licensed under Creative Commons Attribution License (CC BY NC) where the readers can reuse, download, distribute the article in whole or part by mentioning proper credits to the authors.
Repurposing of an Antifungal Drug against Gastrointestinal Stromal Tumors
Molecular docking approaches explore the receptor-ligand conformations within the binding sites of macromolecular targets [1]. Structure-based drug discovery is widely used by the scientific community in Medicinal Chemistry to estimate the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process [2,3].
J Exp Pathol, 2021, Volume 2, Issue 4, p151-163 | DOI: doi.org/10.33696/pathology.2.026Spinal Capillary and Cavernous Haemangiomas in Developmental Age: Our Experience
Vascular anomalies are quite common lesions. They are frequently encountered in the pediatric population, being present at birth or developing later, during infancy, childhood, or adolescence. Most of these lesions are benign. Nevertheless, even benign lesions may exhibit significant morbidity without idoneous management [1].
J Exp Pathol, 2021, Volume 2, Issue 4, p164-168 | DOI: 10.33696/pathology.2.027Varying Presentations of EBV-associated Clinical Entities with Emphasis on EBV-Associated T- and NK-cell Lymphoproliferative Disorders of Childhood
The Epstein-Barr Virus (EBV) is an endemic human herpesvirus, with 90% of people demonstrating serological evidence of prior exposure to EBV. In most cases, primary infections of EBV generate mild or asymptomatic clinical courses, but may present as infectious mononucleosis if contracted during young adulthood. In a small percentage of cases, Epstein- Barr virus infection may manifest as a noncanonical reaction, yielding a wide variety of clinical manifestations.
J Exp Pathol, 2021, Volume 2, Issue 4, p169-173 | DOI: 10.33696/pathology.2.028Neuroprotective Effects of Khaya Anthotheca (Welw.) C.DC (Meliaceae) Decoction on Neurodegeneration Induced by Estrogen Depletion in Rats
The cortex, hippocampus, and amygdala are among the brain regions where estrogens may act to improve cognition, memory and mood. In these regions, estrogens have many beneficial effects, including neuroprotection, neurogenesis, as well as neurotrophic, antioxidant, and anti-inflammatory effects [1-2].
J Exp Pathol, 2021, Volume 2, Issue 4, p174-181 | DOI: 10.33696/pathology.2.029Colonoscopy Audit Increases Detection of Sessile Serrated Polyps
Detection and removal of all adenomas at colonoscopy is associated with a reduced interval cancer rate [1,2]. This is consistent with the adenoma-carcinoma sequence for colorectal cancer. The identification of the serrated polyp cancer pathway has emphasized the importance of detection and removal of sessile serrated polyps. Serrated polyps are precursor lesions accounting for 15% to 30% of colorectal cancers. They are overrepresented as a cause of interval cancers [3].
J Exp Pathol, 2021, Volume 2, Issue 4, p182-184 | DOI: 10.33696/pathology.2.030Searching for Easy Reliable Prognostic Parametres in Colorectal Cancer Patients Evaluation
Despite the advances in diagnostic and therapeutic field, colorectal cancer (CRC) still remains the third most common cause of death worldwide, with more than 600,000 cancer-related deaths per year.
Safety and Efficacy of s-MOX Regimen in Patients with Colorectal Cancer Who Developed Cardiotoxicity Following Fluoropyrimidine Administration: A Case Series
5-fluorouracil (5-FU), an antimetabolite in the fluoropyrimidine class, is the third most commonly used chemotherapeutic agent worldwide for the treatment of solid malignancies [1]. Despite advances in novel cancer therapies, commonly used in combination with fluoropyrimidines, 5-FU remains one of the most effective and safe chemotherapy agents to manage colorectal cancer (CRC).
In silico Analysis for the Repurposing of Broad-spectrum Antiviral Drugs against Multiple Targets from SARS-CoV-2: A Molecular Docking and ADMET Approach
SARS-CoV-2 belongs to the genus Beta of the Coronaviridae family of enveloped single-stranded, positive-sense ribonucleic acid (RNA) with a genome length of 30,000bp. The virion is composed of various non-structural (RNA dependent RNA polymerase also known as RdRp) and structural proteins such as Spike (S), Nucleocapsid (N), Matrix (M), and Envelope (E) proteins.
No Studies in Stroke Regarding Brain fMRI Activity and Pelvic Floor Muscle Training/Activation - Only Studies in Non-stroke Population: A Review of Neuroimaging Studies
Neurogenic lower urinary tract dysfunction (NLUTD) is highly prevalent in poststroke patients, leading to major impact on the quality of life (QoL) and healthcare resources. Pelvic floor muscle training (PFMT) has, over the past two decades, been recommended as first-line treatment for neurologically healthy patients with lower urinary tract symptoms (LUTS).
Folic acid-chitosan Nanomaterials for delivery of dietary polyphenols
Despite the health benefits associated with polyphenols, the bioavailability of many polyphenols limits their effects. Problems with poor solubility fast-metabolism and food preparation techniques limit the bioavailability and bioactivity of these dietary micronutrients. Encapsulation of polyphenols has shown to protect and increase bioavailability of these dietary compounds and to enhance their anticancer activity.
Immunological Features with DNA Microsatellite Alterations in Patients with Colorectal Cancer
DNA microsatellites are tandemly repeating short (1-6 base pairs) DNA motifs, such as mononucleotide (A)n, dinucleotide (CA)n, trinucleotide (CAG)n, and tetranucleotide (AAAG)n, with each motif potentially repeating up to 50 times.
Autism – A Potential Autoimmune Disease Neurodegeneration-Induced Autoantibodies against Neural Proteins
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulty in communication and repetitive behaviors [1]. ASD definition includes: atypical autism, high-functioning autism, and Asperger’s disorder. Individuals with ASD may have extraordinarily high IQ, normal intellectual abilities, or intellectual disability (ID), known as ASD with ID.
Emerging Strategies to Attack Polyploid Cancer Cells
While cells with a 2n complement of chromosomes are defined as diploid, cells that possess greater than 2n are referred to as polyploid.
Endoscopic Ultrasound-Guided Liver Biopsy; the Pathologist’s Perspective
In this study, the safety and efficacy of liver biopsies performed by endoscopic ultrasound (EUS-LB) were compared with those performed via the traditional percutaneous route at our Medical Center between January 2018 and August 2019.
Gastric GIST with 13 kg in Asymptomatic Patient: A Rare Case of Giant GIST and Literature Review
Although gastrointestinal stromal tumors, GISTs, are the most common neoplasms arising from the gastrointestinal mesenchyme, they represent less than 1% of all digestive tumors. Its incidence has increased in recent years, probably due to improved diagnostic methods. It is currently known that GIST is the most common sarcoma. It originates from interstitial cells of Cajal and depends on the transcription factor ETV-1. These are neoplasms associated with molecular alterations and some mutations.
New Trends in Interrelation of Infectious Colorectal Cancer with Intestinal Microbiota
The intestinal microbiota creates a bodily barrier for invading pathogen by using aggressive exclusion. Pathogens and immune cells can interact directly and dynamically with symbiotic bacteria, determining the pathophysiology and outcome of an infection. They can defend the host through a variety of processes, including attachment site occupancy, nutrition intake, metabolite competition, and the synthesis of antimicrobial compounds including bacteriocins that influence pathogen survival (a process referred to as colonization resistance).
Antifungal Effects of PC945, a Novel Inhaled Triazole, on Candida albicans Pulmonary Infection in Immunocompromised Mice
Candida spp. are often detected from fungal cultures or mycobiome analysis of respiratory secretions, but are not usually treated since, even if detected persistently, the presence is assumed to be benign colonization unless invasive candidiasis in deeply immunocompromised subjects is suspected.
Breast Implant-associated Anaplastic Large Cell Lymphoma: A Review with Emphasis on the Role of Brentuximab Vedotin
Anaplastic large cell lymphoma (ALCL) represents a heterogeneous group of T-cell lymphomas, which characteristically express CD30 and are associated with translocations involving the anaplastic lymphoma kinase (ALK) gene on chromosome 2p23 [1]. Systemic ALCL, which may be subclassified by the presence or absence of
Hamstrings Injuries with MRI Findings in a Major League Soccer Team
Hamstring injuries are the most common pathology reported in professional soccer players and represent about 10-30% of all injuries. The hamstring complex is comprised of three muscles located in the posterior compartment of the thigh including the semimembranosus (SM), semitendinosus (ST), and biceps femoris (BF), which is comprised of the long head (BFLH) and short head (BFSH).
Repurposing of an Antifungal Drug against Gastrointestinal Stromal Tumors
Molecular docking approaches explore the receptor-ligand conformations within the binding sites of macromolecular targets [1]. Structure-based drug discovery is widely used by the scientific community in Medicinal Chemistry to estimate the ligand-receptor binding free energy by evaluating critical phenomena involved in the intermolecular recognition process [2,3].
Spinal Capillary and Cavernous Haemangiomas in Developmental Age: Our Experience
Vascular anomalies are quite common lesions. They are frequently encountered in the pediatric population, being present at birth or developing later, during infancy, childhood, or adolescence. Most of these lesions are benign. Nevertheless, even benign lesions may exhibit significant morbidity without idoneous management [1].
Varying Presentations of EBV-associated Clinical Entities with Emphasis on EBV-Associated T- and NK-cell Lymphoproliferative Disorders of Childhood
The Epstein-Barr Virus (EBV) is an endemic human herpesvirus, with 90% of people demonstrating serological evidence of prior exposure to EBV. In most cases, primary infections of EBV generate mild or asymptomatic clinical courses, but may present as infectious mononucleosis if contracted during young adulthood. In a small percentage of cases, Epstein- Barr virus infection may manifest as a noncanonical reaction, yielding a wide variety of clinical manifestations.
Neuroprotective Effects of Khaya Anthotheca (Welw.) C.DC (Meliaceae) Decoction on Neurodegeneration Induced by Estrogen Depletion in Rats
The cortex, hippocampus, and amygdala are among the brain regions where estrogens may act to improve cognition, memory and mood. In these regions, estrogens have many beneficial effects, including neuroprotection, neurogenesis, as well as neurotrophic, antioxidant, and anti-inflammatory effects [1-2].
Colonoscopy Audit Increases Detection of Sessile Serrated Polyps
Detection and removal of all adenomas at colonoscopy is associated with a reduced interval cancer rate [1,2]. This is consistent with the adenoma-carcinoma sequence for colorectal cancer. The identification of the serrated polyp cancer pathway has emphasized the importance of detection and removal of sessile serrated polyps. Serrated polyps are precursor lesions accounting for 15% to 30% of colorectal cancers. They are overrepresented as a cause of interval cancers [3].
Molecular Tools for Metastatic Colorectal Cancer Characterization
The American Cancer Society estimates there will be 156,540 new diagnoses and 53,200 deaths from colorectal cancer (CRC) in the United States in 2020.
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