Research Article Open Access
Volume 2 | Issue 4 | DOI: https://doi.org/10.33696/pathology.2.029

Neuroprotective Effects of Khaya Anthotheca (Welw.) C.DC (Meliaceae) Decoction on Neurodegeneration Induced by Estrogen Depletion in Rats

  • 1Department of health, Private Bilingual Higher Institute les Armandins, University of Ngaoundere, P.O. Box 7045, Yaounde,Cameroon
  • 2Department of Psychology, Faculty of Arts, Letters and Social Science, University of Yaounde I, P.O. Box 7011, Yaounde, Cameroon
  • 3Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
  • 4Center for Sustainable Health and Development, and Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Ngaoundéré, P.O. Box 317, Garoua, Cameroon
  • 5Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O.Box 1364, Yaounde, Cameroon
  • 6Department of Medical Laboratories, Faculty of Basic Health Sciences, Qassim University, 41452, Buraydah, Saudi Arabia
+ Affiliations - Affiliations

Corresponding Author

ZEMO GAMO Franklin, zemogamofranklin@yahoo.fr

Received Date: October 08, 2021

Accepted Date: December 10, 2021


Background: Recently, we reported estrogen-like and anxiolytic effects of the decoction of Khaya anthotheca in ovariectomized rats. Rationale: The purpose of the present study was to assess the putative neuroprotective properties of the plant in ovariectomized rats. Methods: Thirty female Wistar rats were ovariectomized, while 6 were used as sham. After 14 days of endogenous hormonal decline, animals were randomly divided into six groups (n=6) and administered with distilled water, K. anthotheca decoction (125, 250 and 500 mg/kg doses) or estradiol valerate (1 mg/kg) for 28 days. Phytochemical analysis and antioxidant potential of the decoction were determined. Levels of oxidative stress biomarkers were determined in brain homogenates, while histopathological analysis was performed on brain sections, and expressions of neuroinflammation markers determined. Results: Polyphenols were detected in K. anthotheca, and the ferric reducing antioxidant power (FRAP) assay revealed antioxidant properties (635.50 ± 0.58 mg eq quercetin/g of dried decoction). Treatment with K. anthotheca decoction reduced MDA and increased GSH levels in brain homogenates (p<0.01). As estradiol valerate, the decoction, prevented neurodegeneration observed in cortices and hippocampi of untreated ovariectomized animals. Conclusions: Our results suggested that K. anthotheca is endowed with neuroprotective effects and warrant further studies, including other models of neurodegeneration and dementia.


Khaya anthotheca, neuroprotection, antioxidative effects, ovariectomy, estrogen depletion, neurodegeneration, oxidative stress.

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